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    A METHOD AND APPARATUS TO PREPARE A SUBSTRATE FOR MOLECULAR DETECTION
    1.
    发明申请
    A METHOD AND APPARATUS TO PREPARE A SUBSTRATE FOR MOLECULAR DETECTION 审中-公开
    制备用于分子检测的底物的方法和装置

    公开(公告)号：WO2011100153A1

    公开(公告)日：2011-08-18

    申请号：PCT/US2011/023529

    申请日：2011-02-03

    Applicant: IMRA AMERICA, INC. ,  MURAKAMI, Makoto ,  CHE, Yong ,  LIU, Bing ,  ICHIKAWA, Yuki

    Inventor： MURAKAMI, Makoto ,  CHE, Yong ,  LIU, Bing ,  ICHIKAWA, Yuki

    IPC: G01J3/44 ,  B32B3/10

    CPC classification number: G01N21/658 ,  B82Y30/00 ,  B82Y40/00 ,  C23C14/083 ,  C23C14/3435

    Abstract: An device for Raman spectroscopy such as surface enhanced Raman spectroscopy (SERS) is disclosed herein. Various embodiments may be utilized to prepare a SERS substrate using several deposition techniques such as pulsed laser deposition. Some embodiments optimize coverage, volume, or elements of SERS active metals. The method is a single step inexpensive method for preparing a SERS active substrate. In some embodiments a coating layer underneath the SERS active metals is utilized for additional enhancements.

    Abstract translation: 本文公开了一种用于拉曼光谱的装置，例如表面增强拉曼光谱（SERS）。 可以使用多种沉积技术例如脉冲激光沉积来制备SERS衬底的各种实施例。 一些实施例优化SERS活性金属的覆盖，体积或元素。 该方法是用于制备SERS活性基底的单步廉价方法。 在一些实施方案中，SERS活性金属下面的涂层用于额外的增强。

    METHODS FOR PREPARING AQUEOUS SUSPENSION OF PRECIOUS METAL NANOPARTICLES
    2.
    发明申请
    METHODS FOR PREPARING AQUEOUS SUSPENSION OF PRECIOUS METAL NANOPARTICLES 审中-公开

    公开(公告)号：WO2014116767A3

    公开(公告)日：2014-07-31

    申请号：PCT/US2014/012636

    申请日：2014-01-23

    Applicant: IMRA AMERICA, INC.

    Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius ,  ITO, Masayuki ,  QIAN, Wei

    IPC: B01J13/00

    Abstract: The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.

    PULSED LASER PROCESSING METHOD PRODUCING SUPERHYDROPHOBIC SURFACES
    3.
    发明申请
    PULSED LASER PROCESSING METHOD PRODUCING SUPERHYDROPHOBIC SURFACES 审中-公开
    脉冲激光加工方法生产超级表面

    公开(公告)号：WO2014066138A1

    公开(公告)日：2014-05-01

    申请号：PCT/US2013/065456

    申请日：2013-10-17

    Applicant: IMRA AMERICA, INC.

    Inventor： LIU, Bing ,  ICHIKAWA, Yuki

    IPC: C21D1/09 ,  B05D3/00

    CPC classification number: B23K26/0084 ,  B05D3/06 ,  B05D5/08 ,  B05D5/083 ,  B05D2451/00 ,  B23K26/009 ,  C21D1/09 ,  C21D10/00 ,  C21D2201/00 ,  Y10T428/24355 ,  B05D2401/32 ,  B05D2401/40

    Abstract: A method of pulsed laser processing of solid surface for enhancing surface hydrophobicity is disclosed wherein the solid surface is covered with a transparent medium during laser processing and the laser beam incidents through the covering medium and irradiates the solid surface. Two effects are obtained simultaneously. One is the laser-induced texture formation directly under the laser irradiation. The other is the deposition of the laser-removed materials along the laser scan lines. Both effects introduce surface roughness on nanometer scales, and both enhance surface hydrophobicity, rendering superhydrophobicity on the surfaces of both the laser-irradiated solid and the covering medium. Because the beam scan line spacing can be larger than a single scan line width by multiple times, this method provides a high processing speed of square inch per minute and enables large area processing.

