-
1.发明授权BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY 有权粘合剂组合物和一种用于处理POOR可压缩药品的预定大小的和脆弱片剂
公开(公告)号：EP1620074B1
公开(公告)日：2012-12-12
申请号：EP04749697.1
申请日：2004-04-01
Applicant: ISP INVESTMENTS INC.
Inventor： HALDAR, Rama , ZAMORA, John , RAY, Dipan, B. , DREFKO, William , DUBROWNY, Greg , ETIENNE, Sidney
IPC: A61K9/20
CPC classification number: A61K9/2027
-
2.发明公开BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY 有权粘合剂组合物和一种用于处理POOR可压缩药品的预定大小的和脆弱片剂
公开(公告)号：EP1620074A2
公开(公告)日：2006-02-01
申请号：EP04749697.1
申请日：2004-04-01
Applicant: ISP INVESTMENTS INC.
Inventor： HALDAR, Rama , ZAMORA, John , RAY, Dipan, B. , DREFKO, William , DUBROWNY, Greg , ETIENNE, Sidney
IPC: A61K9/20
CPC classification number: A61K9/2027
Abstract: Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10°C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.
-
Search Results
2
records
(took 0.021 seconds)
