中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

70 records (took 0.022 seconds)

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    1.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002386B1

    公开(公告)日：1982-12-29

    申请号：KR780003228

    申请日：1978-10-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/72

    Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances. Thus, 3, 4-(F3C)ClC6H3NCO reacted with Me2CHCH(NH2)CN at 100≦̸ to give I(R=CF5, R1=Cl, R2=H, z= NH), which washydrolyzed to I(Z=O).

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    2.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002387B1

    公开(公告)日：1982-12-29

    申请号：KR820004633

    申请日：1982-10-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/72

    Abstract: Title compds. (I; R=II, III, IV, V, VI), useful as an schistosomicide and antiandrogenic substance were prepd. by hydrolyzing Ia. Thus, 61 mg 1-(3-trifluoromethy1-4-chloro-pheny1)-5-imino-4, 4-dimethy1-2-imidazolidinone was dissolved in 4 ml 0.1N HCl, added 2ml H2O and filtrated after 20 hr to give 3-(3-trifluoromethy1-4-chloropheny1)-5,5-dimethylhydantoin(m.p. 156-157.5oC).

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    4.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002388B1

    公开(公告)日：1982-12-29

    申请号：KR820004632

    申请日：1982-10-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/90

    Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances (test data tabulated). Thus, 3,4-(F3C)CLC6H3NCO reacted with Me2CH(NH2)CN at 100≦̸C to give I(R = CF5, R1 = Cl, R2 = H, Z = NH), which was hydrolyzed to give I(Z = O)

    PROCESS PREPARING FOR PYROLIDINE DERIVATIVES
    5.
    发明授权
    PROCESS PREPARING FOR PYROLIDINE DERIVATIVES 失效

    公开(公告)号：KR800001279B1

    公开(公告)日：1980-10-26

    申请号：KR760000422

    申请日：1976-02-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  SCHNEIDER F ,  PFOERTNER K

    IPC: C07D207/10

    Abstract: Analgesic pyrrolidine derivs. (I; R1 = pyridy1; R2 = H, lower alky1; R3 = H, lower alky1, benzy1; R4 = halogen, lower alcohol, lower alkoxy, nitro, and amino-substituted pheny1) were prepd. by the redn. of pyrrolines II. Thus, 4-methy1-4-nitro-3-(4-pytidy1)-valerophenon was reduced by Zn in CH3COOH followed by treating with 1n-HC1 and crystallizing with EtOH/(CH3)2CO gave trans-4-(2,2-dimethy1-5-pheny1-pyrolidy1)-pyridine dihydrochloride. I are useful as non-addictive analgesic agent, 3.0g., racemic 4-(cis-2,2-dimethy1-5-pheny1-3-pyrrolidiny1)-pyridine dihydrochloride had ED50 47mg/kg.

    PRCESS FOR PYROLIDINES
    6.
    发明授权
    PRCESS FOR PYROLIDINES 失效

    公开(公告)号：KR800001143B1

    公开(公告)日：1980-10-14

    申请号：KR770001711

    申请日：1977-07-25

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  SCHNEIDER F ,  WERTNER K ,  SCHMITT H

    IPC: C07D207/09

    Abstract: Title compds. (I; R1 = 2-thienyl or phenyl substuted with lower t-amino group, R2 and R3 are independently, H or lower alkyl; R4 = halogen, lower alkyl, lower alkoxy, nitro, phenyl), useful as anaesthetics, were prepd. by reduction of compd. II in the presence of catalyst. Thus, 17 g 2-(P-methoxy-phenyl)-5, 5-dimethyl-4-(2-thienyl)-1-pyrroline and 10 g sodium borohydride were reacted in 250 ml anhydrous ethanol gor 6 hr with N2 gas to give cis-5-(p-methoxyphenyl)-2, 2-dimethyl-3-(2-thienyl)-pyrrolidine hydrochloric acid salt (m.p. 180oC).

    8.
    发明专利
    未知

    公开(公告)号：MC1366A1

    公开(公告)日：1981-10-23

    申请号：MC1490

    申请日：1980-12-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： PFOERTNER K ,  BERNAUER K

    IPC: C07D263/10 ,  C07D ,  A61K

    Abstract: Compounds of the formula I wherein R1 and R2, independently, are hydrogen, halogen or lower alkyl; R3, R4, R5, R6 and R7, independently, are hydrogen or lower alkyl; R8 is hydrogen, lower alkyl or formyl; R9 and R10, independently, are methyl or trifluoromethyl; and n is 0 (zero) or, when both R7 and R8 are lower alkyl, n is 0 (zero) or 1, prepared, inter alia, from p-aminobenzaldehydes which may be N-alkyl substituted, are described. The compounds of formula I are orally active antidiabetic agents.

    NOVEL OXAZOLINES
    9.
    发明专利
    NOVEL OXAZOLINES 未知

    公开(公告)号：ZW28780A1

    公开(公告)日：1981-07-15

    申请号：ZW28780

    申请日：1980-11-26

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  PFOERTNER K

    IPC: C07D263/10 ,  A61K ,  C07D

    Abstract: Compounds of the formula I wherein R1 and R2, independently, are hydrogen, halogen or lower alkyl; R3, R4, R5, R6 and R7, independently, are hydrogen or lower alkyl; R8 is hydrogen, lower alkyl or formyl; R9 and R10, independently, are methyl or trifluoromethyl; and n is 0 (zero) or, when both R7 and R8 are lower alkyl, n is 0 (zero) or 1, prepared, inter alia, from p-aminobenzaldehydes which may be N-alkyl substituted, are described. The compounds of formula I are orally active antidiabetic agents.

Patent Agency Ranking