公开(公告)号：HK1084067A1

公开(公告)日：2006-07-21

申请号：HK06104176

申请日：2006-04-06

Applicant: INTEL CORP

Inventor： MINEO YAMAKAWA ,  JOHN HECK ,  SELENA CHAN ,  NARAYANAN SUNDARARAJAN

IPC: B01L20060101 ,  G01N33/483 ,  B01D63/08 ,  B01D71/02 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  B81C3/00 ,  B82B3/00 ,  G01N35/08 ,  G01N35/10 ,  G01N37/00

Abstract: Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In other aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic. Accordingly, the apparatus may further include instrumentation or detection equipment to measure the changes, such as optic-based detectors and electronic instrumentation.

公开(公告)号：MY134271A

公开(公告)日：2007-11-30

申请号：MYPI20032186

申请日：2003-06-12

Applicant: INTEL CORP

Inventor： SELENA CHAN ,  BERLIN ANDREW A ,  MINEO YAMAKAWA

IPC: G01J3/44 ,  C12Q1/68 ,  G01N21/65 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

Abstract: THE METHODS AND APPARATUS (300) DISCLOSED HEREIN CONCERN RAMAN SPECTROSCOPY USING METAL COATED NANOCRYSTALLINE POROUS SILICON SUBSTRATES (240, 340). IN CERTAIN EMBODIMENTS OF THE INVENTION, POROUS SILICON SUBSTRATES (110, 210) MAY BE FORMED BY ANODIC ETCHING IN DILUTE HYDROFLUORIC ACID (150).A THIN COATING OF A RAMAN ACTIVE METAL, SUCH AS GOLD OR SILVER, MAY BE COATED ONTO THE POROUS SILICON (110, 210) BY CATHODIC ELECTROMIGRATION OR ANY KNOWN TECHNIQUE. THE METAL-COATED SUBSTRATE (240, 340) PROVIDES AN EXTENSIVE, METAL RICH ENVIRONMENT FOR SERS, SERRS,HYPER- RAMAN AND/OR CARS RAMAN SPECTROSCOPY. IN CERTAIN EMBODIMENTS OF THE INVENTION, METAL NANOPARTICLES MAY BE ADDED TO THE METAL-COATED SUBSTRATE (240, 340) TO FURTHER ENHANCE THE RAMAN SIGNALS. RAMAN SPECTROSCOPY MAY BE USED TO DETECT, IDENTIFY AND/OR QUANTIFY A WIDE VARIETY OF ANALYTES, USING THE DISCLOSED METHODS AND APPARATUS (300).(FIG 2)

公开(公告)号：DE60316150D1

公开(公告)日：2007-10-18

申请号：DE60316150

申请日：2003-05-16

Applicant: INTEL CORP

Inventor： CHAN SELENA ,  BERLIN ANDREW ,  MINEO YAMAKAWA

IPC: G01J3/44 ,  C12Q1/68 ,  G01N21/65 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

Abstract: The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340 . In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150 . A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon 110, 210 by cathodic electromigration or any known technique. The metal-coated substrate 240, 340 provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain embodiments of the invention, metal nanoparticles may be added to the metal-coated substrate 240, 340 to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus 300.

公开(公告)号：MY136594A

公开(公告)日：2008-10-31

申请号：MYPI20033120

申请日：2003-08-15

Applicant: INTEL CORP

Inventor： SELENA CHAN ,  XING SU ,  MINEO YAMAKAWA

IPC: C12M1/34 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/543 ,  G01N33/573 ,  G01Q60/00 ,  G01Q70/12 ,  G01Q70/18 ,  G01Q80/00 ,  G06F19/00

Abstract: THE METHODS, APPARATUS AND COMPOSITIONS DISCLOSED HEREIN CONCERN THE DETECTION, IDENTIFIATION AND/OR SEQUENCING OF BIOMOLECULES, SUCH AS NUCLEIC ACIDS OR PROTEINS. IN CERTAIN EMBODIMENTS OF THE INVENTION, CODED PROBES COMPRISING A PROBE MOLECULE ATTACHED TO ONE OR MORE NANOBARCODES MAY BE ALLOWED TO BIND TO ONE OR MORE TARGET MOLECULES. AFTER BINDING AND SEPARATION FROM UNBOUND CODED PROBES, THE BOUND CODED PROBES MAY BE ALIGNED ONA SURFACE AND ANALYZED BY SCANNING PROBE MICROSCOPY. THE NANOBARCODES MAY BE ANY MOLECULE OR COMPLEX THAT IS DISTINGUISHABLE BY SPM, SUCH AS CARBON NANOTUBES , FULLERENESS, SUBMICROMETER METALLIC BARCODES, NANOPARTICLES OR QUANTUM DOTS. WHERE THE PROBES ARE OLIGONUCLEOTIDES,ADJACENT CODED PROBES HYBRIDIZED TO A TARGET NUCLEIC ACID MAY BE LIGATED TOGETHER BEFORE ALIGNMENT AN DSPM ANALYSIS. COMPOSITIONS COMPRISING CODED PROBES ARE ALSO DISCLOSED HEREIN. SYSTEMS FOR BIOMOLECULE ANALYSIS MAY COMPRISE AN SPM INSTRUMENT AND AT LEAST ONE CODED PROBE ATTACHED TO A SURFACE.

