公开(公告)号：EP1489106B1

公开(公告)日：2012-05-09

申请号：EP03710299.3

申请日：2003-03-11

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J31/06

CPC classification number: C08F8/42 ,  B01J31/1658 ,  B01J31/2295 ,  B01J31/24 ,  B01J2231/324 ,  B01J2231/543 ,  B01J2231/643 ,  B01J2531/821 ,  C07B2200/11 ,  C07C29/143 ,  C07C67/333 ,  C07C2601/10 ,  C07D207/48 ,  C07D211/96 ,  C07D225/02 ,  C07D307/28 ,  C07D307/92 ,  C07F15/0046 ,  C07F15/0053 ,  C07C69/74 ,  C07C33/22

Abstract: Novel arene-ruthenium complexes immobilized on polymers as represented by the following formula: [wherein A is an organic polymer whose aromatic rings on the side chains coordinate to Ru; X1 and X2 are each independently halogeno; and R is an optionally substituted hydrocarbon group], which can be prepared by a simple process and are stable, easy of recovery, and applicable to various organic syntheses by virtue of their high catalytic activities; catalysts consisting of the complexes; and novel processes for organic syntheses including ring-opening metatheses of olefins and reduction of carbonyl by the use of the catalysts.

公开(公告)号：EP1391198B1

公开(公告)日：2008-01-02

申请号：EP02722714.9

申请日：2002-04-19

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  HANADA, Kentaro, Furuvu Kajigaya 202

IPC: A61K31/165 ,  A61P43/00 ,  C07C233/18

CPC classification number: C07C233/18 ,  A61K31/165

Abstract: A novel sphingolipid synthesis inhibitor comprising a compound represented by the general formula (A). Especially preferably, the novel sphingolipid synthesis inhibitor comprises a (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)alkanamide in which the alkanoyl group has 8 to 16 carbon atoms. (A) (In the formula, X is aliphatic alkyl, preferably C7-15 aliphatic alkyl.)

公开(公告)号：EP1852412A1

公开(公告)日：2007-11-07

申请号：EP06712459.4

申请日：2006-01-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MANABE, Kei

IPC: C07C45/75 ,  B01J31/22 ,  C07B53/00 ,  C07C49/497 ,  C07C49/513 ,  C07C49/82 ,  C07B61/00

CPC classification number: B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

Abstract: A silicon enolate represented by the following formula (Formula 1)

(in the formula, R 5 to R 7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R 5 and R 7 are different, R 6 is not a hydrogen atom, each R 8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf) 3 .

Abstract translation: 由下式（式1）（式中，R 5〜R 7表示的硅烯醇表示氢原子，脂族烃基，单环或多环脂环族烃基，单环或多环芳族或芳族 - 脂族烃基或杂环基团 中，R 5和R 7是不同的，R 6不是氢原子，各R 8可以相同或不同，并且darstellt甲基，乙基或异丙基）和甲醛被允许在水溶液或混合反应 溶剂的水和有机溶剂中通过混合的配位体，包括手性联吡啶化合物或与其对映体和Bi（OTF）获得的催化剂的存在下进行。3

公开(公告)号：EP1063227B1

公开(公告)日：2007-10-31

申请号：EP99939190.7

申请日：1999-03-12

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  OYAMADA, Hidekazu

IPC: C07C243/38 ,  C07C251/80 ,  C07D231/20 ,  C08F8/30 ,  C08G85/00

CPC classification number: C08F8/30 ,  C07C243/38 ,  C07C251/76 ,  C07C251/80

Abstract: A hydrazide fixed to a resin represented by formula (1): P-Q-CO-NH-NH2 wherein P represents a main chain of a polymer constituting the resin and Q represents a hydrocarbon side chain optionally substituted with a substituent which may be boned via a heteroatom, a hydrazone fixed to a resin derived therefrom and represented by following formula: P-Q-CO-NH-N=CH-R and a method for synthesizing pyrazolones in a solid phase using the resin-fixed hydrazone. The invention allows the synthesis of pyrazolones by application of a Mannich type reaction in a solid phase and also allows making an efficient library with respect to various types thereof.

公开(公告)号：EP1203616B1

公开(公告)日：2007-01-10

申请号：EP01912322.3

申请日：2001-03-13

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J31/02 ,  B01J31/12 ,  B01J31/22 ,  C07B53/00 ,  C07C45/45 ,  C07C45/51 ,  C07D323/00 ,  C07F7/24

CPC classification number: C07D323/00 ,  B01J23/14 ,  B01J31/0227 ,  B01J31/2213 ,  B01J2231/341 ,  B01J2531/0258 ,  B01J2531/0266 ,  B01J2531/44 ,  B01J2531/96 ,  B01J2540/20 ,  C07B53/00 ,  C07C45/511

Abstract: A chiral lead catalyst which comprises a lead compound represented by the formula Pb(ORf)2 (wherein Rf represents fluoroalkylsulfonyl) and a chiral crown ether compound having the skeleton represented by the formula (I); and a novel catalyst for asymmetric synthesis which comprises the lead catalyst. The asymmetric-synthesis catalyst, when used to conduct an asymmetric aldol reaction, attains a high yield and high optical selectivity. It has suitability for general-purpose use, and enables a simple reaction operation. Also provided is a method of asymmetric synthesis with the asymmetric-synthesis catalyst.

