公开(公告)号：WO2014116767A3

公开(公告)日：2014-07-31

申请号：PCT/US2014/012636

申请日：2014-01-23

Applicant: IMRA AMERICA, INC.

Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius ,  ITO, Masayuki ,  QIAN, Wei

IPC: B01J13/00

Abstract: The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.

公开(公告)号：WO2014178935A1

公开(公告)日：2014-11-06

申请号：PCT/US2014/016348

申请日：2014-02-14

Applicant: IMRA AMERICA, INC.

Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius

IPC: B01J13/00 ,  B82Y5/00 ,  G01N21/65

CPC classification number: G01N21/65 ,  B01J13/0043 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/658 ,  G01N2021/653

Abstract: Disclosed is a method for making a colloidal suspension of precious metal nanoparticles. The method comprises providing a target material comprising a precious metal in a liquid dispersion medium in an ablation container. The dispersion medium has an electrical conductivity within a predetermined conductivity range. Laser pulses are used to generate the nanoparticles from the target in the container. While generating the nanoparticles the electrical conductivity of the dispersion medium is monitored and maintained within the predetermined range and thereby the generated nanoparticles are produced within a predetermined size range. The generated nanoparticles are used to form a colloidal suspension.

Abstract translation: 公开了一种制备贵金属纳米颗粒的胶体悬浮液的方法。 该方法包括在消融容器中的液体分散介质中提供包含贵金属的靶材料。 分散介质具有预定电导率范围内的导电性。 激光脉冲用于从容器中的靶产生纳米颗粒。 在产生纳米颗粒的同时，监测分散介质的导电性并将其保持在预定范围内，从而在预定尺寸范围内产生生成的纳米颗粒。 生成的纳米粒子用于形成胶体悬浮液。

公开(公告)号：WO2013122988A1

公开(公告)日：2013-08-22

申请号：PCT/US2013/025845

申请日：2013-02-13

Applicant: IMRA AMERICA, INC.

Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius

IPC: A61K9/14

CPC classification number: A61K41/00 ,  A61J3/02 ,  A61K9/50 ,  A61K9/51 ,  Y10T428/2982

Abstract: The present disclosure is directed to an in-liquid laser-based method for fabricating a solution of fine particles of amorphous solid medicinal compounds, a solution of fine particles of amorphous medicinal agents made with the method, and fine particles made with the method. By using a target solidified via a phase transition process to covert an initial crystalline structure into an amorphous solid, technical difficulties with handling a hydraulically-pressed target are overcome. The laser-based ablation process produces amorphous solid medicinal compound fine particles, which improves the bioavailability and solubility of the medicinal compound. The improvement results from a combination of: disordered crystalline structure and enlarged relative surface area by particle size reduction. The laser based method may be carried out with ultrashort pulsed laser systems, or with UV nanosecond lasers. Results obtained with an ultrashort near IR laser and a UV nanosecond laser show formation of amorphous solid curcumin fine particles.

Abstract translation: 本公开涉及一种用于制造无定形固体药物化合物的微粒溶液的液体内基于激光的方法，用该方法制备的非晶医药的微粒溶液以及用该方法制成的微粒。 通过使用通过相变过程固化的靶将初始晶体结构转变为无定形固体，克服了处理液压压制靶的技术困难。 基于激光的消融过程产生无定形固体药物复合细颗粒，提高了药用化合物的生物利用度和溶解度。 通过以下组合的改进结果：无序的结晶结构和通过粒径减小扩大的相对表面积。 基于激光的方法可以用超短脉冲激光系统或UV纳秒激光器进行。 用超短距离近红外激光和UV纳秒激光显示的结果显示无定形固体姜黄素细颗粒的形成。