公开(公告)号：EP2895526A4

公开(公告)日：2016-03-09

申请号：EP13837540

申请日：2013-09-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： CHENG WEI ,  COADY DANIEL J ,  ENGLER AMANDA C ,  HEDRICK JAMES L ,  TEO PEI YUN ,  YANG CHUAN ,  YANG YI YAN

IPC: C08G73/02 ,  A61K47/48 ,  A61K48/00

CPC classification number: C12N15/85 ,  C08G73/028

Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n′+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L′ is a divalent radical comprising 3 to 30 carbons, and q/(n′+q)×100% equals about 9% to about 47%.

Abstract translation: 支链多胺包括约45至约70个骨架叔胺基团，约90至约140个主链仲胺基团，正数n'大于0的主链终止伯胺基团，正数q大于0的骨架终止 式（2）的氨基甲酸酯基团：其中（n'+ q）为等于约45至约70的数，式（2）的星形键与支链多胺的主链氮连接，L'是二价 包含3至30个碳的基团，q /（n'+ q）×100％等于约9％至约47％。

公开(公告)号：EP3076955A4

公开(公告)日：2017-08-02

申请号：EP14868495

申请日：2014-12-03

Applicant: IBM ,  AGENCY SCIENCE TECH & RES ,  UNIV DEL PAIS VASCO-EUSKAL HERRIKO UNIBERTSITATEA

Inventor： CHAN JULIAN M W ,  ENGLER AMANDA C ,  HEDRICK JAMES L ,  KE XIYU ,  NG VICTOR W L ,  SARDON HARIZ ,  TAN JEREMY P K ,  YANG YI YAN

IPC: A61K9/51 ,  A61K31/704 ,  A61K31/7088 ,  A61K38/00 ,  A61K47/34 ,  C08G64/02 ,  C08G64/16 ,  C08G64/18 ,  C08L69/00

CPC classification number: A61K47/34 ,  A61K9/5146 ,  A61K31/704 ,  A61K31/713 ,  A61K38/00 ,  A61K38/16 ,  C08G64/0241 ,  C08G64/183 ,  C08L69/00

Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

Abstract translation: 纳米颗粒包含药物，第一嵌段聚合物和第二嵌段聚合物。 第一嵌段聚合物具有聚（环氧乙烷）（PEO）嵌段和带有侧链芳族含氮杂环（N-杂环）的聚碳酸酯嵌段。 N-杂环可以是碱的形式，碱的氢硫酸盐，碱的磺基甜菜碱加合物或其组合。 第二嵌段聚合物具有PEO嵌段和具有侧链儿茶酚基团的聚碳酸酯嵌段，其可以儿茶酚，邻苯二酚的氧化形式和/或儿茶酚的聚合形式存在。 纳米颗粒可以分散在水中并且能够控制药物的释放。

公开(公告)号：EP3313914A4

公开(公告)日：2018-06-20

申请号：EP16814830

申请日：2016-06-27

Applicant: AGENCY FOR SCIENCE TECH AND RESEARCH ,  INT BUSINESS MACHINES CORPORATION IBM

Inventor： CHAN JULIAN M W ,  ONO ROBERT J ,  YANG YI YAN ,  HEDRICK JAMES L ,  TEO JYE YNG ,  ZHANG MU SAN

IPC: C08G73/00 ,  A01N33/12 ,  A61K8/00 ,  A61K31/785 ,  C08K5/17

CPC classification number: A01N33/12 ,  C08G73/02 ,  C08G73/0206 ,  C08G73/0213 ,  C08G73/024 ,  A01N25/10

Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.

公开(公告)号：EP2895527A4

公开(公告)日：2016-04-20

申请号：EP13837806

申请日：2013-09-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： CHENG WEI ,  COADY DANIEL J ,  ENGLER AMANDA C ,  HEDRICK JAMES L ,  TEO PEI YUN ,  YANG CHUAN ,  YANG YI YAN

IPC: C08G73/02 ,  A61K47/48 ,  C08L79/02

CPC classification number: C08G73/0206

公开(公告)号：JP2010159418A

公开(公告)日：2010-07-22

申请号：JP2010023779

申请日：2010-02-05

Applicant: Board Of Trustees Of The Leland Stanford Junior Univ ,  Internatl Business Mach Corp ,  インターナショナル・ビジネス・マシーンズ・コーポレーションInternational Business Maschines Corporation ,  ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー

Inventor： HEDRICK JAMES L ,  KILICKIRAN PINAR ,  NYCE GREGORY W ,  WAYMOUTH ROBERT M

IPC: C08J11/28 ,  B01J31/02 ,  B01J31/22 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/16 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00

CPC classification number: C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

Abstract: PROBLEM TO BE SOLVED: To provide an improved method for carrying out depolymerization of a polymer. SOLUTION: The method is provided for carrying out depolymerization of the polymer containing an electrophilic linkage in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80°C or lower, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种进行聚合物解聚的改进方法。 解决方案：该方法用于在催化剂和亲核试剂的存在下进行含有亲电键的聚合物的解聚，其中由聚合物降解产生的不期望的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保解聚产物基本上不含金属污染物。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO2015187695A3

公开(公告)日：2016-09-29

申请号：PCT/US2015033788

申请日：2015-06-02

Applicant: IBM

Inventor： BODAY DYLAN J ,  GARCIA JEANNETTE M ,  HEDRICK JAMES L ,  WOJTECKI RUDY J

IPC: C08L81/10

CPC classification number: C08G75/20 ,  C08G73/0253 ,  C08L79/04 ,  C08L81/06

Abstract: Polysulfones and methods for forming polysulfones are disclosed herein. The polysulfones are prepared from thiols and hexahydrotriazines. The thiols may be, for example, dithiols, trithiols, monothiols, or mixtures thereof. The thiols and hexahydrotriazines may be polymerized to form a polythioether. The polythioether may thereafter be oxidized to form a polysulfone. The polysulfones are prepared from an efficient and simple synthetic method, and the properties of the prepared polysulfones can be readily tuned. The prepared polysulfones may have improved thermal properties, improved mechanical properties, and enhanced functionality.

