公开(公告)号：JP2007014751A

公开(公告)日：2007-01-25

申请号：JP2006148383

申请日：2006-05-29

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： STAIB ARNULF ,  KLOETZER HANS-MARTIN

IPC: A61B5/145 ,  A61B5/1459 ,  A61M1/36

CPC classification number: A61B5/14532 ,  A61M5/1723 ,  A61M2005/14208 ,  G01N33/66 ,  G01N2800/042

Abstract: PROBLEM TO BE SOLVED: To provide a method for evaluating a series of glucose concentration values of a diabetic in order to adjust the dosing of insulin administrations.
SOLUTION: The method has: a stage where glucose concentration values g(t1) to g(tn) that are related to time points t1 to tn that are distributed over a period of time of at least four hours, preferably at least six hours, are used as input parameters, and based on the concentration values, a disturbance parameter is determined that characterizes the type and/or degree of a disturbance of the tested glucose metabolism that is manifested despite the administration of insulin; and a stage where the disturbance parameter is assigned by means of predetermined parameter ranges to one of at least two predetermined classes, whereby recommendations for adjustment of the dosing of the insulin administrations are assigned to each of the classes as output parameters.
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供用于评估糖尿病患者的一系列葡萄糖浓度值以调节胰岛素给药的剂量的方法。 解决方案：该方法具有：在至少4小时的时间段内分布有与时间点t1至tn相关的葡萄糖浓度值g（t1）至g（tn）的阶段，优选至少 六个小时，作为输入参数，并且基于浓度值，确定干扰参数，其表征尽管施用胰岛素所表现的测试的葡萄糖代谢的类型和/或程度; 以及通过预定参数范围将干扰参数分配到至少两个预定类别中的一个的阶段，由此将用于调整胰岛素给药剂量的建议分配给每个类别作为输出参数。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006255414A

公开(公告)日：2006-09-28

申请号：JP2006064740

申请日：2006-03-09

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： STAIB ARNULF ,  PILL JOHANNES ,  KOTULLA REINHARD ,  HEGGER RAINER

IPC: A61B5/145 ,  A61B10/00

CPC classification number: G01N33/66 ,  A61B5/14532 ,  Y10T436/104998 ,  Y10T436/144444

Abstract: PROBLEM TO BE SOLVED: To provide a method for early detecting glucose cacochymia. SOLUTION: The method comprises a process which measures by allocating to t1 time - tn time over a session of at least 4 hours, preferably at least 6 hours glucose strengths g(t1)-g(tn) in humor, especially blood, a process which calculates the data points of phase space coordinates from glucose strength measured values g(t1)-g(tn), and a process which emphasizes peculiarity related to a disease of the glucose metabolism of an inspected person and/or a disease by processing the data points. Processing of the data points can be carried out by plotting them during phase space expression or determining from the data points a damage factor which has a correlation in the severity of the damage of the glucose metabolism. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种早期检测葡萄糖cacochymia的方法。 解决方案：该方法包括通过在幽默，特别是血液中的至少4小时，优选至少6小时葡萄糖浓度g（t1）-g（tn）的会话中分配t1时间tn时间来测量的过程 ，从葡萄糖强度测量值g（t1）-g（tn）计算相位空间坐标的数据点的过程，以及强调与受检者和/或疾病的葡萄糖代谢疾病相关的特征的过程 通过处理数据点。 数据点的处理可以通过在相位空间表达期间绘制它们或从数据点确定与葡萄糖代谢损伤严重程度相关的损伤因子来进行。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2009031283A

公开(公告)日：2009-02-12

申请号：JP2008187682

申请日：2008-07-18

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： STAIB ARNULF ,  MAYER THOMAS ,  MISCHLER REINHOLD ,  PESCHEL HARALD ,  HAJNSEK MARTIN

IPC: G01N27/327 ,  G01N27/28 ,  G01N27/416

CPC classification number: C12Q1/001 ,  G01N27/3272

Abstract: PROBLEM TO BE SOLVED: To provide a sensor capable of assuring specific and permanent fixing of enzyme and having a high efficiency to accomplish high signal generation, enabling easy and low-cost manufacture.
SOLUTION: The electrochemical sensor to measure an analyte in a fluid medium includes at least one working electrode and at least one reference electrode wherein at least the working electrode contains electrocatalyst particles in an electrode matrix and an enzyme suitable for measurement of the analyte is covalently bonded to the electrocatalyst particles.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供能够确保酶的特异性和永久性固定并且具有高效率以实现高信号生成的传感器，从而能够容易且低成本地制造。 解决方案：用于测量流体介质中的分析物的电化学传感器包括至少一个工作电极和至少一个参比电极，其中至少工作电极在电极基质中含有电催化剂颗粒，适用于测量分析物的酶 共价键合到电催化剂颗粒。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2005131370A

