公开(公告)号：EP1731501A1

公开(公告)日：2006-12-13

申请号：EP05720950.4

申请日：2005-03-10

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  AKIYAMA, Ryo

IPC: C07C231/12 ,  C07C231/10 ,  C07C233/47 ,  C07C233/82 ,  C07C275/18 ,  B01J31/06 ,  C07B61/00 ,  C08L25/02 ,  C08L29/10

CPC classification number: C08F212/08 ,  B01J31/06 ,  B01J2531/0211 ,  C07C231/12 ,  C07C273/1854 ,  C07C2601/14 ,  C08F8/42 ,  C08F12/22 ,  C08F12/26 ,  C08F212/14 ,  C07C233/47 ,  C07C233/84 ,  C07C275/18

Abstract: A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or shorter to conduct the amidocarbonylation reaction. Thus, an N-acyl-α-amino acid can be more efficiently and selectively synthesized in a clean reaction system. Also provided is a catalyst for use in the method.

Abstract translation: 一种醛化合物，酰胺化合物和一氧化碳之间的酰胺基羰基化反应的新方法，包括使用含有长轴长度为20nm或更短的钯簇的钯负载交联聚合物组合物进行酰胺基羰基化反应 。 因此，N-酰基-α-氨基酸可以在清洁的反应体系中更有效地和选择性地合成。 还提供了用于该方法的催化剂。

公开(公告)号：EP1738824A1

公开(公告)日：2007-01-03

申请号：EP05720221.0

申请日：2005-03-08

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  AKIYAMA, Ryo ,  KAWAI, Nobuyuki ,  TAKEUCHI, Masahiro

IPC: B01J31/26 ,  B01J31/28 ,  C07C45/72 ,  C07C49/245 ,  C07C49/255 ,  C07C49/507 ,  C07C49/76 ,  C07C49/83

CPC classification number: C07C67/347 ,  B01J13/14 ,  B01J31/165 ,  B01J31/2239 ,  B01J31/226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/842 ,  B01J2540/22 ,  C07C45/46 ,  C07C45/511 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C227/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  Y02P20/584 ,  C07C69/732 ,  C07C69/738 ,  C07C69/757 ,  C07C229/34

Abstract: The objective is to incarcerate a Lewis acid metal in a polymer and to make this catalyst recoverable while maintaining its function as a Lewis acid metal catalyst.
The present invention is a polymer-incarcerated Lewis acid metal catalyst in which a Lewis acid metal is incarcerated in a crosslinked polymer and the crosslinked polymer is crosslinked using the crosslinking groups contained in a crosslinkable polymer. The polymer incarcerated Lewis acid metal catalyst is characterized by the crosslinkable polymer containing at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups, and the hydrophobic substituents contain aromatic substituents. This crosslinkable polymer preferably comprises at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups and a monomer unit containing hydrophobic substituents. This catalyst can be obtained by subjecting a polymer micelle incarcerated Lewis acid metal obtained by mixing an organic solution containing a crosslinkable polymer and a Lewis acid metal with a bad solvent to a crosslinking reaction. This catalyst is useful as a catalyst in aldol reactions, cyanolation reactions, allylation reactions, Michael reactions, Mannich reactions, Diels Alder reactions and Friedel Crafts reactions.

公开(公告)号：EP1987880A1

公开(公告)日：2008-11-05

申请号：EP07714975.5

申请日：2007-02-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  OYAMADA, Hidekazu ,  AKIYAMA, Ryo ,  NAITO, Takeshi

IPC: B01J31/28 ,  B01J31/26 ,  B01J31/38 ,  B01J37/03 ,  B01J37/08 ,  B01J37/34 ,  C07C2/86 ,  C07C5/03 ,  C07C5/08 ,  C07C15/12 ,  C07C15/18 ,  C07C15/54 ,  C07C67/303 ,  C07C67/343 ,  C07C69/612 ,  C07C69/618 ,  C07C201/14 ,  C07C205/19 ,  C07F7/08 ,  C07F7/18 ,  C07B61/00

CPC classification number: C07C67/303 ,  B01J23/40 ,  B01J23/70 ,  B01J31/124 ,  B01J31/127 ,  B01J31/165 ,  B01J31/26 ,  B01J31/28 ,  B01J35/006 ,  B01J37/0219 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2531/824 ,  B01J2531/828 ,  C07B2200/11 ,  C07C2/861 ,  C07C5/03 ,  C07C5/08 ,  C07C67/343 ,  C07C205/19 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/72 ,  C07F15/0066 ,  C07F15/0086 ,  C07F15/0093 ,  C07C15/54 ,  C07C15/18 ,  C07C69/612 ,  C07C69/618

Abstract: The present invention provides a polysilane-supported transition metal catalysts or a polysilane/inorganic compound-supported transition metal catalysts, wherein various types of transition metals are supported by polysilane compounds, or combination of polysilanes and inorganic compounds. The catalysts of the present invention are hardly soluble in hydrocarbons and alcohols and are useful as catalysts in heterogeneous system for various organic synthetic reactions using the above solvents. Polysilanes supporting transition metals are easily crosslinkable by thermal treatment, microwave irradiation, UV irradiation or chemical methods such as hydrosilylation reaction and are changed to be insoluble in various solvents keeping high catalytic activity. Moreover, the stability and operability of polysilane-supported transition metal catalysts will be improved by the support thereof on inorganic compounds. These polysilane-supported transition metal catalysts show a high catalytic activity in hydrogenation reaction, hydrosilylation reaction, Heck reaction, Suzuki-Miyaura coupling reactions and the like. The catalyst is easily recoverable and reusable and the leakage of metals is extremely few.

