公开(公告)号：GB2605887B

公开(公告)日：2024-08-21

申请号：GB202207247

申请日：2020-10-01

Applicant: IBM

Inventor： BENJAMIN WUNSCH ,  STACEY GIFFORD ,  SUNG-CHEOL KIM ,  JOSHUA SMITH

IPC: B01L3/00 ,  B01J19/00

Abstract: Methods of liquid-phase synthesis of polymers using polymer substrates and systems for facilitating such methods allow gating of a synthetic reaction into a binary (reacted or unreacted) readout. Polymer substrates are used as carriers for molecular reagents and act as separation tags that allow them to be purified using nanoscale deterministic lateral displacement. Two polymer substrates are linked together by a bond-forming reaction to form a longer polymer that includes a synthetic product. The synthetic product can be purified away from unreacted polymers/reagents using strand-length dependent lateral displacement.

公开(公告)号：GB2605887A

公开(公告)日：2022-10-19

申请号：GB202207247

申请日：2020-10-01

Applicant: IBM

Inventor： BENJAMIN WUNSCH ,  STACEY GIFFORD ,  SUNG-CHEOL KIM ,  JOSHUA SMITH

IPC: B01L3/00 ,  B01J19/00

Abstract: Provided are a method and a system for synthesizing molecules, wherein the method comprises: providing a first mixture of core polymers and carrier polymers, the core polymers and the carrier polymers including tether bonds and reagents; forming linking bonds between the core polymers and the carrier polymers, thereby obtaining a second mixture comprising link species including the linking bonds; and separating the link species from the core polymers and the carrier polymers remaining within the second mixture, including: flowing the second mixture through a first nanoDLD array configured to separate the link species from the core polymers and the carrier polymers; and diverting the link species away from the core polymers and the carrier polymers in the first nanoDLD array; and fragmenting the link species.