公开(公告)号：EP1724013B1

公开(公告)日：2015-01-28

申请号：EP05720349.9

申请日：2005-03-09

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  ISHITANI, Haruro ,  YAMASHITA, Yasuhiro

IPC: B01J31/22 ,  B01J31/26 ,  C07C15/42 ,  C07C213/04 ,  C07B61/00 ,  C07B53/00 ,  C07C215/44 ,  C07C241/04

CPC classification number: B01J31/223 ,  B01J2231/341 ,  B01J2231/485 ,  B01J2531/0266 ,  B01J2531/57 ,  C07B53/00 ,  C07C221/00 ,  C07C327/22 ,  C07D307/54 ,  C07D333/24 ,  C07C225/06

公开(公告)号：EP1151987B1

公开(公告)日：2006-10-25

申请号：EP00976327.7

申请日：2000-11-17

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  ISHITANI, Haruro

IPC: C07C39/38 ,  B01J31/02 ,  B01J31/26

CPC classification number: C07C251/24 ,  B01J21/06 ,  B01J21/066 ,  B01J31/0211 ,  B01J31/0231 ,  B01J31/223 ,  B01J2231/348 ,  B01J2531/0266 ,  B01J2531/30 ,  B01J2531/48 ,  B01J2540/22 ,  C07B53/00 ,  C07B2200/07 ,  C07C6/04 ,  C07C39/38 ,  C07C249/02

Abstract: A novel optically active binaphthol derivative with which a higher reaction yield and a higher optical yield (selectivity) can be attained in asymmetric synthesis and which is useful as an asymmetric catalyst, etc.; an asymmetric catalyst comprising the derivative; and a method of asymmetric synthesis. The optically active fluorinated binaphthol derivative is represented by formula (I) wherein R1 and R2 each represents a fluorohydrocarbon group.

公开(公告)号：EP1489072B1

公开(公告)日：2016-01-20

申请号：EP03710300.9

申请日：2003-03-11

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  YAMASHITA, Yasuhiro ,  ISHITANI, Haruro

IPC: C07D231/56

CPC classification number: C07D231/56

公开(公告)号：EP1724013A1

公开(公告)日：2006-11-22

申请号：EP05720349.9

申请日：2005-03-09

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  ISHITANI, Haruro ,  YAMASHITA, Yasuhiro

IPC: B01J31/26 ,  C07C15/42 ,  C07C213/04 ,  C07B61/00 ,  C07B53/00

CPC classification number: B01J31/223 ,  B01J2231/341 ,  B01J2231/485 ,  B01J2531/0266 ,  B01J2531/57 ,  C07B53/00 ,  C07C221/00 ,  C07C327/22 ,  C07D307/54 ,  C07D333/24 ,  C07C225/06

Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula:

(wherein, Y is divalent hydrocarbon and R 1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).

Abstract translation: 不对称反应的催化剂是通过将具有R或S构型的联萘酚结构的五价铌化合物和光学活性的三醇或四醇获得，并且三醇是由下式表示：（worin，Y是二价烃基和R 1为 氢原子，卤素原子，三氟甲基，或烷基或具有至多4个碳原子的烷氧基）。

公开(公告)号：EP1489072A1

公开(公告)日：2004-12-22

申请号：EP03710300.9

申请日：2003-03-11

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  YAMASHITA, Yasuhiro ,  ISHITANI, Haruro

IPC: C07D231/56

CPC classification number: C07D231/56

Abstract: An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide represented by the following formula (I):

        Zr(OR) 4      (I)

(wherein R is a hydrocarbon group which may have a substituent) with a binaphthol derivative represented by the following formula (II):
(wherein Y 1 and Y 2 are each identical or different and denote a hydrogen atom or a halogen atom, and at least one of Y 1 and Y 2 denotes a halogen atom).

Abstract translation: 腙的分子内Ä3+ 2u环加成反应在具有高立体选择性的温和条件下进行，并且通过使腙衍生物在由下式（I）表示的锆烷氧化物混合得到的不对称催化剂体系存在下反应， ：具有下式（II）表示的联萘酚衍生物的Zr（OR）4（其中R为可具有取代基的烃基）：其中Y 1和Y 2各自相同或相同， 不同，表示氢原子或卤素原子，Y 1和Y 2中的至少一个表示卤素原子）。