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    PROCESS FOR THE SEPARATION OF ENANTIOMERS
    1.
    发明申请
    PROCESS FOR THE SEPARATION OF ENANTIOMERS 审中-公开
    分离器的过程

    公开(公告)号：WO2004052883A3

    公开(公告)日：2005-01-13

    申请号：PCT/US0340067

    申请日：2003-12-04

    Applicant: HONEYWELL INT INC

    Inventor： WILKEN JOERG ,  KANSCHIK-CONRADSEN ANDREAS ,  NERENZ FRANK

    IPC: C07B57/00 ,  C07C51/02 ,  C07C51/09 ,  C07C51/41 ,  C07C51/43 ,  C07D405/12

    CPC classification number: C07D405/12 ,  C07B57/00 ,  C07C51/02 ,  C07C51/09 ,  C07C51/412 ,  C07C51/43 ,  C07C59/48

    Abstract: In a process comprising synthesizing pyranes including [R-(R*,R*)]-N-[3-[1 [5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3- yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises the improvements comprising: (a) providing a racemic mixture of 3-hydroxy- 3-(2-phenylethyl)-hexanoate ethyl acetate by reacting said 1-phenyl-hexan-3-one with ethylbromoacetate under Reformatsky conditions; and (b) separating (R)-3-hydroxy-3- (2-phenylethyl)-hexanoic acid in enantiomeric excess by saponification and reverse resolution of the racemate of step (a) to produce a resolved product. In addition, the present invention comprises a reverse resolution process for separating an enantiomer from a mixture of enantiomers.

    Abstract translation: 在包括合成包括[R-（R *，R *）] - N- [3- [1,5-二羟基-4-羟基-2-氧代-6-（2-苯乙基）-6 - 丙基-2H-吡喃-3-基]丙基]苯基] -5-（三氟甲基）-2-吡啶磺酰胺本发明包括以下改进：（a）提供3-羟基-3-（2- 苯乙基） - 己酸乙酯，通过在Reformatsky条件下使所述1-苯基 - 己-3-酮与溴乙酸乙酯反应; 和（b）通过步骤（a）的外消旋物的皂化和反向拆分来分离对映异构体过量的（R）-3-羟基-3-（2-苯基乙基） - 己酸，得到分离产物。 此外，本发明包括从对映异构体的混合物中分离对映异构体的逆分辨方法。

    2.
    发明专利
    未知

    公开(公告)号：DE06790055T1

    公开(公告)日：2008-09-25

    申请号：DE06790055

    申请日：2006-08-28

    Applicant: HONEYWELL INT INC

    Inventor： SIEGGEL ALFRED ,  NERENZ FRANK ,  PALANISAMY THIRUMALAI ,  POSS ANDREW ,  DEMEL SONJA

    IPC: C07D487/10 ,  C07D471/10 ,  C07D471/20 ,  C07D487/20 ,  C07D498/10

    Abstract: A method for preparing a spiro quaternary ammonium system and electrolytes containing spiro quaternary ammonium cations, comprising a synthesizing step wherein a spiro ammonium system is formed in a medium that can serve as both the reaction solvent and as an electrolyte solvent. A one-solution method of making a non-aqueous electrolyte composition that comprises at least one of a spiro quaternary ammonium compound of the following formula:

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