公开(公告)号：EP0804932B1

公开(公告)日：2001-05-16

申请号：EP97201854.3

申请日：1992-03-18

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C.

IPC: C08F20/06 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  A61K49/04 ,  A61K49/00 ,  G01R33/28 ,  A61K51/12

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

公开(公告)号：EP1535575A1

公开(公告)日：2005-06-01

申请号：EP04078475.3

申请日：1999-05-07

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C. ,  Wu, Yungui

IPC: A61B8/00 ,  G01S15/02 ,  G01N29/00 ,  H04N5/30 ,  G01N29/04

CPC classification number: A61B5/0091 ,  A61B5/0095 ,  A61B5/4312 ,  A61B8/0825 ,  A61B8/0833 ,  A61B8/5238 ,  G01S7/52074 ,  G01S15/8918 ,  G01S15/8922 ,  G01S17/89

Abstract: An optoacoustic system comprises an optoacoustic transducer including a first array of acoustic transducers and a second array of optical fibers; an acoustic subsystem for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.

Abstract translation: 光声系统包括光声换能器，其包括第一阵列的声换能器和第二阵列的光纤; 声学子系统，用于可控地激励声换能器的至少第一子集以产生具有规定脉冲宽度的声脉冲，以及用于基于从患者反射的返回声脉冲形成第一图像; 光学子系统，用于可控地产生要经由光纤的至少第一子集向患者透射的光脉冲，以及基于从患者反射的光形成第二图像; 以及用于使第一和第二图像相关联的图像相关装置。 第一和第二阵列可以采取各种形式，包括环形阵列的形式，其中声换能器同轴布置，并且光​​纤围绕第一阵列的外周设置。 第一和第二阵列也可以采取线性阵列的形式。

公开(公告)号：EP1064953A3

公开(公告)日：2002-07-03

申请号：EP00203214.2

申请日：1992-03-18

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C.

IPC: A61K9/50 ,  A61K49/22 ,  A61K47/48 ,  A61P9/00

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

Abstract: The invention provides contrast media for diagnostic imaging comprising a substantially homogeneous aqueous suspension of gas-filled microspheres, wherein the microspheres are filled with a perfluorocarbon gas. The microspheres are preferably formed from biocompatible synthetic polymers or copolymers.

公开(公告)号：EP0580726B1

公开(公告)日：1999-06-02

申请号：EP92910021.2

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C.

IPC: C08F20/06 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  A61K49/04 ,  A61K49/00 ,  G01R33/28 ,  A61K51/00

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

公开(公告)号：EP1593395A3

公开(公告)日：2005-11-16

申请号：EP05075094.2

申请日：1995-03-10

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C.

IPC: A61K49/00 ,  A61K9/127

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K9/5015 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1806 ,  A61K49/1815 ,  A61K49/1818 ,  A61K49/1821 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  G01R33/5601

Abstract: Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided. The microspheres contain at least one biocompatible lipid selected from the group consisting of dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine and dipalmitoylphosphatidic acid and a contrast agent selected from the group of paramagnetic and superparamagnetic agents.

公开(公告)号：EP0660714B1

公开(公告)日：2003-07-02

申请号：EP92912662.1

申请日：1992-03-31

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C. ,  Wu, Guanli

IPC: A61K9/127

CPC classification number: A61K9/1278 ,  A61K9/127 ,  A61K9/1277 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227

Abstract: Drug delivery systems comprising gas filled liposomes prepared using vacuum drying gas instillation methods and having encapsulated therein a drug, and gas filled liposomes substantially devoid of liquid in the interior thereof and having encapsulated therein a drug, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.

公开(公告)号：EP1252885A2

公开(公告)日：2002-10-30

申请号：EP02078168.8

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C. ,  Ramaswami, Varada Rajan ,  Fritz, Thomas A. ,  Yellowhair, David ,  Matsunaga, Terry ,  Wu, Guanli

IPC: A61K9/127 ,  A61K49/22

CPC classification number: A61K49/227 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61M5/3145 ,  Y10S424/812 ,  Y10S436/829 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/927 ,  Y10S977/929

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

Abstract translation: 描述了制备温度活化气态前体填充脂质体的方法和装置。 通过这些方法制备的气态前体填充的脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。

公开(公告)号：EP0804932A2

公开(公告)日：1997-11-05

申请号：EP97201854.3

申请日：1992-03-18

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C.

IPC: A61K49/00

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

Abstract: The invention provides contrast media for diagnostic imaging comprising a substantially homogeneous aqueous suspension of gas-filled microspheres, wherein the microspheres are filled with a perfluorocarbon gas. The microspheres are preferably formed from biocompatible synthetic polymers or copolymers.

Abstract translation: 本发明提供用于诊断成像的造影剂，其包括充气微球的基本均匀的水性悬浮液，其中所述微球充满全氟化碳气体。 微球优选由生物相容的合成聚合物或共聚物形成。

公开(公告)号：EP1588699A2

公开(公告)日：2005-10-26

申请号：EP04076135.5

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C. ,  Matsunaga, Terry O. ,  Yellowhair, David

IPC: A61K9/127 ,  A61K49/00

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

Abstract translation: 公开了一种容器，其包含水性脂质悬浮液和基本上与水稳定相分离的气相，其可用于诸如超声和磁共振成像以及治疗应用的诊断成像。

公开(公告)号：EP1046394A3

公开(公告)日：2001-10-10

申请号：EP00303249.7

申请日：2000-04-18

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C. ,  McCreery, Thomas ,  Sadewasser, David A.

IPC: A61K9/127 ,  A61K48/00 ,  C12N15/88

CPC classification number: A61K9/1272 ,  A61K9/1271

Abstract: The present invention is directed, inter alia , to compositions and their use for delivering compounds into a cell. In a preferred embodiment, the compositions comprise, in combination with the compound to be delivered, an organic halide, a targeting ligand, and a nuclear localization sequence, optionally in the presence of a carrier. Ultrasound may be applied, if desired. The compositions are particularly suitable for the treatment of inflammatory diseases.