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    Curcumin-boron complex and pharmaceutical containing same
    2.
    发明授权
    Curcumin-boron complex and pharmaceutical containing same 审中-公开

    公开(公告)号：US10669287B2

    公开(公告)日：2020-06-02

    申请号：US16087017

    申请日：2017-03-21

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Jizhi Ni ,  Atsuhiko Taniguchi

    IPC: C07F5/02 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61K31/69

    Abstract: Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.

    Amide compound and pharmaceutical comprising same
    3.
    发明授权
    Amide compound and pharmaceutical comprising same 有权

    公开(公告)号：US09796677B2

    公开(公告)日：2017-10-24

    申请号：US15100866

    申请日：2014-12-09

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Takushi Araya

    IPC: A61K31/44 ,  A61K31/505 ,  C07D213/81 ,  C07D239/28 ,  C07D239/30

    CPC classification number: C07D213/81 ,  C07D239/30

    Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

    Benzothiazole compound and medicine containing same
    5.
    发明授权
    Benzothiazole compound and medicine containing same 有权

    公开(公告)号：US09932333B2

    公开(公告)日：2018-04-03

    申请号：US15326320

    申请日：2015-07-15

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Atsuhiko Taniguchi ,  Yusuke Shimizu

    IPC: C07D455/04 ,  C07D417/04

    CPC classification number: C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

    Abstract: It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to Aβ peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R2 and R4 optionally together form an alkylene group; and R5 represents an anion.

    Cyclic peptide and pharmaceutical product containing same
    6.
    发明授权
    Cyclic peptide and pharmaceutical product containing same 有权

    公开(公告)号：US09745349B2

    公开(公告)日：2017-08-29

    申请号：US14648834

    申请日：2013-10-18

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Daisuke Sasaki ,  Yuki Kobayashi

    IPC: C07K7/64 ,  A61K38/00 ,  C07K7/06

    CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06

    Abstract: A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y1-Y2 (1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y1 and Y2, which are identical to or different from each other, each represent a group represented by formula (2): where Ar1 represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; and n is an integer from 0 to 2. In the cyclic peptide has an α-amino group at the amino terminus of the amino acid sequence which is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.

    Curcumin-boron complex and pharmaceutical containing same
    7.
    发明授权
    Curcumin-boron complex and pharmaceutical containing same 有权

    公开(公告)号：US10626128B2

    公开(公告)日：2020-04-21

    申请号：US16087017

    申请日：2017-03-21

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Jizhi Ni ,  Atsuhiko Taniguchi

    IPC: C07F5/02 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61K31/69

    Abstract: Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.

    Curcumin-boron complex and pharmaceutical containing same
    8.
    发明授权
    Curcumin-boron complex and pharmaceutical containing same 有权

    公开(公告)号：US10526348B2

    公开(公告)日：2020-01-07

    申请号：US16087017

    申请日：2017-03-21

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Jizhi Ni ,  Atsuhiko Taniguchi

    IPC: C07F5/02 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61K31/69

    Abstract: Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.

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