公开(公告)号：US10280142B2

公开(公告)日：2019-05-07

申请号：US15819180

申请日：2017-11-21

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro Kuninobu ,  Motomu Kanai ,  Haruka Ida ,  Mitsumi Nishi

IPC: C07D213/53 ,  B01J31/22 ,  C07F15/00 ,  B01J31/18

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group; X represents an oxygen atom or a sulfur atom; n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1; R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; and n represents a number of 1 to 4).

公开(公告)号：US10188671B2

公开(公告)日：2019-01-29

申请号：US15555721

申请日：2016-03-04

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Yusuke Shimizu ,  Atsuhiko Taniguchi ,  Kounosuke Oisaki ,  Yoichiro Kuninobu

IPC: A61K31/69 ,  C07F5/02 ,  A61P25/28 ,  A61P3/10 ,  A61P25/16 ,  C07D401/14 ,  C07D455/04 ,  C07D207/44 ,  C07D207/456 ,  A61K31/4025 ,  A61K31/4725 ,  C07D207/46 ,  C07D215/06 ,  A61K41/00

Abstract: Provided is a compound which is useful as an in vivo applicable, amyloid-oxygenating catalyst selective for amyloid and applicable not only to an Aβ peptide, but also to other amyloids and a drug containing the compound for preventing and/or treating amyloid-related diseases. Disclosed is a boron-dipyrrin complex represented by the following formula (1)

公开(公告)号：US09908852B2

公开(公告)日：2018-03-06

申请号：US15114347

申请日：2015-01-29

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Yoichiro Kuninobu ,  Motomu Kanai ,  Haruka Ida ,  Mitsumi Nishi

IPC: C07D213/53 ,  B01J31/22 ,  C07F15/00

CPC classification number: C07D213/53 ,  B01J31/22 ,  B01J2231/40 ,  B01J2531/827 ,  C07F15/0033

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general formula (1): (wherein A represents a single bond, a vinylene group or an ethynylene group; X represents an oxygen atom or a sulfur atom; n pieces of R1 may be the same or different, and R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a cyano group, a nitro group, or an alkoxycarbonyl group, or two adjacent R1 may form a saturated or unsaturated ring structure optionally containing a hetero atom together with the carbon atoms bonded to the two R1; R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, or an optionally substituted aryloxy group; and n represents a number of 1 to 4).

公开(公告)号：US11773052B2

公开(公告)日：2023-10-03

申请号：US16489563

申请日：2018-03-02

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Hideo Nagashima ,  Atsushi Tahara ,  Ikumi Kitahara ,  Yoichiro Kuninobu

IPC: C07C211/55 ,  C07C255/58 ,  C07D265/38 ,  C07D285/14 ,  C07F5/02 ,  C09K11/06

CPC classification number: C07C211/55 ,  C07C255/58 ,  C07D265/38 ,  C07D285/14 ,  C07F5/02 ,  C09K11/06

Abstract: Provided are a donor-acceptor type compound having a novel structure and its use.
An enamine compound represented by general formula (1)




(in the formula:

R1 represents an electron-withdrawing group;
A represents a divalent aromatic hydrocarbon group which may contain a substituent, a divalent aromatic heterocyclic group which may contain a substituent or a divalent unsaturated aliphatic hydrocarbon group which may contain a substituent;
R2 represents a hydrogen atom or a hydrocarbon group which may contain a substituent;
R3 and R4 are the same or different from each other and represent an aromatic hydrocarbon group which may contain a substituent or an aromatic heterocyclic group which may contain a substituent, or R3 and R4 together form an optionally substituted bicyclic aromatic heterocyclic group containing two or more nitrogen atoms or a nitrogen atom and an oxygen atom or a sulfur atom, or a tricyclic aromatic heterocyclic group which may contain a substituent; and
R2 and A, or R2 and R3 may together form a cyclic structure).