公开(公告)号：US20210032621A1

公开(公告)日：2021-02-04

申请号：US16964277

申请日：2019-01-23

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Ka Yeong LIM ,  Beum-Chang KANG ,  Seuk Min RYU

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/90

Abstract: The present disclosure relates to: an extended guide RNA and a composition for base editing, comprising the same; and a method for base editing and a method for producing genetically modified animals or plants, both methods using the composition for base editing.

公开(公告)号：US20240294945A1

公开(公告)日：2024-09-05

申请号：US18025446

申请日：2021-09-17

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Sung lk CHO ,  Beum-Chang KANG ,  Seonghyun LEE ,  Hyunji LEE ,  Young Geun MOK ,  Ji Min LEE ,  Eugene CHUNG

IPC: C12N15/90 ,  A61K48/00 ,  C12N9/22 ,  C12N9/78 ,  C12N15/10 ,  C12N15/82

CPC classification number: C12N15/90 ,  A61K48/005 ,  C12N9/22 ,  C12N9/78 ,  C12N15/102 ,  C12N15/82

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.