公开(公告)号：EP0184242B1

公开(公告)日：1993-05-05

申请号：EP85201845.6

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Preda, Luigi

IPC: G01N21/51 ,  G01N33/86 ,  G01N33/48 ,  G01N21/07 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N21/07 ,  G01N21/51 ,  G01N33/4905 ,  Y10S436/909 ,  Y10T436/111666 ,  Y10T436/25375

公开(公告)号：EP0184242A2

公开(公告)日：1986-06-11

申请号：EP85201845.6

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Preda, Luigi

IPC: G01N21/51 ,  G01N33/86 ,  G01N33/48 ,  G01N21/07 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N21/07 ,  G01N21/51 ,  G01N33/4905 ,  Y10S436/909 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: An instrument for measuring coagulation parameters is provided in which plasma and at least one reagent are mixed by spinning in a cuvette with transparent windows and in which measurement is then made of scatter by the mixture of the energy of a light beam sent into the mixture.
Upon spin, the plasma components and reagent are displaced into the chamber,thus determining the initiation of the presence of the mixture in which the clot forms, and a photodetecting unit senses the change in the energy of the scattered light, caused by clot formation.

公开(公告)号：EP1045250A1

公开(公告)日：2000-10-18

申请号：EP99830209.5

申请日：1999-04-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Preda, Luigi

IPC: G01N33/86 ,  C12Q1/56

CPC classification number: C12Q1/56 ,  G01N33/86 ,  G01N2333/974

Abstract: The present invention relates to an analytical test for evaluating the functionality of the thrombin/antithrombin system.
In particular, the present invention relates to an analytical method for evaluating the functionality of the thrombin/antithrombin system, comprising the following steps:

(a) mixing a sample of plasma to be analyzed with an agent promoting the inhibitory activity of antithrombin;
(b) adding a Factor II activating agent to the mixture produced in step (a);
(c) measuring the time ta taken to convert the fibrinogen of the mixture produced in step (b) into fibrin.

Abstract translation: 本发明涉及评价凝血酶/抗凝血酶系统功能的分析试验。 具体而言，本发明涉及评价凝血酶/抗凝血酶系统功能的分析方法，包括以下步骤：（a）将待分析血浆样品与促进抗凝血酶抑制活性的试剂混合; （b）在步骤（a）中制备的混合物中加入因子II活化剂; （c）测量将步骤（b）中制备的混合物的纤维蛋白原转化为纤维蛋白的时间。

公开(公告)号：EP0184242A3

公开(公告)日：1987-10-07

申请号：EP85201845

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Preda, Luigi

IPC: G01N21/51 ,  G01N33/86 ,  G01N33/48 ,  G01N21/07 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N21/07 ,  G01N21/51 ,  G01N33/4905 ,  Y10S436/909 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: An instrument for measuring coagulation parameters is provided in which plasma and at least one reagent are mixed by spinning in a cuvette with transparent windows and in which measurement is then made of scatter by the mixture of the energy of a light beam sent into the mixture. Upon spin, the plasma components and reagent are displaced into the chamber,thus determining the initiation of the presence of the mixture in which the clot forms, and a photodetecting unit senses the change in the energy of the scattered light, caused by clot formation.

公开(公告)号：EP0406971B1

公开(公告)日：1995-02-15

申请号：EP90201762.3

申请日：1990-07-02

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Preda, Luigi ,  Lombardi, Antonio

IPC: C12Q1/56 ,  G01N33/86

CPC classification number: G01N33/86 ,  C12Q1/56 ,  G01N2333/4626 ,  G01N2333/745 ,  G01N2333/96461 ,  Y10S435/975

公开(公告)号：EP0406971A1

公开(公告)日：1991-01-09

申请号：EP90201762.3

申请日：1990-07-02

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Preda, Luigi ,  Lombardi, Antonio

IPC: C12Q1/56 ,  G01N33/86

CPC classification number: G01N33/86 ,  C12Q1/56 ,  G01N2333/4626 ,  G01N2333/745 ,  G01N2333/96461 ,  Y10S435/975

Abstract: To determine the biological activity of protein S in a sample of human plasma, the suitably diluted sample is added to a substrate formed from plasma deficient in protein S, in which protein C is activated. The functionality of protein S is evaluated by a coagulometric test using bovine thromboplastin with added calcium as the phospholipid source.

Abstract translation: 为了确定人血浆样品中蛋白S的生物活性，将合适稀释的样品加入由蛋白质S激活的蛋白质S缺乏的血浆形成的底物中。 蛋白S的功能通过使用加入钙作为磷脂源的牛凝血激酶的凝血测定法进行评估。