公开(公告)号：EP0341793A2

公开(公告)日：1989-11-15

申请号：EP89201165.1

申请日：1989-05-08

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Belluati, Mario

IPC: G01N27/416

CPC classification number: G01N33/492 ,  G01N33/84

Abstract: The invention relates to the formulation of combined-composition electrolyte and pH buffers for use as standardization solutions in analyzers for clinical chemistry which simultaneously use more than one ion-selective electrode plus more than one standard solution.
Each ion is present in the standard solution in stoichiometric quantity such as to compensate the effect due to the incomplete dissociation of the salt used, and to obtain an activity coefficient and liquid junction potential such as to reduce the error generated by the use of standardization solutions which do not take account of these quantities.
Buffer solutions are described having a pH within the range of 6-8 and an electrolyte composition (Na⁺, K⁺, Ca⁺ and Cl⁻) which reflect the composition of the biological liquid to be analyzed, namely whole blood, plasma or serum, in equilibrium with different partial pressures of oxygen and CO₂.

Abstract translation: 本发明涉及组合电解质和pH缓冲剂的配制，用作临床化学分析仪中的标准化溶液，其同时使用多于一种的离子选择性电极加上多于一种的标准溶液。 每个离子以化学计量的量存在于标准溶液中，以补偿由于所使用的盐的不完全解离而产生的影响，并且获得活性系数和液体接合电位，以减少使用标准化溶液产生的误差 这些都不考虑这些数量。 描述了pH在6-8范围内的缓冲溶液和反映待分析的生物液体的组成的电解质组合物（Na +，K +，Ca +和Cl - ） ，即全血，血浆或血清，与氧气和二氧化碳的不同分压平衡。

公开(公告)号：EP0341793B1

公开(公告)日：1993-09-01

申请号：EP89201165.1

申请日：1989-05-08

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Belluati, Mario

IPC: G01N27/416

CPC classification number: G01N33/492 ,  G01N33/84

公开(公告)号：EP0341793A3

公开(公告)日：1990-09-12

申请号：EP89201165.1

申请日：1989-05-08

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Belluati, Mario

IPC: G01N27/416

CPC classification number: G01N33/492 ,  G01N33/84

Abstract: The invention relates to the formulation of combined-composition electrolyte and pH buffers for use as standardization solutions in analyzers for clinical chemistry which simultaneously use more than one ion-selective electrode plus more than one standard solution.
Each ion is present in the standard solution in stoichiometric quantity such as to compensate the effect due to the incomplete dissociation of the salt used, and to obtain an activity coefficient and liquid junction potential such as to reduce the error generated by the use of standardization solutions which do not take account of these quantities.
Buffer solutions are described having a pH within the range of 6-8 and an electrolyte composition (Na⁺, K⁺, Ca⁺ and Cl⁻) which reflect the composition of the biological liquid to be analyzed, namely whole blood, plasma or serum, in equilibrium with different partial pressures of oxygen and CO₂.