公开(公告)号：US20020010400A1

公开(公告)日：2002-01-24

申请号：US09853298

申请日：2001-05-10

Applicant: HOSPITAL FOR SPECIAL SURGERY

Inventor： Nancy P. Camacho ,  Mathias P.B. Bostrom ,  Paul West

IPC: A61B006/00

CPC classification number: A61B6/032 ,  A61B6/4028 ,  A61B6/4085 ,  G01N21/35 ,  G01N21/359

Abstract: A method for the evaluation of the ultrastructure of connective tissue, such as cartilage, including (a) providing a probe operative in the near-infrared or mid-infrared region of the electromagnetic spectrum, (b) positioning the probe either to be in contact with the connective tissue (for detecting attenuated total reflectance) or within a sufficient distance from the surface of the connective tissue (for detecting reflection), (c) detecting infrared radiation which penetrates the surface of the connective tissue for detecting attenuated total reflectance or which reflects off the surface of the connective tissue and (d) analyzing the infrared radiation from step (c) for at least one of peak height, peak area and frequency, and comparing at least one of the peak height, the peak area and the frequency for established values for at least one of peak height, peak area and frequency for normal connective tissue to detect a modification in the molecular structure of the connective tissue.

Abstract translation: 一种用于评估诸如软骨的结缔组织超微结构的方法，包括（a）提供在电磁光谱的近红外或中红外区域中操作的探针，（b）将探针定位成接触 （用于检测衰减的总反射率）或距离结缔组织表面足够的距离（用于检测反射），（c）检测穿透结缔组织表面的红外辐射，以检测衰减的总反射率或哪些 反射出结缔组织的表面，（d）分析峰高，峰面积和频率中的至少一个峰步骤（c）的红外辐射，并比较峰高，峰面积和频率中的至少一个 对于正常结缔组织的峰高，峰面积和频率中至少一个的建立值，以检测结缔组织分子结构的修饰 。