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公开(公告)号：GB2423579A
公开(公告)日：2006-08-30
申请号：GB0609804
申请日：2004-10-18
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , GERTH CHRISTOPHER , YAMAKAWA MINEO
Abstract: The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte (210) such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel (185) and sample cell (175) that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
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2.发明申请A METHOD AND DEVICE FOR DETECTING A SMALL NUMBER OF MOLECULES USING SURFACE-ENHANCED COHERENT ANTI-STOKES RAMAN SPECTROSCOPY 审中-公开一种使用表面增强相干抗反射拉曼光谱检测小数量分子的方法和装置
公开(公告)号：WO2005040742A3
公开(公告)日：2007-04-26
申请号：PCT/US2004033054
申请日：2004-10-06
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , YAMAKAWA MINEO , GERTH CHRISTOPHER
CPC classification number: G01J3/44 , G01N21/658 , G01N2021/653 , G01N2021/656
Abstract: The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte 210 such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel 185 and sample cell 175 that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
Abstract translation: 本文公开的装置和方法涉及使用表面增强的相干反斯托克斯拉曼光谱法检测，鉴定和定量分析物，例如具有高分辨率和快速响应时间的核酸。 在本发明的某些实施方案中，分析物210（例如核苷酸）的少量分子样品通过含有拉曼活性表面的微流体通道，微通道或纳米通道185和样品池175，并且通过表面增强， 相干反斯托克斯拉曼光谱（SECARS）。 本发明的其它实施方案涉及用于分析物检测的装置。
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公开(公告)号：DE112004001972T5
公开(公告)日：2006-08-17
申请号：DE112004001972
申请日：2004-10-18
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , GERTH CHRISTOPHER , YAMAKAWA MINEO
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4.发明申请A METHOD AND DEVICE FOR DETECTING SMALL NUMBERS OF MOLECULES USING SURFACE-ENHANCED COHERENT ANTI-STOKES RAMAN SPECTROSCOPY 审中-公开一种利用表面增强相干抗反射拉曼光谱检测小分子数的方法和装置
公开(公告)号：WO2005038419A8
公开(公告)日：2005-06-30
申请号：PCT/US2004034598
申请日：2004-10-18
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , GERTH CHRISTOPHER , YAMAKAWA MINEO
CPC classification number: G01N21/658 , G01J3/44 , G01N2021/653
Abstract: The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte (210) such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel (185) and sample cell (175) that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
Abstract translation: 本文公开的装置和方法涉及使用表面增强的相干反斯托克斯拉曼光谱法检测，鉴定和定量分析物，例如具有高分辨率和快速响应时间的核酸。 在本发明的某些实施方案中，诸如核苷酸的分析物（210）的少量分子样品通过含有拉曼活性表面的微流体通道，微通道或纳米通道（185）和样品池（175），以及 通过表面增强，相干反斯托克斯拉曼光谱（SECARS）检测。 本发明的其它实施方案涉及用于分析物检测的装置。
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Patent Agency Ranking
公开(公告)号：GB2423579B
公开(公告)日：2008-04-09
申请号：GB0609804
申请日：2004-10-18
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , GERTH CHRISTOPHER , YAMAKAWA MINEO
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6.发明申请A METHOD AND DEVICE FOR DETECTING SMALL NUMBERS OF MOLECULES USING SURFACE-ENHANCED COHERENT ANTI-STOKES RAMAN SPECTROSCOPY 审中-公开使用表面增强的相干反驻波拉曼光谱检测分子小数的方法和装置
公开(公告)号：WO2005038419A3
公开(公告)日：2005-09-22
申请号：PCT/US2004034598
申请日：2004-10-18
Applicant: INTEL CORP
Inventor： KOO TAE-WOONG , GERTH CHRISTOPHER , YAMAKAWA MINEO
CPC classification number: G01N21/658 , G01J3/44 , G01N2021/653
Abstract: The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte (210) such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel (185) and sample cell (175) that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
Abstract translation: 本文公开的装置和方法涉及使用表面增强的相干反斯托克斯拉曼光谱以高分辨率和快速响应时间来检测，鉴定和或定量分析物例如核酸。 在本发明的某些实施方案中，分析物（210）的少量分子样品例如核苷酸穿过含有拉曼活性表面的微流体通道，微通道或纳米通道（185）和样品池（175），并且 通过表面增强的相干反斯托克斯拉曼光谱（SECARS）检测。 本发明的其他实施例涉及用于分析物检测的装置。
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公开(公告)号：WO2004031749A3
公开(公告)日：2004-06-24
申请号：PCT/US0330997
申请日：2003-09-30
Applicant: INTEL CORP
Inventor： BERLIN ANDREW , GERTH CHRISTOPHER , KOO TAE-WOONG
CPC classification number: G01N21/65 , G01N21/658 , G01N2021/052 , G01N2021/653 , G01N2021/655 , Y10T436/143333
Abstract: Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the spectroscopy. The chamber may have a resonant cavity to contain a sample for analysis, at least one window to the cavity to transmit the first radiation into the cavity and to transmit a second radiation out, a plurality of reflectors affixed to a housing of the cavity to reflect radiation of a predetermined frequency, the plurality of reflectors separated by a distance that is sufficient to resonate the radiation. The spectroscopic analysis system may be coupled with a nucleic acid sequencing system to receive a single nucleic acid derivative in solution and identify the derivative to sequence the nucleic acid.
Abstract translation: 公开了用于分析样品的光谱分析系统和方法。 分析系统可以包含用于提供辐射的电磁辐射源，用于执行相干拉曼光谱（例如，受激拉曼或相干反斯托克斯拉曼光谱）的光谱分析室，以及基于光谱检测辐射的辐射检测器。 腔室可以具有一个谐振腔，以容纳用于分析的样本，至少一个窗口，用于将腔室中的第一辐射传输到腔体中并传输第二辐射，多个反射器固定到空腔的壳体以反射 预定频率的辐射，多个反射器分开足以使辐射共振的距离。 光谱分析系统可以与核酸测序系统结合以在溶液中接受单个核酸衍生物，并鉴定衍生物以对核酸进行排序。
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公开(公告)号：AU2003282896A8
公开(公告)日：2004-04-23
申请号：AU2003282896
申请日：2003-09-30
Applicant: INTEL CORP
Inventor： GERTH CHRISTOPHER , KOO TAE-WOONG , BERLIN ANDREW
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公开(公告)号：AU2003282896A1
公开(公告)日：2004-04-23
申请号：AU2003282896
申请日：2003-09-30
Applicant: INTEL CORP
Inventor： BERLIN ANDREW , GERTH CHRISTOPHER , KOO TAE-WOONG
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