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1.发明申请
公开(公告)号：WO2007032969A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/034585
申请日：2006-09-06
Applicant: ISP INVESTMENTS INC. , HALDAR, Rama , RAY, Dipan, B. , DREFKO, William , ETIENNE, Sidney
Inventor： HALDAR, Rama , RAY, Dipan, B. , DREFKO, William , ETIENNE, Sidney
Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
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Patent Agency Ranking
公开(公告)号：WO2002076429A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/004387
申请日：2002-02-13
Applicant: ISP INVESTMENTS INC.
Inventor： MORONI, Antonio , DREFKO, William
IPC: A61K9/14
CPC classification number: A61K9/205
Abstract: A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50 % sodium alginate, (b) 2 to 15 % propylene glycol alginate and (c) 40 to 80 % of a pharmaceutical medicament.
Abstract translation: pH依赖性缓释药物递送组合物，其能够形成片剂或丸粒，其中释放由通过pH依赖性凝胶材料和pH非依赖性胶凝材料的相互作用形成的扩散屏障控制，包括 包含（a）10-50％藻酸钠，（b）2-15％丙二醇藻酸盐和（c）40-80％药物的聚合物基质。
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公开(公告)号：WO2002098393A1
公开(公告)日：2002-12-12
申请号：PCT/US2002/014180
申请日：2002-05-03
Applicant: ISP INVESTMENTS INC.
Inventor： MORONI, Antonio , NERELLA, Nadhamuni, G. , DREFKO, William
IPC: A61K9/20
CPC classification number: A61K9/284 , A61K9/286 , A61K9/2866
Abstract: A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.
Abstract translation: 包含（a）藻酸钠和（b）聚乙烯吡咯烷酮 - 乙酸乙烯酯共聚物和任选的（c）羟丙基甲基纤维素和/或羟丙基纤维素的混合物的片剂包衣组合物。
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4.发明授权BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY 有权粘合剂组合物和一种用于处理POOR可压缩药品的预定大小的和脆弱片剂
公开(公告)号：EP1620074B1
公开(公告)日：2012-12-12
申请号：EP04749697.1
申请日：2004-04-01
Applicant: ISP INVESTMENTS INC.
Inventor： HALDAR, Rama , ZAMORA, John , RAY, Dipan, B. , DREFKO, William , DUBROWNY, Greg , ETIENNE, Sidney
IPC: A61K9/20
CPC classification number: A61K9/2027
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5.发明公开BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY 有权粘合剂组合物和一种用于处理POOR可压缩药品的预定大小的和脆弱片剂
公开(公告)号：EP1620074A2
公开(公告)日：2006-02-01
申请号：EP04749697.1
申请日：2004-04-01
Applicant: ISP INVESTMENTS INC.
Inventor： HALDAR, Rama , ZAMORA, John , RAY, Dipan, B. , DREFKO, William , DUBROWNY, Greg , ETIENNE, Sidney
IPC: A61K9/20
CPC classification number: A61K9/2027
Abstract: Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10°C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.
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6.发明公开PROCESS AND APPARATUS FOR FORMING AGGLOMERATES OF A POWDER COMPOSITION OF AN ACTIVE AND BINDER 审中-公开方法和制造装置中结块从活动和粘合剂的粉末组合物
公开(公告)号：EP1931759A2
公开(公告)日：2008-06-18
申请号：EP06814182.9
申请日：2006-09-06
Applicant: ISP INVESTMENTS INC.
Inventor： HALDAR, Rama , RAY, Dipan, B. , DREFKO, William , ETIENNE, Sidney
IPC: C11D17/00
CPC classification number: A61K9/2095 , A61K9/1635 , A61K9/1694 , A61K9/2027
Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
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