公开(公告)号：US20230151343A1

公开(公告)日：2023-05-18

申请号：US17919588

申请日：2021-04-26

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Jaesuk LEE

IPC: C12N9/22

CPC classification number: C12N9/22

Abstract: The present invention relates to a Cas9 variant or a nucleic acid encoding the same, a composition for editing a genome using Cas9 or a Cas9 variant or a nucleic acid encoding the same, and a method of editing a genome using the composition. Specifically, the present invention relates to a composition for editing a genome with excellent efficiency while reducing unwanted insertions/deletions (indels) by using a prime editing nuclease or a variant thereof, for example, Cas9 or a Cas9 variant or a nucleic acid encoding the same, and a method of editing a genome using the composition.

公开(公告)号：US20240294945A1

公开(公告)日：2024-09-05

申请号：US18025446

申请日：2021-09-17

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Sung lk CHO ,  Beum-Chang KANG ,  Seonghyun LEE ,  Hyunji LEE ,  Young Geun MOK ,  Ji Min LEE ,  Eugene CHUNG

IPC: C12N15/90 ,  A61K48/00 ,  C12N9/22 ,  C12N9/78 ,  C12N15/10 ,  C12N15/82

CPC classification number: C12N15/90 ,  A61K48/005 ,  C12N9/22 ,  C12N9/78 ,  C12N15/102 ,  C12N15/82

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.