公开(公告)号：WO1997011738A1

公开(公告)日：1997-04-03

申请号：PCT/US1996015449

申请日：1996-09-26

Applicant: INTERVENTIONAL INNOVATIONS CORPORATION

Inventor： INTERVENTIONAL INNOVATIONS CORPORATION ,  CHORNENKY, Victor, I. ,  FORMAN, Michael, R.

IPC: A61M31/00

CPC classification number: A61M25/09 ,  A61M25/007 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0047 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/1052 ,  A61M2205/36

Abstract: Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter (110) with an occlusion balloon (114) for isolating the region proximal to the thrombus, a guide wire (200) with an occlusion balloon (202) for isolating the region distal to the thrombus, and an infusion catheter (300) for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen (122) of the guide catheter is preferably provided to evacuate material proximal to the thrombus. The lumen (122) can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body as well.

Abstract translation: 公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。 所述系统优选地包括导引导管（110），所述引导导管（110）具有用于隔离所述血栓附近的区域的阻塞气囊（114），具有用于隔离所述血栓远端区域的闭塞气囊（202）的导丝（200） 输液导管（300），用于在压力下将药物或其它药剂递送到远离血栓的区域中。 优选地，引导导管的内腔（122）用于抽吸靠近血栓的材料。 内腔（122）可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。 然后将过滤的药物或溶解剂再次送入远端区域。 以这种方式回收药物或溶解剂降低了程序的成本。 本发明的系统和方法可用于治疗体内流明或容器中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

公开(公告)号：WO1997007740A1

公开(公告)日：1997-03-06

申请号：PCT/US1996013629

申请日：1996-08-22

Applicant: INTERVENTIONAL INNOVATIONS CORPORATION

Inventor： INTERVENTIONAL INNOVATIONS CORPORATION ,  CHORNENKY, Victor, I. ,  FORMAN, Michael, R.

IPC: A61B06/00

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  A61N2005/1003 ,  H01J35/32 ,  H01J2201/304 ,  H01J2201/306

Abstract: A catheter for emitting radiation is disclosed, comprising a catheter shaft (104), and an x-ray unit (102) attached to the distal end of the catheter shaft. The x-ray unit comprises an anode (112), and a cathode (110) coupled to an insulator (108) to define a vacuum chamber (106). The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten, and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4mm, and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.

Abstract translation: 公开了一种用于发射辐射的导管，包括导管轴（104）和附接到导管轴的远端的x射线单元（102）。 x射线单元包括阳极（112）和耦合到绝缘体（108）以限定真空室（106）的阴极（110）。 阴极优选为例如涂覆有碳化钛的石墨或石墨的场致发射阴极。 阳极优选为钨，绝缘体优选为热解氮化硼。 X射线单元优选地通过同轴电缆耦合到电压源。 阳极优选为重金属，例如钨。 阴极也可以是铁电材料。 x射线单元可以具有小于约4mm的直径，并且长度小于约15mm。 还公开了导管的使用方法。 本发明的导管可用于照射血管成形术程序的部位以防止再狭窄。 它也可以用于治疗身体的任何血管，腔或腔中的其他病症。

公开(公告)号：EP0852509A1

公开(公告)日：1998-07-15

申请号：EP96933153.0

申请日：1996-09-26

Applicant: Interventional Innovations Corporation

Inventor： CHORNENKY, Victor, I. ,  FORMAN, Michael, R.

IPC: A61F2 ,  A61M25

CPC classification number: A61M25/09 ,  A61M25/007 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0047 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/1052 ,  A61M2205/36

Abstract: Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter (110) with an occlusion balloon (114) for isolating the region proximal to the thrombus, a guide wire (200) with an occlusion balloon (202) for isolating the region distal to the thrombus, and an infusion catheter (300) for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen (122) of the guide catheter is preferably provided to evacuate material proximal to the thrombus. The lumen (122) can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body as well.

公开(公告)号：EP0847249A1

公开(公告)日：1998-06-17

申请号：EP96929018.0

申请日：1996-08-22

Applicant: Interventional Innovations Corporation

Inventor： CHORNENKY, Victor, I. ,  FORMAN, Michael, R.

IPC: A61N5 ,  H01J35

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  A61N2005/1003 ,  H01J35/32 ,  H01J2201/304 ,  H01J2201/306

Abstract: A catheter for emitting radiation is disclosed, comprising a catheter shaft (104), and an x-ray unit (102) attached to the distal end of the catheter shaft. The x-ray unit comprises an anode (112), and a cathode (110) coupled to an insulator (108) to define a vacuum chamber (106). The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten, and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4mm, and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.