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    METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID
    2.
    发明专利
    METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID 未知

    公开(公告)号：CA3000297C

    公开(公告)日：2021-11-02

    申请号：CA3000297

    申请日：2016-11-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： IBACH ALEXANDER ,  RINGEMANN CHRISTIAN ,  STEPHAN PETER

    IPC: G01N33/52 ,  G01N21/84

    Abstract: The invention concerns a method and an apparatus for determining the concentration of an analyte in a body fluid, where the following measures are proposed: providing a layered test element (12) including an enzyme-based chemistry layer which is responsive to the analyte by a color change, applying a sample of the body fluid onto the test element (12), detecting by means of a photometric reflectance measuring device (16) a reflectance value of the test element (12), correcting the measured reflectance value by a predetermined offset value attributed to the test element (12), determining a concentration value of the analyte using the offset- corrected reflectance value.

    CONTROL-TO-RANGE AGGRESSIVENESS
    3.
    发明专利
    CONTROL-TO-RANGE AGGRESSIVENESS 未知

    公开(公告)号：CA3025906A1

    公开(公告)日：2017-12-07

    申请号：CA3025906

    申请日：2017-05-09

    Applicant: HOFFMANN LA ROCHE

    Inventor： DUKE DAVID L ,  GREENBURG ALAN ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY

    IPC: A61M5/172 ,  A61B5/145 ,  G16H20/10 ,  G16H50/20

    Abstract: A method and system of determining a basal rate adjustment of insulin in a continuous glucose monitoring system of a person with diabetes is provided. The method includes receiving, by at least one computing device, a signal representative of at least one glucose measurement; detecting, by the at least one computing device, a glucose state of the person based on the signal, the detected glucose state including a glucose level of the person and a rate of change of the glucose level; determining, by the at least one computing device, a current risk metric, the current risk metric indicating a risk of at least one of a hypoglycemic condition and a hyperglycemic condition of the person; and calculating, by the at least one computing device, an adjustment to a basal rate of a therapy delivery device based on the current risk metric and a control-to-range algorithm comprising at least one aggressiveness parameter.

    METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID
    4.
    发明专利
    METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID 未知

    公开(公告)号：CA3000297A1

    公开(公告)日：2017-06-01

    申请号：CA3000297

    申请日：2016-11-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： IBACH ALEXANDER ,  RINGEMANN CHRISTIAN ,  STEPHAN PETER

    IPC: G01N33/52 ,  G01N21/84

    Abstract: The invention concerns a method and an apparatus for determining the concentration of an analyte in a body fluid, where the following measures are proposed: providing a layered test element (12) including an enzyme-based chemistry layer which is responsive to the analyte by a color change, applying a sample of the body fluid onto the test element (12), detecting by means of a photometric reflectance measuring device (16) a reflectance value of the test element (12), correcting the measured reflectance value by a predetermined offset value attributed to the test element (12), determining a concentration value of the analyte using the offset- corrected reflectance value.

    Método para detectar una contribución interferente en un biosensor
    7.
    发明专利
    Método para detectar una contribución interferente en un biosensor 未知

    公开(公告)号：ES2720780T3

    公开(公告)日：2019-07-24

    申请号：ES16160136

    申请日：2016-03-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： RINGEMANN CHRISTIAN ,  WIEDER HERBERT

    IPC: G01N27/327 ,  C12Q1/00

    Abstract: Un método para detectar una contribución interferente utilizando un modo de detección de interferente dentro de un biosensor, en el que el biosensor tiene un primer electrodo (112), un segundo electrodo y un tercer electrodo (114), en donde el primer electrodo (112) y el segundo electrodo están cubiertos por una membrana, en donde el primer electrodo (112) incluye además una enzima o en donde el primer electrodo (112) está cubierto por una capa de enzima, en donde el primer electrodo (112), el segundo electrodo y el tercero electrodo (114) están conectados mediante un potenciostato, en el que, en un modo de funcionamiento normal, a través del potenciostato, se aplica una diferencia de potencial eléctrico entre el primer electrodo (112). y el segundo electrodo de manera que el primer electrodo (112) permite procesos oxidativos y el tercer electrodo (114) permite procesos reductivos, el método comprende los pasos de: a) cambiar del modo operativo normal al modo de detección interferente , en el que, en el modo de detección de interferente, la diferencia de potencial eléctrico entre el primer electrodo (112) y el segundo electrodo se altera por un período de tiempo limitado de una manera que el tercer electrodo (114) permite procesos oxidativos; b) medir una característica de corriente-voltaje (110) del tercer electrodo (114); y c) determinar la contribución interferente mediante la evaluación de la característica de corriente-voltaje (110) del tercer electrodo (114).

    Control-to-range aggressiveness
    8.
    发明专利
    Control-to-range aggressiveness 未知

    公开(公告)号：AU2017275392A1

    公开(公告)日：2019-01-03

    申请号：AU2017275392

    申请日：2017-05-09

    Applicant: HOFFMANN LA ROCHE

    Inventor： DUKE DAVID L ,  GREENBURG ALAN ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY

    Abstract: A method and system of determining a basal rate adjustment of insulin in a continuous glucose monitoring system of a person with diabetes is provided. The method includes receiving, by at least one computing device, a signal representative of at least one glucose measurement; detecting, by the at least one computing device, a glucose state of the person based on the signal, the detected glucose state including a glucose level of the person and a rate of change of the glucose level; determining, by the at least one computing device, a current risk metric, the current risk metric indicating a risk of at least one of a hypoglycemic condition and a hyperglycemic condition of the person; and calculating, by the at least one computing device, an adjustment to a basal rate of a therapy delivery device based on the current risk metric and a control-to-range algorithm comprising at least one aggressiveness parameter.

    RISK-BASED CONTROL-TO-RANGE
    10.
    发明专利
    RISK-BASED CONTROL-TO-RANGE 未知

    公开(公告)号：CA3025874A1

    公开(公告)日：2017-12-07

    申请号：CA3025874

    申请日：2017-05-09

    Applicant: HOFFMANN LA ROCHE

    Inventor： DUKE DAVID L ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY ,  GREENBURG ALAN

    IPC: A61M5/172 ,  A61B5/145 ,  G16H20/10 ,  G16H50/20

    Abstract: Methods and systems are disclosed for determining a basal rate adjustment of insulin based on risk associated with a glucose state of a person with diabetes. A method may include detecting a glucose state of the person based on a received glucose measurement signal and determining a current risk metric associated with the detected glucose state. The method may include determining a current risk metric associated with the detected glucose state based on a weighted average of cumulative hazard values of return paths generated from a glucose state distribution around a detected glucose state. The method may include calculating an adjustment to a basal rate of a therapy delivery device based on the current risk metric associated with the detected glucose state and a reference risk metric associated with a reference glucose level.

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