    Abstract translation: 公开了一种用于提高表面疏水性的固体表面的脉冲激光加工方法，其中固体表面在激光加工期间被透明介质覆盖，并且激光束通过覆盖介质入射并照射固体表面。 同时获得两个效果。 一种是直接在激光照射下的激光诱导纹理形成。 另一种是激光去除材料沿着激光扫描线的沉积。 这两种效应都会在纳米尺度上引入表面粗糙度，同时增强表面疏水性，从而在激光照射的固体和覆盖介质的表面上产生超疏水性。 由于光束扫描线间距可以大于单个扫描线宽度多次，因此该方法提供了高达每分钟平方英寸的处理速度，可实现大面积处理。

    SIZE CONTROLLED SUSPENSION OF PRECIOUS METAL NANOPARTICLES
    4.
    发明申请
    SIZE CONTROLLED SUSPENSION OF PRECIOUS METAL NANOPARTICLES 审中-公开
    尺寸控制悬浮的金属纳米材料

    公开(公告)号：WO2014178935A1

    公开(公告)日：2014-11-06

    申请号：PCT/US2014/016348

    申请日：2014-02-14

    Applicant: IMRA AMERICA, INC.

    Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius

    IPC: B01J13/00 ,  B82Y5/00 ,  G01N21/65

    CPC classification number: G01N21/65 ,  B01J13/0043 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/658 ,  G01N2021/653

    Abstract: Disclosed is a method for making a colloidal suspension of precious metal nanoparticles. The method comprises providing a target material comprising a precious metal in a liquid dispersion medium in an ablation container. The dispersion medium has an electrical conductivity within a predetermined conductivity range. Laser pulses are used to generate the nanoparticles from the target in the container. While generating the nanoparticles the electrical conductivity of the dispersion medium is monitored and maintained within the predetermined range and thereby the generated nanoparticles are produced within a predetermined size range. The generated nanoparticles are used to form a colloidal suspension.

    Abstract translation: 公开了一种制备贵金属纳米颗粒的胶体悬浮液的方法。 该方法包括在消融容器中的液体分散介质中提供包含贵金属的靶材料。 分散介质具有预定电导率范围内的导电性。 激光脉冲用于从容器中的靶产生纳米颗粒。 在产生纳米颗粒的同时，监测分散介质的导电性并将其保持在预定范围内，从而在预定尺寸范围内产生生成的纳米颗粒。 生成的纳米粒子用于形成胶体悬浮液。

    AMORPHOUS MEDICINAL FINE PARTICLES PRODUCED BY PULSED LASER ABLATION IN LIQUID AND THE PRODUCTION METHOD THEREOF
    5.
    发明申请
    AMORPHOUS MEDICINAL FINE PARTICLES PRODUCED BY PULSED LASER ABLATION IN LIQUID AND THE PRODUCTION METHOD THEREOF 审中-公开
    通过脉冲激光在液体中产生的非晶药物微粒及其生产方法

    公开(公告)号：WO2013122988A1

    公开(公告)日：2013-08-22

    申请号：PCT/US2013/025845

    申请日：2013-02-13

    Applicant: IMRA AMERICA, INC.

    Inventor： ICHIKAWA, Yuki ,  MARCINKEVICUS, Andrius

    IPC: A61K9/14

    CPC classification number: A61K41/00 ,  A61J3/02 ,  A61K9/50 ,  A61K9/51 ,  Y10T428/2982

    Abstract: The present disclosure is directed to an in-liquid laser-based method for fabricating a solution of fine particles of amorphous solid medicinal compounds, a solution of fine particles of amorphous medicinal agents made with the method, and fine particles made with the method. By using a target solidified via a phase transition process to covert an initial crystalline structure into an amorphous solid, technical difficulties with handling a hydraulically-pressed target are overcome. The laser-based ablation process produces amorphous solid medicinal compound fine particles, which improves the bioavailability and solubility of the medicinal compound. The improvement results from a combination of: disordered crystalline structure and enlarged relative surface area by particle size reduction. The laser based method may be carried out with ultrashort pulsed laser systems, or with UV nanosecond lasers. Results obtained with an ultrashort near IR laser and a UV nanosecond laser show formation of amorphous solid curcumin fine particles.

    Abstract translation: 本公开涉及一种用于制造无定形固体药物化合物的微粒溶液的液体内基于激光的方法，用该方法制备的非晶医药的微粒溶液以及用该方法制成的微粒。 通过使用通过相变过程固化的靶将初始晶体结构转变为无定形固体，克服了处理液压压制靶的技术困难。 基于激光的消融过程产生无定形固体药物复合细颗粒，提高了药用化合物的生物利用度和溶解度。 通过以下组合的改进结果：无序的结晶结构和通过粒径减小扩大的相对表面积。 基于激光的方法可以用超短脉冲激光系统或UV纳秒激光器进行。 用超短距离近红外激光和UV纳秒激光显示的结果显示无定形固体姜黄素细颗粒的形成。

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