公开(公告)号：WO1993006837A1

公开(公告)日：1993-04-15

申请号：PCT/US1992006921

申请日：1992-08-21

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  GARELICK, Paul

IPC: A61K31/79

CPC classification number: C08F8/22 ,  A01N59/12 ,  A61K31/79 ,  A61K33/18 ,  A61K47/58 ,  C08F26/10

Abstract: A proces for preparing a water-insoluble or water-soluble PVP-iodine product which comprises intimately mixing water-insoluble PVP or water-soluble PVP having a K-value of 10-20, about 10 to 20 % by weight of iodine powder and about 0.05 to 1 % by weight of isopropanol, heating the reaction mixture at a mixing temperature of room temperature to about 30-60 DEG C for about 0.5 to 6 hours, and heating the mixture at a reaction temperature of about 65 to 98 DEG C for about 10-24 hours, generally at least 18 hours, to form a stable, uniform, free-flowing powder.

Abstract translation: 制备水不溶性或水溶性PVP-碘产物的方法，其包括将K值为10-20，约10至20重量％的碘粉末的水不溶性PVP或水溶性PVP与 约0.05-1重量％的异丙醇，在室温至约30-60℃的混合温度下加热反应混合物约0.5至6小时，并在约65至98℃的反应温度下加热该混合物 约10-24小时，通常至少18小时，以形成稳定，均匀的自由流动的粉末。

公开(公告)号：WO1993019727A1

公开(公告)日：1993-10-14

申请号：PCT/US1993001398

申请日：1993-02-18

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  GARELICK, Paul ,  LIEBERMAN, Herbert, A.

IPC: A61K07/16

CPC classification number: A61K8/19 ,  A61K8/8164 ,  A61Q11/00

Abstract: A toothpaste composition includes the strontium salt of maleic anhydride-methyl vinyl ether copolymer, which is capable of desensitizing the nerve endings of a tooth in saliva or water.

公开(公告)号：WO2008021873A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075467

申请日：2007-08-08

Applicant: ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  LINDSTROM, Susan, M. ,  GARELICK, Paul

Inventor： MERIANOS, John, J. ,  LINDSTROM, Susan, M. ,  GARELICK, Paul

IPC: A61K9/14 ,  A61K39/395

CPC classification number: A61K8/8176 ,  A61K8/37 ,  A61K2800/52 ,  A61K2800/524 ,  A61Q19/00

Abstract: The present invention is a directed to a composition and method of solubilizing and stabilizing a liquid preservative composition containing an alkyl paraben ingredient which comprises including polyvinyl pyrrolidone (PVP) in said composition. The compositions are particularly useful in personal care products.

Abstract translation: 本发明涉及一种增溶和稳定含有对羟基苯甲酸烷基酯成分的液体防腐剂组合物的组合物和方法，其包括在所述组合物中包括聚乙烯吡咯烷酮（PVP）。 组合物特别适用于个人护理产品。

公开(公告)号：WO2005102276A1

公开(公告)日：2005-11-03

申请号：PCT/US2005/008370

申请日：2005-03-11

Applicant: ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  GARELICK, Paul ,  LINDSTROM, Susan, M.

Inventor： MERIANOS, John, J. ,  GARELICK, Paul ,  LINDSTROM, Susan, M.

IPC: A61K9/00

CPC classification number: A61K31/075 ,  A61K8/34 ,  A61K8/345 ,  A61K8/44 ,  A61K31/325 ,  A61K31/425 ,  A61Q17/005 ,  Y02A50/473 ,  A61K2300/00

Abstract: What is described herein are antimicrobial compositions which are defined blends of a l,2-diol and pbenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity is potentiated by the addition thereto of small amounts of a co-biocide for which the blend acts as a delivery system for the otherwise water-insoluble co-biocide.

Abstract translation: 本文所述的是抗微生物组合物，其是对细菌，真菌和霉菌孢子具有广泛活性的1,2-二醇和对苯氧基乙醇的定义的共混物。 通过加入少量的共杀生物剂来增强该活性，其中共混物作为其它水不溶性助杀生物剂的递送系统。

公开(公告)号：WO2004071412A2

公开(公告)日：2004-08-26

申请号：PCT/US2004/002923

申请日：2004-02-02

Applicant: ISP INVESTMENTS INC.

Inventor： MERIANOS, John, J. ,  GARELICK, Paul ,  LINDSTROM, Susan ,  LIU, Xianbin ,  WINKOWSKI, Karen

IPC: A61K

CPC classification number: A01N47/12 ,  A01N43/90 ,  A01N43/76 ,  A01N25/02 ,  A01N2300/00

Abstract: This invention relates to a broad spectrum antimicrobial composition, effective against gram negative and gram positive bacteria and fungi, which comprises a synergistic composition comprising iodopropynyl butyl carbamate and a bicyclic hydroxymethyl oxazolidine containing less than 0.1% of free formaldehyde.