公开(公告)号：MY134398A

公开(公告)日：2007-12-31

申请号：MYPI20033401

申请日：2003-09-09

Applicant: INTEL CORP

Inventor： XING SU ,  SELENA CHAN ,  TAE-WOONG KOO ,  MINEO YAMAKAWA ,  BERLIN ANDREW A

IPC: G01N33/543 ,  C12Q1/68 ,  G01B7/34

Abstract: THE PRESENT METHODS AND APPARATUS CONCERN THE DETECTION AND/OR IDENTIFICATION OF TARGET ANALYTES USING PROBE MOLECULES. IN VARIOUS EMBODIMENTS OF THE INVENTION, THE PROBES OR ANALYTES ARE ATTACHED TO ONE OR MORE CANTILEVERS. BINDING OF A PROBE TO AN ANALYTE RESULTS IN DEFLECTION OF THE CANTILEVER, DETECTED BY A DETECTION UNIT. A COUNTERBALANCING FORCE MAY BE APPLIED TO RESTORE THE CANTILEVER TO ITS ORIGINAL POSITION. THE COUNTERBALANCING FORCE MAY BE MAGNETIC, ELECTRICAL OR RADIATIVE. THE DETECTION UNIT AND THE MECHANISM GENERATING THE COUNTERBALANCING FORCE MAY BE OPERABLY COUPLED TO AN INFORMATION PROCESSING AND CONTROL UNIT, SUCH AS A COMPUTER. THE COMPUTER MAY REGULATE A FEEDBACK LOOP THAT MAINTAINS THE CANTILEVER IN A FIXED POSITION BY BALANCING THE DEFLECTING FORCE AND THE COUNTERBALANCING FORCE. THE CONCENTRATION OF ANALYTES IN A SAMPLE MAY BE DETERMINED FROM THE MAGNITUDE OF THE COUNTERBALANCING FORCE REQUIRED TO MAINTAIN THE CANTILEVER IN A FIXED POSITION.(FIG 1)

公开(公告)号：MY139029A

公开(公告)日：2009-08-28

申请号：MYPI20033197

申请日：2003-08-22

Applicant: INTEL CORP

Inventor： SELENA CHAN ,  NARAYAN SUNDARARAJAN ,  BERLIN ANDREW A ,  MINEO YAMAKAWA

IPC: G01N37/00 ,  B01D61/02 ,  B01D61/14 ,  B01D61/18 ,  B01D61/20 ,  B01D69/02 ,  B01D71/02 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00

Abstract: MICROFLUIDIC DEVICE (100) WITH POROUS MEMBRANES FOR MOLECULAR SIEVING, METERING, AND SEPARATION OF ANALYTE FLUIDS. IN ONE ASPECT, A MICROFLUIDIC DEVICE INCLUDES A SUBSTRATE (106) HAVING INPUT AND OUTPUT MICROFLUIDIC CHANNEL SECTIONS (108, 112) SEPARATED BY A POROUS MEMBRANE (202) FORMED INTEGRAL TO THE SUBSTRATE. IN ANOTHER ASPECT, THE POROUS MEMBRANE MAY COMPRISE A THIN MEMBRANE THAT IS SANDWICHED BETWEEN UPPER AND LOWER SUBSTRATE MEMBERS (220, 222). THE MICROFLUIDIC DEVICE MAY INCLUDE ONE OR A PLURALITY OF POROUS MEMBRANES. IN ONE EMBODIMENT, A PLURALITY OF POROUS MEMBRANES (202) HAVING INCREASINGLY SMALLER PORES ARE DISPOSED ALONG PORTIONS OF A MICROFLUIDIC CHANNEL. IN ANOTHER EMBODIMENT, A CASCADING SERIES OF UPPER AND LOWER CHANNELS (204, 206) ARE EMPLOYED, WHEREIN EACH UPPER/LOWER CHANNEL INTERFACE IS SEPARATED BY A RESPECTIVE POROUS MEMBRANE. IN ANOTHER ASPECT, A POROUS MEMBRANE IS ROTATABLY COUPLED TO A SUBSTRATE WITHIN A MICROFLUIDIC CHANNEL VIA A MEMS ACTUATOR (642) TO ENABLE THE POROUS MEMBRANE TO BE POSITIONED IN FILTERING AND PASS-THROUGH POSITIONS.

公开(公告)号：DE60316150T2

公开(公告)日：2008-06-05

申请号：DE60316150

申请日：2003-05-16

Applicant: INTEL CORP

Inventor： CHAN SELENA ,  BERLIN ANDREW ,  MINEO YAMAKAWA

IPC: G01J3/44 ,  C12Q1/68 ,  G01N21/65 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

Abstract: The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340 . In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150 . A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon 110, 210 by cathodic electromigration or any known technique. The metal-coated substrate 240, 340 provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain embodiments of the invention, metal nanoparticles may be added to the metal-coated substrate 240, 340 to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus 300.

公开(公告)号：AT372505T

公开(公告)日：2007-09-15

申请号：AT03760213

申请日：2003-05-16

Applicant: INTEL CORP

Inventor： CHAN SELENA ,  BERLIN ANDREW ,  MINEO YAMAKAWA

IPC: G01J3/44 ,  C12Q1/68 ,  G01N21/65 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

Abstract: The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340 . In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150 . A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon 110, 210 by cathodic electromigration or any known technique. The metal-coated substrate 240, 340 provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain embodiments of the invention, metal nanoparticles may be added to the metal-coated substrate 240, 340 to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus 300.

公开(公告)号：AU2003232139A1

公开(公告)日：2003-12-31

申请号：AU2003232139

申请日：2003-05-16

Applicant: INTEL CORP

Inventor： CHAN SELENA ,  BERLIN ANDREW ,  MINEO YAMAKAWA

IPC: C12Q1/68 ,  G01J3/44 ,  G01N21/65 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

Abstract: The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340 . In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150 . A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon 110, 210 by cathodic electromigration or any known technique. The metal-coated substrate 240, 340 provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain embodiments of the invention, metal nanoparticles may be added to the metal-coated substrate 240, 340 to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus 300.