公开(公告)号：EP1724275A1

公开(公告)日：2006-11-22

申请号：EP05720123.8

申请日：2005-03-07

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07F9/38 ,  B01J31/22 ,  C07B53/00 ,  C07B61/00

CPC classification number: B01J31/1805 ,  B01J2531/16 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056

Abstract: To present a reaction system that efficiently catalyzes an enantio selective asymmetric nucleophilic addition reaction of an α-iminophosphonic acid ester.
An optically active α-amino-γ-oxophosphonic acid derivative is produced through an asymmetric addition reaction of an α-iminophosphonic acid ester and a nucleophilic agent (for example, a silyl enol ether).

Abstract translation: 提供有效催化α-亚氨基膦酸酯的对映选择性不对称亲核加成反应的反应体系。 通过α-亚氨基膦酸酯和亲核试剂（例如甲硅烷基烯醇醚）的不对称加成反应制备光学活性的α-氨基-γ-氧代膦酸衍生物。

公开(公告)号：EP1724251A1

公开(公告)日：2006-11-22

申请号：EP05704190.7

申请日：2005-01-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MANABE, Kei

IPC: C07C45/00 ,  B01J31/14 ,  C07C45/75 ,  C07C49/497 ,  C07C49/733 ,  C07C49/82 ,  C07C327/22

CPC classification number: C07C327/22 ,  C07B53/00 ,  C07C45/512 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C49/747 ,  C07C49/82 ,  C07C49/717 ,  C07C49/713 ,  C07C49/707 ,  C07C49/248

Abstract: The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst.
Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4)

with scandium triflate and the like.

公开(公告)号：EP1577328A1

公开(公告)日：2005-09-21

申请号：EP03780853.2

申请日：2003-12-17

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C08F8/30 ,  B01J31/06 ,  C07C29/40 ,  C07C33/30 ,  C07C241/02 ,  C07C243/38

CPC classification number: C08F8/30 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/06 ,  B01J31/4007 ,  B01J2231/341 ,  C07C29/38 ,  C07C243/38 ,  C07C2601/16 ,  Y02P20/584 ,  C07C33/20

Abstract: Polymer-immobilized form amides characterized by being represented by the general formula:
(wherein R 1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R 2 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon chain which is bonded to R 1 to form a ring; and the solid circle represents a polymer); novel organic catalysts containing the same, which catalysts are free from metallic catalyst components and very easy of recovery from reaction mixtures of synthesis and reuse; polymer-immobilized organic compounds useful as intermediates for synthesis; catalysts containing the same as the active ingredient; and a process for the allylation of aldehydes or hydrazones by the use of these catalysts.

公开(公告)号：EP1724013B1

公开(公告)日：2015-01-28

申请号：EP05720349.9

申请日：2005-03-09

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  ISHITANI, Haruro ,  YAMASHITA, Yasuhiro

IPC: B01J31/22 ,  B01J31/26 ,  C07C15/42 ,  C07C213/04 ,  C07B61/00 ,  C07B53/00 ,  C07C215/44 ,  C07C241/04

CPC classification number: B01J31/223 ,  B01J2231/341 ,  B01J2231/485 ,  B01J2531/0266 ,  B01J2531/57 ,  C07B53/00 ,  C07C221/00 ,  C07C327/22 ,  C07D307/54 ,  C07D333/24 ,  C07C225/06

公开(公告)号：EP2269979B1

公开(公告)日：2014-04-16

申请号：EP09720699.9

申请日：2009-02-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  YAMASHITA, Yasuhiro ,  SEKI, Kazutaka

IPC: C07C251/20 ,  B01J31/22 ,  C07B53/00 ,  C07C249/02 ,  C07F9/40 ,  B01J31/02 ,  B01J31/18 ,  C07C271/22 ,  C07C251/24 ,  C07D307/52 ,  C07F9/655 ,  C07F9/6553

CPC classification number: C07F9/4056 ,  B01J31/0222 ,  B01J31/0237 ,  B01J31/0251 ,  B01J31/0271 ,  B01J31/1805 ,  B01J2231/346 ,  B01J2531/20 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C251/24 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/18 ,  C07D307/52 ,  C07F9/4006 ,  C07F9/65515 ,  C07F9/655345