公开(公告)号：US20020010400A1

公开(公告)日：2002-01-24

申请号：US09853298

申请日：2001-05-10

Applicant: HOSPITAL FOR SPECIAL SURGERY

Inventor： Nancy P. Camacho ,  Mathias P.B. Bostrom ,  Paul West

IPC: A61B006/00

CPC classification number: A61B6/032 ,  A61B6/4028 ,  A61B6/4085 ,  G01N21/35 ,  G01N21/359

Abstract: A method for the evaluation of the ultrastructure of connective tissue, such as cartilage, including (a) providing a probe operative in the near-infrared or mid-infrared region of the electromagnetic spectrum, (b) positioning the probe either to be in contact with the connective tissue (for detecting attenuated total reflectance) or within a sufficient distance from the surface of the connective tissue (for detecting reflection), (c) detecting infrared radiation which penetrates the surface of the connective tissue for detecting attenuated total reflectance or which reflects off the surface of the connective tissue and (d) analyzing the infrared radiation from step (c) for at least one of peak height, peak area and frequency, and comparing at least one of the peak height, the peak area and the frequency for established values for at least one of peak height, peak area and frequency for normal connective tissue to detect a modification in the molecular structure of the connective tissue.

Abstract translation: 一种用于评估诸如软骨的结缔组织超微结构的方法，包括（a）提供在电磁光谱的近红外或中红外区域中操作的探针，（b）将探针定位成接触 （用于检测衰减的总反射率）或距离结缔组织表面足够的距离（用于检测反射），（c）检测穿透结缔组织表面的红外辐射，以检测衰减的总反射率或哪些 反射出结缔组织的表面，（d）分析峰高，峰面积和频率中的至少一个峰步骤（c）的红外辐射，并比较峰高，峰面积和频率中的至少一个 对于正常结缔组织的峰高，峰面积和频率中至少一个的建立值，以检测结缔组织分子结构的修饰 。

公开(公告)号：US20020169379A1

公开(公告)日：2002-11-14

申请号：US10142003

申请日：2002-05-09

Applicant: HOSPITAL FOR SPECIAL SURGERY

Inventor： Nancy P. Camacho ,  Mathias P.G. Bostrom ,  Steve L. Bertha

IPC: A61B005/00 ,  A61B017/22

CPC classification number: G01N21/552 ,  A61B5/0059 ,  A61B5/4504 ,  G01N21/35 ,  G01N21/359 ,  G01N2021/559 ,  G01N2201/0846

Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法，包括（a）将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率，或者在 距离用于检测反射的区域的表面足够的距离，（b）检测中间或近红外辐射减弱了样品或材料表面的全反射或反射，（c）分析来自步骤（b）的红外辐射 ），用于峰高，峰面积，频率和化学计量参数中的至少一个，以及（d）当来自红外光纤探针的信号处于峰值高度，峰值面积之中的至少一个的预选值之间时，启动去除装置 ，样品的频率和化学计量参数。