公开(公告)号：EP0299659A2

公开(公告)日：1989-01-18

申请号：EP88306086.5

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S.

IPC: G01N35/08 ,  G01N35/06 ,  G01N1/00

CPC classification number: G01N35/085 ,  G01N35/10 ,  G01N2035/00326

Abstract: An analysis system includes analysis station structure, sample station structure spaced from the analysis station structure along a straight line path, support shaft structure disposed along an axis parallel to the straight line path, and a transport carriage with probe structure mounted on the carriage. The transport carriage is mounted on the support shaft structure for movement along that shaft and is keyed thereto for pivoting movement in response to rotation of the shaft. A first drive includes a drive motor and cable structure coupled between the carriage and the drive motor for moving the transport carriage along the shaft to selectively position the probe structure at the sample and analysis stations, and a second drive rotates the shaft for inserting the probe into and withdrawing the probe from chamber structure at the sample and analysis stations. Metering means coupled to the probe flows liquid into and discharges liquid from the probe.

Abstract translation: 分析系统包括分析站结构，沿着直线路径与分析站结构隔开的采样站结构，沿着平行于直线路径的轴线设置的支撑轴结构，以及安装在滑架上的探针结构的运输托架。 运输托架安装在支撑轴结构上，用于沿着该轴移动，并且被连接到其上以响应于轴的旋转而枢转运动。 第一驱动器包括驱动马达和电缆结构，其联接在托架和驱动马达之间，用于沿着轴移动运输托架以选择性地将探针结构定位在样本和分析台处，并且第二驱动器使轴旋转以插入探针 从样品和分析台的室结构进入和取出探针。 耦合到探针的计量装置将液体流入并从探针排出液体。

公开(公告)号：EP0299661A2

公开(公告)日：1989-01-18

申请号：EP88306089.9

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S. ,  Rasmussen, James

IPC: G01N35/08

CPC classification number: G01N35/085

Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.

Abstract translation: 液体处理系统包括流网络模块结构，其限定流体通道阵列和用于控制通过流动通道阵列的液体流的多个阀。 流网络模块结构适于连接到外部源，用于向流动网络阵列施加压差以在阵列的通道内产生液体流。 还包括在流动网络模块中的腔室结构连接到流动通道阵列并且在模块结构的外表面中具有端口结构。 模块结构上的阀结构可在端口结构关闭的第一位置和端口结构打开的第二位置之间移动，该阀结构包括用于在第一位置和第二位置之间移动阀构件的致动器结构。 液体转移结构，包括运输结构上承载的输送结构和探针结构，适于引起阀结构从其第一位置到其第二位置的运动，同时探针结构的运动与腔室结构对准以进行输送 的一定量的样品材料到样品室，随后流过流动网络阵列以与辅助流体相互作用并在外部压力源的影响下转移到相关联的利用装置。

公开(公告)号：EP0299658A2

公开(公告)日：1989-01-18

申请号：EP88306085.7

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Qureshi, Humayun ,  Liffman, Stanley M. ,  Webster, Milo E. ,  Geiselman, Theodore S.

IPC: G01N35/08

CPC classification number: G01N35/085 ,  G01N1/14 ,  G01N35/1097 ,  G01N2001/382 ,  G01N2035/00237 ,  Y10T436/117497

Abstract: An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.

Abstract translation: 分析系统包括具有定义减压储存器的结构的样本插入模块结构，以及限定样本区域的结构，以及限定包括与试剂电路串联的计量室结构的试剂回路的结构。 第一转移阀结构被布置为将样品区域连接到计量室结构的一侧上的试剂回路，并且第二转移阀结构被布置成将试剂回路连接到计量室结构侧的减压储存结构 远离第一转移阀结构，用于将完整计量的样品液体插入到试剂流中。

公开(公告)号：EP0299661A3

公开(公告)日：1990-08-29

申请号：EP88306089.9

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S. ,  Rasmussen, James

IPC: G01N35/08

CPC classification number: G01N35/085

Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.

公开(公告)号：EP0299659A3

公开(公告)日：1990-08-22

申请号：EP88306086.5

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S.

IPC: G01N35/08 ,  G01N35/06 ,  G01N1/00

CPC classification number: G01N35/085 ,  G01N35/10 ,  G01N2035/00326

Abstract: An analysis system includes analysis station structure, sample station structure spaced from the analysis station structure along a straight line path, support shaft structure disposed along an axis parallel to the straight line path, and a transport carriage with probe structure mounted on the carriage. The transport carriage is mounted on the support shaft structure for movement along that shaft and is keyed thereto for pivoting movement in response to rotation of the shaft. A first drive includes a drive motor and cable structure coupled between the carriage and the drive motor for moving the transport carriage along the shaft to selectively position the probe structure at the sample and analysis stations, and a second drive rotates the shaft for inserting the probe into and withdrawing the probe from chamber structure at the sample and analysis stations. Metering means coupled to the probe flows liquid into and discharges liquid from the probe.

公开(公告)号：EP0299658A3

公开(公告)日：1990-05-16

申请号：EP88306085.7

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Qureshi, Humayun ,  Liffman, Stanley M. ,  Webster, Milo E. ,  Geiselman, Theodore S.

IPC: G01N35/08

CPC classification number: G01N35/085 ,  G01N1/14 ,  G01N35/1097 ,  G01N2001/382 ,  G01N2035/00237 ,  Y10T436/117497

Abstract: An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.