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公开(公告)号：BRPI0005616B8
公开(公告)日：2021-07-06
申请号：BRPI0005616
申请日：2000-11-28
Applicant: HOFFMANN LA ROCHE
Inventor： ANDREW SLEIGHT , GUY ANDREW HIGGINS , SONIA MARIA POLI , THERESA MARIA BALLARD , TORSTEN HOFFMANN
IPC: C07D213/74 , C07D413/04 , A61K31/00 , A61K31/4427 , A61K31/5377 , A61P1/06 , A61P1/08 , A61P25/00 , A61P25/22 , A61P25/24 , A61P43/00 , C07D213/00 , C07D213/75 , C07D265/00
Abstract: patente de invenção: "2-(3,5-bis-trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida" . a invenção refere-se ao composto da fórmula o qual é a 2-(3,5-bis-trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida. foi verificado que este composto tem uma alta afinidade pelo receptor para nk-1 e é, portanto, útil no tratamento de doenças que se relacionam a este receptor.
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2.发明专利
公开(公告)号：MX356826B
公开(公告)日：2018-06-15
申请号：MX2016009207
申请日：2011-12-22
Applicant: HOFFMANN LA ROCHE
Inventor： PETER MOHR , DAVID B ROZEMA , DAVID L LEWIS , PHILIPP HADWIGER , ERIC A KITAS , INGO ROEHL , TORSTEN HOFFMANN , KERSTIN JAHN-HOFMANN , HANS MARTIN MUELLER , GUENTHER OTT
IPC: A61K31/713 , A61K47/18 , C12N15/11 , C12N15/87
Abstract: La presente invención se refiere a un conjugado preparado por un proceso caracterizado porque comprende conjugar un oligonucleótido con un compuesto de fórmula (III): en donde el oligonucleótido es un oligonucléotido de hebra individual, antisentido con por lo menos un nucleótido que no es de origen natural; y en donde el nucleótido que no es natural es ácido nucleico trabado (LNA).
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公开(公告)号：BRPI0005616B1
公开(公告)日：2017-12-12
申请号：BRPI0005616
申请日：2000-11-28
Applicant: HOFFMANN LA ROCHE
Inventor： ANDREW SLEIGHT , GUY ANDREW HIGGINS , SONIA MARIA POLI , THERESA MARIA BALLARD , TORSTEN HOFFMANN
IPC: C07D213/74 , C07D413/04 , A61K31/00 , A61K31/4427 , A61K31/5377 , A61P1/06 , A61P1/08 , A61P25/00 , A61P25/22 , A61P25/24 , A61P43/00 , C07D213/00 , C07D213/75 , C07D265/00
Abstract: patente de invenção: "2-(3,5-bis-trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida" . a invenção refere-se ao composto da fórmula o qual é a 2-(3,5-bis-trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida. foi verificado que este composto tem uma alta afinidade pelo receptor para nk-1 e é, portanto, útil no tratamento de doenças que se relacionam a este receptor.
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公开(公告)号：ZA200510453B
公开(公告)日：2007-01-31
申请号：ZA200510453
申请日：2005-12-22
Applicant: HOFFMANN LA ROCHE
Inventor： TORSTEN HOFFMANN , JENS-UWE PETERS , ANDREW SLEIGHT , ANDREAS KOBLET , PATRICK SCHNIDER , HEINZ STADLER
IPC: A61K20090101 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , A61K31/4995 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/547 , A61K31/551 , A61K31/554 , C07D20090101 , C07D213/75 , C07D401/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D451/04 , C07D487/08 , C07D491/10 , C07D495/10 , C07D497/10 , C07D498/08 , C07D513/08
Abstract: The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In particular, the invention provides methods for treating both positive and negative symptoms of schizophrenia through dual inhibition of NK1 and NK3 receptors. The invention also provides novel compounds with formula I and methods for preparing compounds of the invention.
