公开(公告)号：GB2605887A

公开(公告)日：2022-10-19

申请号：GB202207247

申请日：2020-10-01

Applicant: IBM

Inventor： BENJAMIN WUNSCH ,  STACEY GIFFORD ,  SUNG-CHEOL KIM ,  JOSHUA SMITH

IPC: B01L3/00 ,  B01J19/00

Abstract: Provided are a method and a system for synthesizing molecules, wherein the method comprises: providing a first mixture of core polymers and carrier polymers, the core polymers and the carrier polymers including tether bonds and reagents; forming linking bonds between the core polymers and the carrier polymers, thereby obtaining a second mixture comprising link species including the linking bonds; and separating the link species from the core polymers and the carrier polymers remaining within the second mixture, including: flowing the second mixture through a first nanoDLD array configured to separate the link species from the core polymers and the carrier polymers; and diverting the link species away from the core polymers and the carrier polymers in the first nanoDLD array; and fragmenting the link species.

公开(公告)号：GB2583625A

公开(公告)日：2020-11-04

申请号：GB202010486

申请日：2019-01-14

Applicant: IBM

Inventor： JOSHUA THOMAS SMITH ,  STACEY GIFFORD ,  SUNG-CHEOL KIM ,  BENJAMIN HARDY WUNSCH

IPC: C12M1/00

Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid,an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.

公开(公告)号：GB2605887B

公开(公告)日：2024-08-21

申请号：GB202207247

申请日：2020-10-01

Applicant: IBM

Inventor： BENJAMIN WUNSCH ,  STACEY GIFFORD ,  SUNG-CHEOL KIM ,  JOSHUA SMITH

IPC: B01L3/00 ,  B01J19/00

Abstract: Methods of liquid-phase synthesis of polymers using polymer substrates and systems for facilitating such methods allow gating of a synthetic reaction into a binary (reacted or unreacted) readout. Polymer substrates are used as carriers for molecular reagents and act as separation tags that allow them to be purified using nanoscale deterministic lateral displacement. Two polymer substrates are linked together by a bond-forming reaction to form a longer polymer that includes a synthetic product. The synthetic product can be purified away from unreacted polymers/reagents using strand-length dependent lateral displacement.

公开(公告)号：GB2583301B

公开(公告)日：2022-11-16

申请号：GB202010161

申请日：2019-01-14

Applicant: IBM

Inventor： BENJAMIN HARDY WUNSCH ,  JOSHUA THOMAS SMITH ,  SUNG-CHEOL KIM ,  STACEY GIFFORD

IPC: H01L23/427

Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx/Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.

公开(公告)号：GB2583301A

公开(公告)日：2020-10-21

申请号：GB202010161

申请日：2019-01-14

Applicant: IBM

Inventor： BENJAMIN HARDY WUNSCH ,  JOSHUA THOMAS SMITH ,  SUNG-CHEOL KIM ,  STACEY GIFFORD

IPC: H01L23/427

Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx /Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.