公开(公告)号：US20240192242A1

公开(公告)日：2024-06-13

申请号：US18287902

申请日：2022-03-10

Applicant: Hitachi High-Tech Corporation

Inventor： Sumiaki MATSUO ,  Shinya MATSUOKA

IPC: G01N35/04

CPC classification number: G01N35/04

Abstract: To provide an automatic analyzer capable of preventing stacking of used reaction containers more easily than in the related art while achieving space saving. An automatic analyzer 1 includes: a plurality of reaction containers 14 each configured to hold a reaction liquid; a reaction container tray lifting mechanism 21B configured to convey a reaction container tray 7 that holds the reaction containers 14 before use; and a reaction container disposal unit 26 to which the used reaction container 14 is to be disposed of, and the reaction container disposal unit 26 includes a coupling portion configured to be in contact with the reaction container tray lifting mechanism 21B and configured to convert an operation of the reaction container tray lifting mechanism 21B into an exciting force exerted on the reaction container disposal unit 26.

公开(公告)号：US20240066426A1

公开(公告)日：2024-02-29

申请号：US18272150

申请日：2022-01-06

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Mayuko ITO ,  Shinya MATSUOKA

IPC: B01D1/00

CPC classification number: B01D1/0082

Abstract: An evaporation concentration mechanism is realized that can control a depressurization rate by an inexpensive and simple mechanism to inhibit bumping at the time of evaporation and concentration. The evaporation concentration mechanism includes a reaction vessel that holds a sample solution, a depressurization channel connected to the reaction vessel, and a depressurization source that is connected to the reaction vessel via the depressurization channel and depressurizes the inside of the reaction vessel. The evaporation concentration mechanism further includes at least one of solenoid valves provided in the depressurization channel, and a control unit 8 that controls an operation of the solenoid valves. The control unit 8 intermittently opens and closes the solenoid valves during a depressurization period in which the inside of the reaction vessel is depressurized by the depressurization source.

公开(公告)号：US20240402205A1

公开(公告)日：2024-12-05

申请号：US18699866

申请日：2022-10-11

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Mayuko ITO ,  Shinya MATSUOKA ,  Daisuke EBIHARA

IPC: G01N35/10 ,  G01N1/10 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: To relax restrictions, which are associated with the access of a transfer mechanism and a nozzle to the same installation location, on an operation time chart of an automatic analyzer. In a control method of an automatic analyzer according to the present disclosure: the automatic analyzer is configured so that a transport mechanism of a container and a nozzle may not be simultaneously accessible to an installation part of the container; and the transport mechanism installs a second container to the installation part before the nozzle discharges a liquid to the second container installed at the installation part after the nozzle aspirates the liquid from a first container installed at the installation part.

公开(公告)号：US20240201218A1

公开(公告)日：2024-06-20

申请号：US18555737

申请日：2022-01-27

Applicant: Hitachi High-Tech Corporation

Inventor： Mayuko ITO ,  Shinya MATSUOKA

IPC: G01N35/10

CPC classification number: G01N35/1004 ,  G01N35/1002

Abstract: Provided is an automatic analyzer capable of preventing precipitation of a solute in a cleaning liquid in a reservoir used for cleaning a dispensing probe. The automatic analyzer for analyzing a sample includes a dispensing probe configured to dispense the sample or a reagent, a reservoir configured to reserve a cleaning liquid used for cleaning the dispensing probe, a flow path connected to the reservoir and through which the cleaning liquid flows, and a control unit configured to control each unit. The control unit draws the cleaning liquid in the reservoir into the flow path, and then supplies system water to the reservoir.

公开(公告)号：US20230184801A1

公开(公告)日：2023-06-15

申请号：US17915957

申请日：2021-01-15

Applicant: Hitachi High-Tech Corporation

Inventor： Ruochi HSU ,  Nobuhiro TSUKADA ,  Kazuhiro NODA ,  Shinya MATSUOKA

IPC: G01N35/10

CPC classification number: G01N35/1009 ,  G01N35/1002

Abstract: [Problem to be solved]
There is provided a dispensing control method and a dispenser that suppress the division of an air layer and that obtain high dispensing accuracy.
[Solution]
An automatic analyzer includes: a nozzle 20 that dispenses a dispensed liquid 23; a syringe motor 209 that generates a pressure fluctuation for controlling a flow velocity on aspiration or discharge of the dispensed liquid 23 in the nozzle 20; a piping 210 that connects the nozzle 20 to the syringe motor 209; and a controller 102 that controls operations of the nozzle 20 and the syringe motor 209. The controller 102 calculates positions of interfaces 31 to 34 in the piping 210, and the controller 102 controls the flow velocity based on the positions of the interface 31 to 34 and orientations of the interfaces 31 to 34 that move.

