公开(公告)号：GB2553674B

公开(公告)日：2021-03-17

申请号：GB201713658

申请日：2016-02-12

Applicant: IBM

Inventor： JULIEN AUTEBERT ,  EMMANUEL DELAMARCHE ,  GOVIND KAIGALA ,  XANDER FRANK VAN KOOTEN

IPC: B01L3/00 ,  B01L3/02 ,  G01N35/08

Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.

公开(公告)号：GB2553675A

公开(公告)日：2018-03-14

申请号：GB201713688

申请日：2016-02-12

Applicant: IBM

Inventor： JULIEN AUTEBERT ,  EMMANUEL DELAMARCHE ,  GOVIND KAIGALA ,  ADITYA KASHYAP ,  XANDER FRANK VAN KOOTEN

IPC: B01L3/00 ,  B01L3/02 ,  G01N35/08

Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes comprising a respective target substance associated with a respective target area, the microfluidic probe head comprising: an inlet and an outlet, a first fluid channel fluidly connected to the inlet, the first fluid channel being configured for delivering an injection liquid from the inlet to a respective target area, the respective target area being covered by an immersion liquid and comprising a respective target substance, a second fluid channel fluidly connected to the outlet, the second fluid channel being configured for delivering liquid volumes from the respective target area to the outlet, each liquid volume including at least some of the injection liquid, at least some of the immersion liquid and a respective target substance, and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit being configured for inserting spacers into the second fluid channel between the liquid volumes to thereby provide the sequence of separate liquid volumes separated by spacers.

公开(公告)号：GB2553674A

公开(公告)日：2018-03-14

申请号：GB201713658

申请日：2016-02-12

Applicant: IBM

Inventor： JULIEN AUTEBERT ,  EMMANUEL DELAMARCHE ,  GOVIND KAIGALA ,  XANDER FRANK VAN KOOTEN

IPC: B01L3/02 ,  B01L3/00 ,  G01N35/08

Abstract: A microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers, the microfluidic probe head comprising: an inlet and an outlet, a first fluid channel and a second fluid channel, and a fluid bypass connecting the first fluid channel and the second fluid channel to each other, wherein, the first fluid channel is configured for delivering the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass connects the first fluid channel and the second fluid channel, to allow the spacers to be removed from the first fluid channel and thereby obtain a free sequence of separate liquid volumes, without spacers, the first fluid channel is configured for delivering the free sequence of separate liquid volumes to the deposition area, and the second fluid channel is configured for delivering the removed spacers from the fluid bypass to the outlet.