公开(公告)号：WO2005069971B1

公开(公告)日：2007-02-01

申请号：PCT/US2005002087

申请日：2005-01-24

Applicant: INCOM INC ,  MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

Inventor： MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

IPC: G02B6/26 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G02B6/08

CPC classification number: G02B6/08 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  G01N21/03 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2201/0833

Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

Abstract translation: 本发明提供了可用于多个样品的光纤询问的微流体装置。 该装置包括整体地包括多个光纤的基板。 形成在衬底的表面上的层限定了与至少一个光纤通信的至少一个拓扑特征，用于询问样品。 该装置优选地包括多个拓扑特征，其可以包括井的图案化阵列，通道或其任何组合。 本发明的装置的多个光纤能够同时询问数千个样品。 这些样品可以包括但不限于分子，细胞，蛋白质组学，基因组或气体材料或测定。 本发明还公开了一种用于制造微流体装置的方法。 本发明还包括通过本文提供的微流体装置并行询问多个样品的方法。

公开(公告)号：WO2007056490A2

公开(公告)日：2007-05-18

申请号：PCT/US2006043571

申请日：2006-11-08

Applicant: INCOM INC ,  MINOT MICHAEL J ,  STOWE DAVID W

Inventor： MINOT MICHAEL J ,  STOWE DAVID W

IPC: C12M3/00

CPC classification number: G02B21/34 ,  G02B6/06

Abstract: The present invention provides a substrate that overcomes the performance limitations of conventional microscope slides, microarrays, or microtiter plates when optically interrogated through the thickness of the substrate. With conventional microscope slides, image quality and resolution are degraded as a result of distortions introduced by imaging through the thickness of the glass. Fiber Optic Interrogated Microslides (FOI) consist of many fiber optics that have been fused together. When sliced and polished to form microscope slides, the fibers effectively transfer optical images from one surface of the microslide to the other. The finished microslide is the optical equivalent of a zero thickness window. The image of an object on the top surface is transferred to the bottom surface allowing it to be viewed without focusing through the thickness of the slide. In addition to providing improved image quality, FOI microslides allow objects to be directly imaged without complex and expensive focusing optics .

Abstract translation: 本发明提供了当通过基底的厚度进行光学询问时克服了常规显微镜载玻片，微阵列或微量滴定板的性能限制的基底。 使用传统的显微镜载玻片，由于通过玻璃的厚度成像引入的失真，图像质量和分辨率降低。 光纤询问微滑石（FOI）由许多融合在一起的光纤组成。 当切片和抛光以形成显微镜载玻片时，纤维有效地将光学图像从微滑块的一个表面传递到另一个表面。 完成的微滑坡是零厚度窗口的光学等效物。 上表面上的物体的图像被转移到底部表面，使得它能够被观察而不聚焦穿过滑块的厚度。 除了提供改进的图像质量之外，FOI微滑镜允许物体直接成像，而无需复杂且昂贵的聚焦光学元件。

公开(公告)号：WO2005069971A2

公开(公告)日：2005-08-04

申请号：PCT/US2005002087

申请日：2005-01-24

Applicant: INCOM INC ,  MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

Inventor： MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

IPC: B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G02B6/08

CPC classification number: G02B6/08 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  G01N21/03 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2201/0833

Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

Abstract translation: 本发明提供了可用于多个样品的光纤询问的微流体装置。 该装置包括整体地包括多个光纤的基板。 形成在衬底的表面上的层限定了与至少一个光纤通信的至少一个拓扑特征，用于询问样品。 该装置优选地包括多个拓扑特征，其可以包括井的图案化阵列，通道或其任何组合。 本发明的装置的多个光纤能够同时询问数千个样品。 这些样品可以包括但不限于分子，细胞，蛋白质组学，基因组或气体材料或测定。 本发明还公开了一种用于制造微流体装置的方法。 本发明还包括通过本文提供的微流体装置并行询问多个样品的方法。

公开(公告)号：CA2554126A1

公开(公告)日：2005-08-04

申请号：CA2554126

申请日：2005-01-24

Applicant: INCOM INC

Inventor： MINOT MICHAEL J ,  KASS JASON ,  DETARANDO MICHAEL A

IPC: G01N21/01 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G02B6/08 ,  G02B6/10

Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. Th e device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. Th e plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include , without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.

公开(公告)号：EP1733265A4

公开(公告)日：2009-06-24

申请号：EP05711851

申请日：2005-01-24

Applicant: INCOM INC

Inventor： MINOT MICHAEL J ,  DETARANDO MICHAEL A ,  KASS JASON

IPC: G02B6/26 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G02B6/08

CPC classification number: G02B6/08 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  G01N21/03 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2201/0833

Abstract: The present invention provides a microfluidic device that can be used for fiber optic interrogation of multiple samples. The device comprises a substrate integrally comprising a plurality of optic fibers. A layer formed on a surface of the substrate defines at least one topological feature that communicates with at least one optic fiber for interrogation of a sample. The device preferably comprises a plurality of topological features that may include a patterned array of wells, channels or any combinations thereof. The plurality of optic fibers of a device of the invention are capable of interrogating thousands of samples simultaneously. These samples may include, without limitation, molecular, cellular, proteomic, genomic or gaseous materials or assays. The present invention also discloses a method for fabricating a microfluidic device. The invention also comprises a method for interrogating multiple samples in parallel via the microfluidic devices provided herein.