Abstract translation: 本文公开了聚砜和形成聚砜的方法。 聚砜由硫醇和六氢三嗪制备。 硫醇可以是例如二硫醇，三硫醇，单硫醇或其混合物。 硫醇和六氢三嗪可以聚合形成聚硫醚。 此后，聚硫醚可被氧化形成聚砜。 聚砜通过有效和简单的合成方法制备，并且可以容易地调节制备的聚砜的性质。 制备的聚砜可具有改进的热性能，改进的机械性能和增强的功能性。

公开(公告)号：WO2004060987A3

公开(公告)日：2004-10-07

申请号：PCT/US0341283

申请日：2003-12-23

Applicant: IBM ,  UNIV LELAND STANFORD JUNIOR

Inventor： HEDRICK JAMES L ,  KILICKIRAN PINAR ,  NYCE GREGORY W ,  WAYMOUTH ROBERT M

IPC: C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/16 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C08J11/18 ,  B01J31/22

CPC classification number: C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80°C or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the deploymerization product(s) aer substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

Abstract translation: 提供了一种在催化剂和亲核试剂的存在下进行含有亲电键的聚合物解聚的方法，其中由聚合物降解产生的不需要的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保基本上不含金属污染物的配位产品。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。

公开(公告)号：WO2015195374A4

公开(公告)日：2016-07-28

申请号：PCT/US2015034512

申请日：2015-06-05

Applicant: IBM

Inventor： BODAY DYLAN J ,  GARCIA JEANNETTE M ,  HEDRICK JAMES L ,  WOJTECKI RUDY J ,  JONES GAVIN O

IPC: B01D15/22 ,  C02F5/12 ,  C07D251/04

CPC classification number: B01J20/262 ,  B01D15/08 ,  C02F1/285 ,  C02F1/683 ,  C02F2101/20 ,  C02F2201/002 ,  C02F2303/16

Abstract: Method and apparatus for controlling metals in a liquid are described. The liquid is contacted with a hexahydrotriazine and/or a hemiaminal material, and metal is adsorbed from the liquid onto the material. The hexahydrotriazine and/or hemiaminal material may be made from a diamine and an aldehyde.

Abstract translation: 描述了用于控制液体中的金属的方法和装置。 液体与六氢三嗪和/或半合金材料接触，金属从液体吸附到材料上。 六氢三嗪和/或噻嗪类材料可以由二胺和醛制成。

公开(公告)号：WO2012121985A3

公开(公告)日：2012-11-15

申请号：PCT/US2012027364

申请日：2012-03-02

Applicant: IBM ,  KING ABDULAZIZ CITY SCI & TECH ,  BROCK PHILLIP J ,  COADY DANIEL J ,  FUKUSHIMA KAZUKI ,  HEDRICK JAMES L ,  HORN HANS W ,  RICE JULIA E ,  ALABDULRAHMAN ABDULLAH M ,  ALMEGREN HAMID A ,  ALSEWAILEM FARES D

Inventor： BROCK PHILLIP J ,  COADY DANIEL J ,  FUKUSHIMA KAZUKI ,  HEDRICK JAMES L ,  HORN HANS W ,  RICE JULIA E ,  ALABDULRAHMAN ABDULLAH M ,  ALMEGREN HAMID A ,  ALSEWAILEM FARES D

IPC: C07C67/62 ,  B01J31/02 ,  C07C4/22 ,  C07C69/82 ,  C07C279/00

CPC classification number: C07C67/03 ,  C07C69/82

Abstract: A method comprises forming a reaction mixture comprising a terephthalate polyester, a glycol comprising 2 to 5 carbons, and an amidine organocatalyst; and heating the reaction mixture at a temperature of about 120° C or more to depolymerize the terephthalate polyester, thereby forming a terephthalate reaction product comprising a monomeric dihydroxy terephthalate diester; wherein the terephthalate reaction product contains terephthalate oligomers in an amount less than the amount of terephthalate oligomers that would result from i) substituting the amidine organocatalyst with an equimolar amount of a guanidine catalyst and ii) depolymerizing the terephthalate polyester under otherwise identical reaction conditions.

Abstract translation: 一种方法包括形成包含对苯二甲酸酯聚酯，包含2至5个碳的二醇和脒有机催化剂的反应混合物; 在约120℃或更高的温度下加热反应混合物以解聚对苯二甲酸酯聚酯，由此形成包含单体二羟基对苯二甲酸二酯的对苯二甲酸酯反应产物; 其中所述对苯二甲酸酯反应产物含有的对苯二甲酸酯低聚物的量小于由i）用等摩尔量的胍催化剂取代脒有机催化剂和ii）在其他相同的反应条件下使对苯二甲酸酯聚酯解聚而产生的对苯二甲酸酯低聚物的量。

公开(公告)号：AU2003299913A1

公开(公告)日：2004-07-29

申请号：AU2003299913

申请日：2003-12-23

Applicant: IBM

Inventor： HEDRICK JAMES L ,  KILICKIRAN PINAR ,  NYCE GREGORY W ,  WAYMOUTH ROBERT M

IPC: C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/16 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C08J11/10

Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.