公开(公告)号：US20220276270A1

公开(公告)日：2022-09-01

申请号：US17601469

申请日：2020-03-09

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Makoto NOGAMI ,  Shinya MATSUOKA ,  Daisuke EBIHARA ,  Yuichiro HASHIMOTO

IPC: G01N35/00

Abstract: A pretreatment method of an automatic analyzer, in which pretreatments of a plurality of substances to be measured can be performed by a series of treatments using a plurality of magnetic beads that can bind to the plurality of substances to be measured, is achieved. In the pretreatment method of an automatic analyzer, a magnetic bead is added to a sample containing a substance to be measured, the substance to be measured is bound to the magnetic bead, the magnetic bead is extracted from the sample, and the substance to be measured is separated from the magnetic bead by an eluate. A plurality of magnetic beads that bind to a plurality of types of substances to be measured are added to a sample, and the plurality of types of substances to be measured are extracted from the magnetic bead by an eluate.

公开(公告)号：US20220107293A1

公开(公告)日：2022-04-07

申请号：US17432538

申请日：2020-02-25

Applicant: Hitachi High-Tech Corporation

Inventor： Makoto NOGAMI ,  Daisuke AKIEDA ,  Shinya MATSUOKA ,  Shinya ITO

IPC: G01N30/46 ,  G01N30/30

Abstract: An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed. Holding time information of the same verification flow paths 122 and 123 in the stream 101 and the stream 102 are compared with holding time information stored in the control unit 130 and correction is performed when the difference in holding time is 1 second or more.

公开(公告)号：US20250003997A1

公开(公告)日：2025-01-02

申请号：US18710305

申请日：2022-10-28

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Shingo OHTA ,  Taichiro YAMASHITA ,  Takumi ITO ,  Shinya MATSUOKA ,  Mayuko ITO ,  Susumu SAKAIRI

IPC: G01N35/00

Abstract: Provided is an automatic analyzer capable of reducing bumping of a liquid sample. The automatic analyzer includes a reaction container, a heating member, an exhaust unit, and a reaction container moving member. The automatic analyzer executes a first evaporative concentration step in which the exhaust unit aspirates vapor in the reaction container and the heating member heats the reaction container with a first heat quantity in a state where the reaction container is at a separation position, and a second evaporative concentration step in which the exhaust unit aspirates vapor in the reaction container and the heating member heats the reaction container with a second heat quantity larger than the first heat quantity in a state where the reaction container is at a contact position.

公开(公告)号：US20240210364A1

公开(公告)日：2024-06-27

申请号：US18287483

申请日：2022-02-03

Applicant: Hitachi High-Tech Corporation

Inventor： Daisuke AKIEDA ,  Yushi HARADA ,  Shoji TOMIDA ,  Shinya MATSUOKA ,  Yuichiro HASHIMOTO

IPC: G01N30/38 ,  G01N30/02 ,  G01N30/16 ,  G01N30/86

CPC classification number: G01N30/38 ,  G01N30/16 ,  G01N2030/027 ,  G01N2030/385 ,  G01N30/8675

Abstract: To provide a liquid chromatograph and a liquid delivery method capable of more easily and reliably removing bubbles mixed during mobile phase installation or replacement operation. The liquid chromatograph includes: supply pipes configured to connect a liquid delivery device and a liquid storage container; a circulation pipe configured to connect an intermediate portion of the supply pipe and the liquid storage container; a flow passage switching valve provided on a connection portion between the supply pipe and the circulation pipe and configured to selectively switch between a liquid delivery state in which the supply pipe on the liquid storage container side and the supply pipe on the liquid delivery device side communicate with each other and a circulation state in which the supply pipe and the circulation pipe on the liquid storage container side communicate with each other; a bubble detection device provided on the supply pipe between the liquid storage container and the flow passage switching valve; and a circulation liquid delivery device provided on the circulation pipe. A control device is configured to switch the flow passage switching valve to the circulation state to perform a circulation liquid delivery by the circulation liquid delivery device, and switch the flow passage switching valve to the liquid delivery state when the bubbles are not detected by the bubble detection device.

公开(公告)号：US20230139301A1

公开(公告)日：2023-05-04

申请号：US17910927

申请日：2021-02-03

Applicant: Hitachi High-Tech Corporation

Inventor： Daisuke EBIHARA ,  Shinya MATSUOKA

IPC: G01N35/10 ,  G01N35/00

Abstract: To provide an automatic analyzer capable of relaxing the effect of a previously created mixed liquid when a new mixed liquid is created. An automatic analyzer according to the present disclosure: is configured so as to create a second mixed liquid after a first mixed liquid is created; and introduces a relaxation reagent to relax the effect of a first reagent remaining in a mixed liquid chamber when the second mixed liquid is created into the mixed liquid chamber on the basis of characteristics of the first mixed liquid.