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    PROCESS PREPARING FOR PYROLIDINE DERIVATIVES
    1.
    发明授权
    PROCESS PREPARING FOR PYROLIDINE DERIVATIVES 失效

    公开(公告)号：KR800001279B1

    公开(公告)日：1980-10-26

    申请号：KR760000422

    申请日：1976-02-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  SCHNEIDER F ,  PFOERTNER K

    IPC: C07D207/10

    Abstract: Analgesic pyrrolidine derivs. (I; R1 = pyridy1; R2 = H, lower alky1; R3 = H, lower alky1, benzy1; R4 = halogen, lower alcohol, lower alkoxy, nitro, and amino-substituted pheny1) were prepd. by the redn. of pyrrolines II. Thus, 4-methy1-4-nitro-3-(4-pytidy1)-valerophenon was reduced by Zn in CH3COOH followed by treating with 1n-HC1 and crystallizing with EtOH/(CH3)2CO gave trans-4-(2,2-dimethy1-5-pheny1-pyrolidy1)-pyridine dihydrochloride. I are useful as non-addictive analgesic agent, 3.0g., racemic 4-(cis-2,2-dimethy1-5-pheny1-3-pyrrolidiny1)-pyridine dihydrochloride had ED50 47mg/kg.

    5.
    发明专利
    未知

    公开(公告)号：BR7601094A

    公开(公告)日：1976-09-14

    申请号：BR7601094

    申请日：1976-02-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  SCHMID H ,  PFOERTNER K ,  SCHNEIDER F

    IPC: C07D213/50 ,  C07D401/04

    Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

    6.
    发明专利
    未知

    公开(公告)号：SE7602069L

    公开(公告)日：1976-08-23

    申请号：SE7602069

    申请日：1976-02-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F ,  SCHMID H

    IPC: C07D213/50 ,  C07D401/04

    Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

    9.
    发明专利
    未知

    公开(公告)号：DK545980A

    公开(公告)日：1981-06-22

    申请号：DK545980

    申请日：1980-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  PFOERTNER K

    IPC: C07D263/10 ,  C07D

    Abstract: Compounds of the formula I wherein R1 and R2, independently, are hydrogen, halogen or lower alkyl; R3, R4, R5, R6 and R7, independently, are hydrogen or lower alkyl; R8 is hydrogen, lower alkyl or formyl; R9 and R10, independently, are methyl or trifluoromethyl; and n is 0 (zero) or, when both R7 and R8 are lower alkyl, n is 0 (zero) or 1, prepared, inter alia, from p-aminobenzaldehydes which may be N-alkyl substituted, are described. The compounds of formula I are orally active antidiabetic agents.

    PYRROLIDINE DERIVATIVES
    10.
    发明专利
    PYRROLIDINE DERIVATIVES 未知

    公开(公告)号：AU500184B2

    公开(公告)日：1979-05-10

    申请号：AU1062976

    申请日：1976-01-29

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F ,  SCHMID H

    IPC: C07D213/50 ,  C07D401/04 ,  A61K31/44

    Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

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