公开(公告)号：AR122351A1

公开(公告)日：2022-09-07

申请号：ARP200103417

申请日：2020-12-09

Applicant: HOFFMANN LA ROCHE

Inventor： DOLENTE COSIMO ,  HEWINGS DAVID ,  HUNZIKER DANIEL ,  KRUMMENACHER DANIELA ,  PETTAZZONI PIERGIORGIO ,  WICHMANN JUERGEN

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00

Abstract: Se proveen compuestos derivados de 3-metil-4-oxo-quinazolina que poseen actividad inhibidora de BRAF, un proceso para su preparación, una composición farmacéutica que comprende a uno de éstos compuestos y el uso de los mismos para el tratamiento de diversos tipos de cáncer. Reivindicación 1: El compuesto de la fórmula (1) o una sal aceptable desde el punto de vista farmacéutico de este.

公开(公告)号：MX2022006783A

公开(公告)日：2022-07-11

申请号：MX2022006783

申请日：2020-12-08

Applicant: HOFFMANN LA ROCHE

Inventor： HUNZIKER DANIEL ,  WICHMANN JUERGEN ,  DOLENTE COSIMO ,  HEWINGS DAVID STEPHEN ,  KRUMMENACHER DANIELA ,  PETTAZZONI PIERGIORGIO FRANCESCO TOMMASO

IPC: A61P35/00 ,  A61K31/517 ,  C07D403/12

Abstract: La invención proporciona un compuesto novedoso que tiene la Fórmula general (I) (ver Fórmula) (I), o una sal farmacéuticamente aceptable de este. El compuesto de Fórmula (I) se puede utilizar como medicamento.

公开(公告)号：AU2020403082A1

公开(公告)日：2022-05-12

申请号：AU2020403082

申请日：2020-12-08

Applicant: HOFFMANN LA ROCHE

Inventor： DOLENTE COSIMO ,  HEWINGS DAVID STEPHEN ,  HUNZIKER DANIEL ,  KRUMMENACHER DANIELA ,  PETTAZZONI PIERGIORGIO FRANCESCO TOMMASO ,  WICHMANN JUERGEN

IPC: C07D239/90 ,  A61K31/517 ,  A61P35/00 ,  C07D403/12

Abstract: The invention provides a novel compound having the general formula (I) (I) wherein R

公开(公告)号：CA2496756C

公开(公告)日：2012-01-10

申请号：CA2496756

申请日：2003-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： IDING HANS ,  JOLIDON SYNESE ,  KRUMMENACHER DANIELA ,  RODRIGUEZ SARMIENTO ROSA MARIA ,  THOMAS ANDREW WILLIAM ,  WIRZ BEAT ,  WOSTL WOLFGANG ,  WYLER RENE

IPC: C07D207/26 ,  A61K31/4015 ,  A61P25/16 ,  A61P25/28 ,  C07D207/273 ,  C07D207/277 ,  C07D401/04

Abstract: Racemic enantiomerically pure 4- pyrrolidino derivatives of formula (I), processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer~s disease or senile dementia.

公开(公告)号：DE60331559D1

公开(公告)日：2010-04-15

申请号：DE60331559

申请日：2003-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： IDING HANS ,  JOLIDON SYNESE ,  KRUMMENACHER DANIELA ,  RODRIGUEZ SARMIENTO ROSA MARIA ,  THOMAS ANDREW WILLIAM ,  WIRZ BEAT ,  WOSTL WOLFGANG ,  WYLER RENE

IPC: C07D207/26 ,  A61K31/4015 ,  A61P25/16 ,  A61P25/28 ,  C07D207/273 ,  C07D207/277 ,  C07D401/04

Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.

公开(公告)号：AU2003267381B2

公开(公告)日：2009-08-27

申请号：AU2003267381

申请日：2003-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： WIRZ BEAT ,  JOLIDON SYNESE ,  SARMIENTO ROSA MARIA RODRIGUEZ ,  KRUMMENACHER DANIELA ,  WYLER RENE ,  IDING HANS ,  WOSTL WOLFGANG ,  THOMAS ANDREW WILLIAM

IPC: C07D207/273 ,  A61K31/4015 ,  A61P25/16 ,  A61P25/28 ,  C07D207/26 ,  C07D207/277 ,  C07D401/04

Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.

公开(公告)号：MY133332A

公开(公告)日：2007-11-30

申请号：MYPI20033558

申请日：2003-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： IDING HANS ,  JOLIDON SYNESE ,  KRUMMENACHER DANIELA ,  SARMIENTO ROSA MARIA RODRIGUEZ ,  THOMAS ANDREW WILLIAM ,  WIRZ BEAT ,  WOSTL WOLFGANG ,  WYLER RENE

IPC: A61K31/40 ,  C07D207/26 ,  A61K31/4015 ,  A61K31/44 ,  A61P25/16 ,  A61P25/28 ,  C07D207/273 ,  C07D207/277 ,  C07D401/04 ,  C07D401/06

Abstract: RACEMIC OR ENANTIOMERICALLY PURE 4-PYRROLIDINO DERIVATIVES, PROCESSES FOR THEIR PEREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES, AND THEIR USE IN THE PREVENTION AND TREATMENT OF A DISEASE WHICH IS MEDIATED BY A MONOAMINE OXIDASE B INHIBITOR, IN PARTICULAR ALZHEIMER'S DISEASE AND SENILE DEMENTIA.

公开(公告)号：MXPA06002944A

公开(公告)日：2006-05-31

申请号：MXPA06002944

申请日：2004-09-15

Applicant: HOFFMANN LA ROCHE

Inventor： KRUMMENACHER DANIELA

IPC: C07D207/277 ,  C12P17/10 ,  C12P41/00 ,  C07D207/26 ,  C12R1/72

Abstract: La presente invencion se refiere a un proceso para la preparacion de intermediarios enantiopuros utiles en la sintesis de compuestos activos farmaceuticamente, valiosos, por ejemplo inhibidores de MAOB, y a compuestos intermedios novedosos de las formulas (I) y (II) en donde R21, R22, R23 y R24 son como se definieron en la descripcion y reivindicaciones.

公开(公告)号：BR0314299A

公开(公告)日：2005-12-13

申请号：BR0314299

申请日：2003-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： IDING HANS ,  KRUMMENACHER DANIELA ,  SARMIENTO ROSA MARIA RODRIGUEZ ,  THOMAS ANDREW WILLIAM ,  WIRZ BEAT ,  WOSTL WOLFGANG ,  WYLER RENE ,  JOLIDON SYNESE

IPC: A61K31/4015 ,  A61P25/16 ,  A61P25/28 ,  C07D207/26 ,  C07D207/273 ,  C07D207/277 ,  C07D401/04

Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.

公开(公告)号：ZA202204092B

公开(公告)日：2022-12-21

申请号：ZA202204092

申请日：2022-04-11

Applicant: HOFFMANN LA ROCHE

Inventor： DOLENTE COSIMO ,  HEWINGS DAVID STEPHEN ,  HUNZIKER DANIEL ,  KRUMMENACHER DANIELA ,  PETTAZZONI PIERGIORGIO FRANCESCO TOMMASO ,  WICHMANN JUERGEN

Abstract: The invention provides a novel compound having the general formula (I)wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.