公开(公告)号：KR800001143B1

公开(公告)日：1980-10-14

申请号：KR770001711

申请日：1977-07-25

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  SCHNEIDER F ,  WERTNER K ,  SCHMITT H

IPC: C07D207/09

Abstract: Title compds. (I; R1 = 2-thienyl or phenyl substuted with lower t-amino group, R2 and R3 are independently, H or lower alkyl; R4 = halogen, lower alkyl, lower alkoxy, nitro, phenyl), useful as anaesthetics, were prepd. by reduction of compd. II in the presence of catalyst. Thus, 17 g 2-(P-methoxy-phenyl)-5, 5-dimethyl-4-(2-thienyl)-1-pyrroline and 10 g sodium borohydride were reacted in 250 ml anhydrous ethanol gor 6 hr with N2 gas to give cis-5-(p-methoxyphenyl)-2, 2-dimethyl-3-(2-thienyl)-pyrrolidine hydrochloric acid salt (m.p. 180oC).