Abstract translation: 本发明提供一种聚硅烷负载的过渡金属催化剂或聚硅烷/无机化合物负载的过渡金属催化剂，其中各种类型的过渡金属由聚硅烷化合物或聚硅烷和无机化合物的组合负载。 本发明的催化剂几乎不溶于烃和醇，并且可用作用于使用上述溶剂的各种有机合成反应的异相体系中的催化剂。 支撑过渡金属的聚硅烷通过热处理，微波照射，UV照射或氢化硅烷化反应等化学方法易于交联，并且改变为不溶于保持高催化活性的各种溶剂中。 此外，通过其对无机化合物的支持，聚硅烷负载的过渡金属催化剂的稳定性和可操作性将得到改善。 这些聚硅烷负载的过渡金属催化剂在氢化反应，氢化硅烷化反应，Heck反应，Suzuki-Miyaura偶联反应等中显示出高的催化活性。 催化剂易于回收和再利用，金属的泄漏极少。

公开(公告)号：EP1739104B1

公开(公告)日：2014-07-09

申请号：EP05720120.4

申请日：2005-03-07

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  OKAMOTO, Kuniaki ,  AKIYAMA, Ryo ,  OHNO, Keiji ,  INAGAKI, Yoshio

IPC: C08F212/08 ,  B01J35/00 ,  C07C67/343 ,  C07C69/618 ,  C07B61/00 ,  B01J31/16

CPC classification number: C07C67/31 ,  B01J31/069 ,  B01J31/165 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C17/14 ,  C07C45/68 ,  C07C49/796 ,  C07C67/343 ,  C08F212/08 ,  C08F212/14 ,  C07C22/04 ,  C07C69/732 ,  C07C69/618

公开(公告)号：EP1739104A1

公开(公告)日：2007-01-03

申请号：EP05720120.4

申请日：2005-03-07

Applicant: Japan Science and Technology Agency ,  Wako Pure Chemical Industries, Ltd. ,  FUJI PHOTO FILM CO., LTD. ,  Kobayashi, Shu

Inventor： KOBAYASHI, Shu ,  OKAMOTO, Kuniaki ,  AKIYAMA, Ryo ,  OHNO, Keiji ,  INAGAKI, Yoshio

IPC: C08F212/08 ,  B01J31/28 ,  C07C67/343 ,  C07C69/618 ,  C07B61/00

CPC classification number: C07C67/31 ,  B01J31/069 ,  B01J31/165 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C17/14 ,  C07C45/68 ,  C07C49/796 ,  C07C67/343 ,  C08F212/08 ,  C08F212/14 ,  C07C22/04 ,  C07C69/732 ,  C07C69/618

Abstract: The objective is to present compositions obtained by supporting by polymers micro clusters of transition metals and the like that are useful as catalysts in various reactions and, once used, are readily recovered and reused.
A polymer-supported metal cluster composition is obtained by supporting a transition metal by a cross-linked polymer, and the polymer-supported cluster composition is characterized by the cross-linked polymer obtained by cross-linking of a cross-linkable polymer containing a hydrophilic side chain and a hydrophobic side chain group having a cross-linkable functional group. This polymer-supported metal cluster composition is, for example, preferably formed by first forming a micelle composed of the metal clusters supported by the cross-linkable polymer in a suitable solution and subsequently subjecting the cross-linkable polymer to a cross-linking reaction. The composition is useful as a catalyst and the like in hydrogenation reactions, dehydrogenation reactions, allylic substitution reactions, oxidation reactions, coupling reactions and carbonylation reactions.

Abstract translation: 本发明的目的是提供通过聚合物支持的组合物，其可用于各种反应中用作催化剂的过渡金属等的微簇，并且一旦使用，可容易地回收和重复使用。 聚合物负载的金属簇组合物通过用交联聚合物负载过渡金属而获得，聚合物负载的簇组合物的特征在于通过交联含有亲水性的可交联聚合物而获得的交联聚合物 侧链和具有可交联官能团的疏水侧链基团。 该聚合物负载的金属簇组合物例如优选通过首先在合适的溶液中形成由可交联聚合物负载的金属簇构成的胶束，然后使可交联聚合物进行交联反应而形成。 该组合物可用作氢化反应，脱氢反应，烯丙基取代反应，氧化反应，偶联反应和羰基化反应中的催化剂等。