公开(公告)日：2005-05-26

申请号：JP2004262535

申请日：2004-09-09

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： KOTULLA REINHARD ,  STAIB ARNULF

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459

CPC classification number: A61B5/14503 ,  A61B5/14532 ,  A61B5/7207 ,  A61B5/7239 ,  A61B2560/0223

Abstract: PROBLEM TO BE SOLVED: To provide a continuous monitoring method and a continuous monitoring apparatus of a specimen component concentration, comprising a filtering means capable of improving accuracy by removing a noise signal included in a measuring signal.
SOLUTION: A value taken by a measurement variation quantity for indicating a correlation with the concentration being a monitoring object, is measured at a plurality of times juxtaposed in time series, to be set as a measuring signal z
t . An error caused by noise in the measuring signal z
t included in a useful signal y
t by using filtering algorithm of a time area in the useful signal representing a variation in a specific period of the concentration. At this time, a degree of an actually measured measured value contributing to specifying the useful signal y
t is designated to the filtering algorithm by a weight factor V
t . A signal difference parameter σ
t is calculated on the basis of a signal difference related to the measured value acquired in a period in the vicinity of time for performing actual measurement.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种检体成分浓度的连续监视方法和连续监视装置，其包括能够通过去除包含在测量信号中的噪声信号来提高精度的滤波装置。 解决方案：以与时间序列并列的多个时间测量用于指示与作为监测对象的浓度的相关性的测量变化量所获得的值，以被设置为测量信号z < / SB>。 通过使用表示特定的变化的有用信号中的时间区域的滤波算法，包括在有用信号y t 中的测量信号z t 中由噪声引起的误差 集中期。 此时，通过权重因子V SBB，将有助于指定有用信号y t 的实际测量的测量值的程度指定给滤波算法。 基于与在实际测量的时间附近的周期中获取的测量值相关的信号差来计算信号差参数σ t 。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2007130482A

公开(公告)日：2007-05-31

申请号：JP2006305412

申请日：2006-11-10

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： STAIB ARNULF ,  GILLEN RALPH

IPC: A61B5/1473 ,  A61B5/1486

CPC classification number: A61B5/1486

Abstract: PROBLEM TO BE SOLVED: To measure an analyte concentration in a human or animal body by an implantable electrode system precisely. SOLUTION: The implantable electrode system comprises a first and a second measuring electrode for determining measuring signals which each contain information concerning the analyte concentration to be measured, whereby the first measuring electrode has a first measuring sensitivity that is adapted to a first concentration range of the analyte, and the second measuring electrode has a second measuring sensitivity that differs from the first measuring sensitivity and is adapted to a second concentration range of the analyte. Further an apparatus and a method for measuring analyte concentration by means of an electrode system of this type are provided. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：通过精确的可植入电极系统测量人体或动物体内的分析物浓度。 解决方案：可植入电极系统包括用于确定测量信号的第一和第二测量电极，每个测量信号包含关于待测量的分析物浓度的信息，由此第一测量电极具有适于第一浓度的第一测量灵敏度 分析物的范围，第二测量电极具有与第一测量灵敏度不同的第二测量灵敏度，并且适应于分析物的第二浓度范围。 另外提供了一种通过这种电极系统测量分析物浓度的装置和方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006346454A

公开(公告)日：2006-12-28

申请号：JP2006160980

申请日：2006-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： OCVIRK GREGOR ,  RINNE HELMUT ,  STAIB ARNULF

IPC: A61B5/1486 ,  A61B5/1495

Abstract: PROBLEM TO BE SOLVED: To measure the component of a peripheral substrate and the amount of a fluid by a simple method with the use of an implantable apparatus and an appropriate method concerning a sensor system for monitoring the component, particularly, grape sugar in organism tissue, its arrangement, and its method. SOLUTION: The invention concerns the sensor system comprising a support (24) that can be at least partially inserted into body tissue, a fluid channel (28) arranged on the support (24) for conducting a liquid and a sensor (26) that responds to a constituent of the liquid and/or of the body tissue. According to the invention it is proposed that the sensor (26) is arranged on the support (24) separately from the fluid channel (28) for a direct contact with the body tissue. COPYRIGHT: (C)2007,JPO&INPIT

公开(公告)号：JP2005308742A

公开(公告)日：2005-11-04

申请号：JP2005117542

申请日：2005-04-14

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： STAIB ARNULF ,  HEGGER RAINER

IPC: G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  G01N33/48 ,  G06F17/00