Abstract translation: 本发明涉及对革兰氏阴性和革兰氏阳性细菌和真菌有效的广谱抗微生物组合物，其包含含有碘代丙炔基丁基氨基甲酸酯和含有少于0.1％游离基的双环羟甲基恶唑烷的协同组合物 甲醛

公开(公告)号：WO1992019230A1

公开(公告)日：1992-11-12

申请号：PCT/US1992002540

申请日：1992-04-01

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  LOGIN, Robert, B. ,  GARELICK, Paul

IPC: A61K07/20

CPC classification number: A61Q11/00 ,  A01N59/00 ,  A61K8/22 ,  A61K8/8176 ,  A01N25/24 ,  A01N25/22 ,  A01N25/10 ,  A01N25/02 ,  A01N2300/00

Abstract: What is provided herein is a stabilized, aqueous, film-forming, antimicrobial composition of hydrogen peroxide. The active, oxygen-generating hydrogen peroxide component in the composition is stabilized in an aqueous-polyol solvent system of predetermined polarity containing PVP. In contrast, similar formulations without PVP experienced a loss of peroxide activity upon standing. Suitably, the composition herein includes about 1-20 % by weight hydrogen peroxide, about 0.1-50 % by weight PVP, and about 0.1-80 % by weight of a polyol, the rest being water. Preferably, about 5-20 % by weight of water is present in the composition. Additional solvents may be included therein, such as alcohols, ether oxides, esters, triglycerides of fatty acids, hydrocarbons, N-vinyl lactams, silicone oils, and polyether oligomers.

公开(公告)号：WO2007140146A3

公开(公告)日：2007-12-06

申请号：PCT/US2007/069247

申请日：2007-05-18

Applicant: ISP INVESTMENTS INC. ,  MERIANOS, John J. ,  GARELICK, Paul ,  LINDSTROM, Susan M.

Inventor： MERIANOS, John J. ,  GARELICK, Paul ,  LINDSTROM, Susan M.

IPC: A61K31/27 ,  A01N1/00

Abstract: An antimicrobial composition of 3-iodo-2-propynylbutyl carbamate (IPBC) and 1,3-butylene glycol (BG) as solvent, in a defined weight ratio, preferably 9-11% IPBC and 89-91% BG, and personal care formulations including the composition in an amount of about 0.1-0.2% therein, at a pH of 4-9, is described.

公开(公告)号：WO1993015017A1

公开(公告)日：1993-08-05

申请号：PCT/US1993000202

申请日：1993-01-11

Applicant: ISP INVESTMENTS, INC.

Inventor： ISP INVESTMENTS, INC. ,  LOGIN, Robert, B. ,  MERIANOS, John, J. ,  BISS, Russell, B. ,  GARELICK, Paul

IPC: C01B15/01

CPC classification number: C11D3/3945 ,  A01N59/00 ,  A61K8/22 ,  A61K8/42 ,  A61K8/8176 ,  A61Q5/08 ,  A61Q11/00 ,  C01B15/037 ,  C11D3/3776 ,  C11D3/394 ,  A01N2300/00

Abstract: Urea-hydrogen peroxide-polyvinylpyrrolidone (PVP) in the form of a free-flowing powder is stable against decomposition in water and alcohol solvents. The product is obtained by spraying an aqueous solution of urea-hydrogen peroxide onto a fluidized bed of PVP at a rate of about 0.5-30 g of solution/minute/kg PVP in the bed, preferably, about 1-3 g/min/kg PVP, and drying. The product contains about 5-20 % by weight H2O2 and less than about 5 % water.

公开(公告)号：EP0480999A1

公开(公告)日：1992-04-22

申请号：EP90911165.0

申请日：1990-06-18

Applicant: ISP INVESTMENTS INC.

Inventor： MERIANOS, John, J. ,  GARELICK, Paul

IPC: A61K31 ,  A61P31 ,  C07D207 ,  C08G73

CPC classification number: C07D207/27

Abstract: Des bisbiguanides polymères antimicrobiens coiffés de groupes de pyrrolidonyle d'alkylène dont la formule est (I), où X est l'alkylène C2-C4; Y est un groupe bivalent en pont; et n est au moins 2; et des sels d'addition acide de celles-ci.

公开(公告)号：EP1734922B1

公开(公告)日：2013-06-12

申请号：EP05728244.4

申请日：2005-03-11

Applicant: ISP INVESTMENTS INC.

Inventor： MERIANOS, John, J. ,  GARELICK, Paul ,  LINDSTROM, Susan, M.

IPC: A61K9/00 ,  A01N25/34 ,  A61L9/01

CPC classification number: A61K31/075 ,  A61K8/34 ,  A61K8/345 ,  A61K8/44 ,  A61K31/325 ,  A61K31/425 ,  A61Q17/005 ,  Y02A50/473 ,  A61K2300/00

Abstract: What is described herein are antimicrobial compositions which are defined blends of a 1,2-diol and phenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity is potentiated by the addition thereto of small amounts of a co-biocide for which the blend acts as a delivery system for the otherwise water-insoluble co-biocide.