公开(公告)号：WO2015066006A3

公开(公告)日：2015-06-25

申请号：PCT/US2014062624

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: G01N15/02

CPC classification number: G01N15/14 ,  B01L3/502 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2400/086 ,  C12Q1/06 ,  G01N33/493 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2333/195

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

Abstract translation: 用于检测细菌并确定其在液体样品中的浓度的方法包括以下步骤：将光学部分穿过保持液体样品体积的容器在预定视场和预定焦平面深度或角度处，并且在 一段时间已经过去，以使样品中的非细菌沉淀到容器的底部。 由于细菌自动排列在液体样品中，形成格子状格栅图案，所以可以使用通过自动排列的细菌体积的光学部分来测量该部分中存在的细菌的数量。 用于保持液体样品的容器具有有助于将非细菌与细菌分离的特殊结构。

公开(公告)号：EP3063527A4

公开(公告)日：2017-10-18

申请号：EP14858727

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/06

CPC classification number: G01N15/14 ,  B01L3/502 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2400/086 ,  C12Q1/06 ,  G01N33/493 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2333/195

公开(公告)号：AU2019243592A1

公开(公告)日：2020-08-20

申请号：AU2019243592

申请日：2019-03-29

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  BUTCHER TIMOTHY ,  LIN JUI MING ,  RUSSELL JAMES

IPC: G16H40/40

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

公开(公告)号：AU2014342581B2

公开(公告)日：2020-01-16

申请号：AU2014342581

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: C12Q1/06 ,  B01L3/00 ,  G01N15/02

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

公开(公告)号：AU2014342581A1

公开(公告)日：2016-06-16

申请号：AU2014342581

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: C12Q1/06 ,  B01L3/00 ,  G01N15/02

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

公开(公告)号：AT546722T

公开(公告)日：2012-03-15

申请号：AT01937695

申请日：2001-05-24

Applicant: IDEXX LAB INC

Inventor： ROCHE JOHN ,  HANSEN W ,  JULIAN MARCUS ,  FLYNN HAROLD ,  RUSSELL JAMES ,  COLEMAN MICHELLE ,  CREWS HAROLD

IPC: G01N15/14 ,  G01N33/48 ,  B01L3/14 ,  G01N1/10 ,  G01N21/05 ,  G01N21/53 ,  G01N33/49 ,  G01N33/72 ,  H04L25/06

Abstract: The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.

公开(公告)号：CA2928829C

公开(公告)日：2021-10-26

申请号：CA2928829

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: C12Q1/06 ,  B01L3/00

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

公开(公告)号：CA3095020A1

公开(公告)日：2019-10-03

申请号：CA3095020

申请日：2019-03-29

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  BUTCHER TIMOTHY ,  LIN JUI MING ,  RUSSELL JAMES

IPC: G16H40/40

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

公开(公告)号：CA2928829A1

公开(公告)日：2015-05-07

申请号：CA2928829

申请日：2014-10-28

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  RUSSELL JAMES

IPC: C12Q1/06 ,  B01L3/00

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

公开(公告)号：AU2019243592B2

公开(公告)日：2022-07-07

申请号：AU2019243592

申请日：2019-03-29

Applicant: IDEXX LAB INC

Inventor： HAMMOND JEREMY ,  BUTCHER TIMOTHY ,  LIN JUI MING ,  RUSSELL JAMES

IPC: G16H40/40

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.