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公开(公告)号：WO2005069971B1
公开(公告)日：2007-02-01
申请号：PCT/US2005002087
申请日：2005-01-24
Applicant: INCOM INC , MINOT MICHAEL J , DETARANDO MICHAEL A , KASS JASON
Inventor： MINOT MICHAEL J , DETARANDO MICHAEL A , KASS JASON
CPC classification number: G02B6/08 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L2200/12 , B01L2300/02 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , G01N21/03 , G01N21/253 , G01N2021/0346 , G01N2201/0833
Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.
Abstract translation: 本发明提供了可用于多个样品的光纤询问的微流体装置。 该装置包括整体地包括多个光纤的基板。 形成在衬底的表面上的层限定了与至少一个光纤通信的至少一个拓扑特征，用于询问样品。 该装置优选地包括多个拓扑特征，其可以包括井的图案化阵列，通道或其任何组合。 本发明的装置的多个光纤能够同时询问数千个样品。 这些样品可以包括但不限于分子，细胞，蛋白质组学，基因组或气体材料或测定。 本发明还公开了一种用于制造微流体装置的方法。 本发明还包括通过本文提供的微流体装置并行询问多个样品的方法。
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公开(公告)号：WO2005069971A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002087
申请日：2005-01-24
Applicant: INCOM INC , MINOT MICHAEL J , DETARANDO MICHAEL A , KASS JASON
Inventor： MINOT MICHAEL J , DETARANDO MICHAEL A , KASS JASON
CPC classification number: G02B6/08 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L2200/12 , B01L2300/02 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , G01N21/03 , G01N21/253 , G01N2021/0346 , G01N2201/0833
Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.
Abstract translation: 本发明提供了可用于多个样品的光纤询问的微流体装置。 该装置包括整体地包括多个光纤的基板。 形成在衬底的表面上的层限定了与至少一个光纤通信的至少一个拓扑特征，用于询问样品。 该装置优选地包括多个拓扑特征，其可以包括井的图案化阵列，通道或其任何组合。 本发明的装置的多个光纤能够同时询问数千个样品。 这些样品可以包括但不限于分子，细胞，蛋白质组学，基因组或气体材料或测定。 本发明还公开了一种用于制造微流体装置的方法。 本发明还包括通过本文提供的微流体装置并行询问多个样品的方法。
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公开(公告)号：CA2554126A1
公开(公告)日：2005-08-04
申请号：CA2554126
申请日：2005-01-24
Applicant: INCOM INC
Inventor： MINOT MICHAEL J , KASS JASON , DETARANDO MICHAEL A
Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. Th e device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. Th e plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include , without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.
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公开(公告)号：EP1733265A4
公开(公告)日：2009-06-24
申请号：EP05711851
申请日：2005-01-24
Applicant: INCOM INC
Inventor： MINOT MICHAEL J , DETARANDO MICHAEL A , KASS JASON
CPC classification number: G02B6/08 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L2200/12 , B01L2300/02 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , G01N21/03 , G01N21/253 , G01N2021/0346 , G01N2201/0833
Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.
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