公开(公告)号：WO2002098393A1

公开(公告)日：2002-12-12

申请号：PCT/US2002/014180

申请日：2002-05-03

Applicant: ISP INVESTMENTS INC.

Inventor： MORONI, Antonio ,  NERELLA, Nadhamuni, G. ,  DREFKO, William

IPC: A61K9/20

CPC classification number: A61K9/284 ,  A61K9/286 ,  A61K9/2866

Abstract: A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.

Abstract translation: 包含（a）藻酸钠和（b）聚乙烯吡咯烷酮 - 乙酸乙烯酯共聚物和任选的（c）羟丙基甲基纤维素和/或羟丙基纤维素的混合物的片剂包衣组合物。

公开(公告)号：WO2003011253A1

公开(公告)日：2003-02-13

申请号：PCT/US2002/014586

申请日：2002-05-10

Applicant: ISP INVESTMENTS INC.

Inventor： MORONI, Antonio ,  NERELLA, Nadhamuni, G. ,  DU BROWNY, Gregory

IPC: A61K9/14

CPC classification number: A61K9/2054 ,  A61K9/2027

Abstract: A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.

Abstract translation: 一种协同填充剂组合物，其用于制备具有低压缩力的足够片剂硬度和低脆性的药物片剂，以防止在进一步加工时对片剂的损害，并且不需要片剂大小的显着增加，包括（a）PVP- VA共聚物和（b）微晶纤维素。

公开(公告)号：WO2002076429A1

公开(公告)日：2002-10-03

申请号：PCT/US2002/004387

申请日：2002-02-13

Applicant: ISP INVESTMENTS INC.

Inventor： MORONI, Antonio ,  DREFKO, William

IPC: A61K9/14

CPC classification number: A61K9/205

Abstract: A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50 % sodium alginate, (b) 2 to 15 % propylene glycol alginate and (c) 40 to 80 % of a pharmaceutical medicament.

Abstract translation: pH依赖性缓释药物递送组合物，其能够形成片剂或丸粒，其中释放由通过pH依赖性凝胶材料和pH非依赖性胶凝材料的相互作用形成的扩散屏障控制，包括 包含（a）10-50％藻酸钠，（b）2-15％丙二醇藻酸盐和（c）40-80％药物的聚合物基质。

公开(公告)号：EP1416918B1

公开(公告)日：2006-05-31

申请号：EP02734286.4

申请日：2002-05-10

Applicant: ISP INVESTMENTS INC.

Inventor： MORONI, Antonio ,  NERELLA, Nadhamuni, G. ,  DU BROWNY, Gregory

IPC: A61K9/20

CPC classification number: A61K9/2054 ,  A61K9/2027

Abstract: A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.

公开(公告)号：EP1416918A1

公开(公告)日：2004-05-12

申请号：EP02734286.4

申请日：2002-05-10

Applicant: ISP INVESTMENTS INC.

Inventor： MORONI, Antonio ,  NERELLA, Nadhamuni, G. ,  DU BROWNY, Gregory

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20

CPC classification number: A61K9/2054 ,  A61K9/2027

Abstract: A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.