公开(公告)号：US20250011438A1

公开(公告)日：2025-01-09

申请号：US18667700

申请日：2024-05-17

Applicant: Institute for Basic Science

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61K31/713 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US20230272057A1

公开(公告)日：2023-08-31

申请号：US18045964

申请日：2022-10-12

Applicant: Institute for Basic Science ,  Korea Advanced Institute of Science and Technology

Inventor： Gou Young Koh ,  Jeomil Bae ,  Mi Jeong Kim ,  Jin-Sung Park ,  Su Jin Seo ,  Jaeryung Kim ,  Jang Ryul Park ,  Pilhan Kim ,  Wangyuhl Oh

IPC: C07K16/22 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/22 ,  A61P35/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

公开(公告)号：US11498962B2

公开(公告)日：2022-11-15

申请号：US16995707

申请日：2020-08-17

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gou Young Koh ,  Jeomil Bae ,  Mi Jeong Kim ,  Jin-Sung Park ,  Su Jin Seo ,  Jaeryung Kim ,  Jang Ryul Park ,  Pilhan Kim ,  Wangyuhl Oh

IPC: A61K39/395 ,  C07K16/22 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

公开(公告)号：US20210079083A1

公开(公告)日：2021-03-18

申请号：US16995707

申请日：2020-08-17

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gou Young Koh ,  Jeomil Bae ,  Mi Jeong Kim ,  Jin-Sung Park ,  Su Jin Seo ,  Jaeryung Kim ,  Jang Ryul Park ,  Pilhan Kim ,  Wangyuhl Oh

IPC: C07K16/22 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention provides an angiogenesis inhibitor and a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

公开(公告)号：US20240207362A1

公开(公告)日：2024-06-27

申请号：US18383601

申请日：2023-10-25

Applicant: Institute for Basic Science (IBS) ,  Korea Advanced Institute of Science & Technology

Inventor： Jin-Hui Yoon ,  Hokyung Jin ,  Ji Hoon Ahn ,  Seon Pyo Hong ,  Myung Jin Yang ,  Gou Young Koh

IPC: A61K38/18 ,  A61K45/06 ,  A61K48/00 ,  A61P43/00

CPC classification number: A61K38/1866 ,  A61K45/06 ,  A61K48/005 ,  A61P43/00

Abstract: Described herein is a method of preventing or treating a neurodegenerative disease including administering an agent to a person in which the agent causes increase in outflow of cerebrospinal fluid through nasopharyngeal lymphatic plexus (NPLP), or an agent that causes contraction and relaxation of the circular smooth muscles covering the deep cervical lymphatic vessels (dcLVs).

公开(公告)号：US12024562B2

公开(公告)日：2024-07-02

申请号：US17111413

申请日：2020-12-03

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K31/713 ,  A61K39/3955 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US20210179719A1

公开(公告)日：2021-06-17

申请号：US17111413

申请日：2020-12-03

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61P27/06 ,  A61K45/06 ,  A61K39/395

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US10745472B2

公开(公告)日：2020-08-18

申请号：US16473685

申请日：2017-12-19

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gou Young Koh ,  Jaeryung Kim ,  Do Young Park

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/22 ,  A61P27/02 ,  A61P27/06

Abstract: The present invention relates to a composition which is for preventing and treating eye diseases and comprises an anti-angiopoietin-2 (Ang2) antibody and, more specifically, to a novel use of an anti-Ang2 antibody as an agent for preventing or treating eye diseases, wherein the anti-Ang2 antibody is specifically coupled to Ang2, is coupled to a Tie2 receptor together with Ang2, and has improved affinity. The composition according to the present invention can be usefully used to develop a treatment agent for macular degeneration, diabetic retinopathy, and glaucoma.