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公开(公告)号：PT1385577E
公开(公告)日：2006-08-31
申请号：PT02719751
申请日：2002-02-02
Applicant: HOFFMANN LA ROCHE
Inventor： SUSANNE BUSER , FORD ANTHONY P D W , TORSTEN HOFFMANN , BARBARA LENZ , JOHN SLEIGHT ANDREW , PIERRE VANKAN
IPC: A61K31/44 , A61K31/455 , A61K31/5377 , A61K31/541 , C07D213/75 , A61K45/00 , A61P13/08 , A61P43/00 , A61P13/00
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Patent Agency Ranking
公开(公告)号：JO2321B1
公开(公告)日：2005-09-12
申请号：JOP20010117
申请日：2001-07-17
Applicant: HOFFMANN LA ROCHE
Inventor： TORSTEN HOFFMANN , PATRICK SCHNIDER , HINZ STADLER
IPC: A61K31/4409 , A61K31/4427 , A61K31/455 , A61K31/465 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/08 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/00 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/36 , A61P27/02 , A61P29/00 , A61P43/00 , C07D213/75 , C07D213/82 , C07D401/04 , C07D413/04 , C07D521/00
Abstract: The invention relates to compounds of the general formula Wherein R1 is NH(CH2)2OH- NR3C(O)CH3 OR NR3C(O)-cyclopropyl R2 is methyl or chloro R3 is hydrogen or methyl R is hydrogen or (CH2) 2OH , and N is 1 or 2 And pharmaceutically acceptable acid addition salts thereof , these compounds have a good affinity to the NK-1 receptor and therefore they may be used in the treatment or prevention of diseases , related to this receptor.
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公开(公告)号：JO2321B
公开(公告)日：2005-09-12
申请号：JO2001117
申请日：2001-07-17
Applicant: HOFFMANN LA ROCHE
Inventor： TORSTEN HOFFMANN , PATRICK SCHNIDER , HINZ STADLER
IPC: A61K31/4409 , A61K31/4427 , A61K31/455 , A61K31/465 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/08 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/00 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/36 , A61P27/02 , A61P29/00 , A61P43/00 , C07D213/75 , C07D213/82 , C07D401/04 , C07D413/04 , C07D521/00
CPC classification number: C07D213/75 , C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D413/04
Abstract: The invention relates to compounds of the general formula Wherein R1 is NH(CH2)2OH- NR3C(O)CH3 OR NR3C(O)-cyclopropyl R2 is methyl or chloro R3 is hydrogen or methyl R is hydrogen or (CH2) 2OH , and N is 1 or 2 And pharmaceutically acceptable acid addition salts thereof , these compounds have a good affinity to the NK-1 receptor and therefore they may be used in the treatment or prevention of diseases , related to this receptor.
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公开(公告)号：HK1046411B
公开(公告)日：2005-05-27
申请号：HK02108020
申请日：2002-11-05
Applicant: HOFFMANN LA ROCHE
Inventor： MICHAEL BOES , GUIDO GALLEY , THIERRY GODEL , TORSTEN HOFFMANN , WALTER HUNKELER , PATRICK SCHNIDER , HEINZ STADLER
IPC: C07D20060101 , A61K20060101 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61P20060101 , A61P1/04 , A61P1/08 , A61P9/00 , A61P11/02 , A61P11/06 , A61P17/02 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P37/08 , A61P43/00 , C07D213/00 , C07D239/00 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/46 , C07D239/48 , C07D295/00 , C07D401/04
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公开(公告)号：MA26559A1
公开(公告)日：2004-12-20
申请号：MA25327
申请日：1998-10-30
Applicant: HOFFMANN LA ROCHE
Inventor： CORNELIA HERTEL , ROLAND JAKOB-ROETNE , ROGER DAVID NORCROSS , TORSTEN HOFFMANN
IPC: C07K5/078 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K38/08 , A61P3/00 , A61P3/10 , A61P9/04 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00 , C07D207/16 , C07D207/22 , C07D207/277 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D521/00 , C07D513/16
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公开(公告)号：HK1045684B
公开(公告)日：2004-11-26
申请号：HK02107102
申请日：2002-09-26
Applicant: F HOFFMANN-LA ROCHE AG [CH/CH]
Inventor： MICHAEL BOES , GUIDO GALLEY , THIERRY GODEL , TORSTEN HOFFMANN , WALTER HUNKELER , PATRICK SCHNIDER , HEINZ STADLER
IPC: C07C20060101 , C07D295/14 , A61K20060101 , A61K31/166 , A61K31/167 , A61K31/495 , A61K31/496 , A61P1/04 , A61P1/08 , A61P11/06 , A61P25/24 , A61P25/28 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/01 , C07C43/174 , C07C209/06 , C07C209/50 , C07C211/29 , C07C211/45 , C07C217/54 , C07C231/02 , C07C231/08 , C07C233/11 , C07C233/15 , C07C233/44 , C07C233/66 , C07C235/42 , C07D295/155
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