CPC classification number: A61B5/14532

Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for monitoring the analyte concentration in a living body such as a human or an animal, wherein analyte values y(t
n ) which can be converted into the analyte concentration to be monitored is observed in a series of time t
n to calculate the analyte concentration.
SOLUTION: In the method for continuously monitoring the analyte component, the formula (4) is determined which depends on the formula (1) and can be used to approximate the progression of analyte values y(t
n ) at time t
n0 in the vicinity U of an analyte value y(t
n0 ), with a predetermined accuracy σ, such that the accuracy σ satisfies the formula (2) and the formula (3) and Δn is an integer. Then, a predictive value is calculated using a function. By determining the progression of the analyte concentration in a living body such as a human or an animal, the analyte value y(t
n ), relevant to the concentration thus obtained, is determined at continuous time T
n . Further, the method is used to predict a predicted value y(t
n0 +Δt) of the analyte value over a prediction period Δt.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种用于监测人体或动物等生物体中的分析物浓度的方法和装置，其中分析物值y（t n ）可以是 在一系列时间t n 中观察到转化成要监测的分析物浓度，以计算分析物浓度。 解决方案：在连续监测分析物成分的方法中，确定取决于式（1）的式（4），并且可以用于近似分析物值y（t n < SB'）在分析物值y（t n0 ）附近的时间t n0 时，具有预定的精度σ，使得精度σ满足公式 2）和公式（3），Δn是整数。 然后，使用函数计算预测值。 通过确定诸如人或动物的活体中的分析物浓度的进展，与所获得的浓度相关的分析物值y（t n ）在连续时间T SB>名词。 此外，该方法用于在预测期间Δt中预测分析物值的预测值y（t n0 +Δt）。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：WO2012092954A3

公开(公告)日：2012-10-18

申请号：PCT/EP2011006500

申请日：2011-12-22

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

CPC classification number: G06F19/70 ,  G09B23/28

Abstract: The invention relates to a method for evaluating a set of measurement data from an oral glucose tolerance test, wherein the set of measurement data contains a sequence of measurement data of the glucose concentration and, in addition, at least one sequence of measured values of a further analyte concentration. Provision is made according to the invention that, from the sequence of measured values of the glucose concentration and from in each case one of several predefined glucose sample profiles, in each case a value of a similarity measure is calculated that quantifies the similarity between the time profile of the sequence of measured values of the glucose concentration and the relevant glucose sample profile, and, from the sequence of measured values of the further analyte concentration and from several predefined analyte sample profiles, in each case a value of a further similarity measure is calculated that quantifies the similarity between the profile of the sequence of measured values of the further analyte concentration and the relevant analyte sample profile, the set of data is characterized, in a vector space having coordinate axes formed from the similarity measures, by a point whose coordinates contain the calculated values of the similarity measures, and the position of this point in relation to reference points that each represent a defined state of health is evaluated, in order to calculate a parameter that indicates the state of the glucose metabolism of the patient.

Abstract translation: 本发明涉及一种方法，用于评估一组口服葡萄糖耐受性测试的测量数据，其中，所述组测量数据包括中的葡萄糖浓度的测量数据的序列，和另一种分析物的测定值的附加的至少一种序列。 根据规定，在每种情况下的相似性度量的值是从葡萄糖浓度的测量值的序列来计算，并且在每种情况下，其量化的葡萄糖浓度和相应的葡萄糖模式历史的测量值的序列的时间进程之间的相似性几个预定葡萄糖样本的演变的一项的发明， 进一步的相似性中的一个值被从其他的分析物浓度的测量值的序列和多个预定的分析物样品的演变的量化其它分析物的浓度和相关的分析物模式历史的测量值的序列的形状之间的相似度计算，在矢量空间中的数据， 具有坐标由相似度措施形成的轴，其特征在于一个点的坐标包含的相似性度量的计算值，这点相对于的位置的基准点，每封 INEN定义健康代表，进行评估，以计算指示患者的葡萄糖代谢的状态的参数。

公开(公告)号：HUE059358T2

公开(公告)日：2022-11-28

申请号：HUE13157968

申请日：2013-03-06

Applicant: HOFFMANN LA ROCHE

Inventor： KOELKER KARL-HEINZ ,  STAIB ARNULF

IPC: C12Q1/00

公开(公告)号：PL2260759T3

公开(公告)日：2015-10-30

申请号：PL10181161

申请日：2005-06-17

Applicant: HOFFMANN LA ROCHE

Inventor： OCVIRK GREGOR ,  RINNE HELMUT ,  STAIB ARNULF

IPC: A61B5/00 ,  A61B5/1486 ,  A61M5/172