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    ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN
    3.
    发明申请
    ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN 审中-公开

    公开(公告)号：US20190352397A1

    公开(公告)日：2019-11-21

    申请号：US16473482

    申请日：2017-12-25

    Applicant: Kyowa Hakko Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

    Inventor： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

    IPC: C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

    Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

    SOLID-PHASE CARRIER INCLUDING IgG-BINDING PEPTIDE, AND IgG SEPERATION METHOD
    4.
    发明申请
    SOLID-PHASE CARRIER INCLUDING IgG-BINDING PEPTIDE, AND IgG SEPERATION METHOD 有权

    公开(公告)号：US20210380637A1

    公开(公告)日：2021-12-09

    申请号：US17284309

    申请日：2019-10-07

    Applicant: KAGOSHIMA UNIVERSITY ,  DAICEL CORPORATION

    Inventor： Yuji ITO ,  Seiichi UCHIMURA

    IPC: C07K1/22 ,  C07K17/00 ,  C07K7/08 ,  B01D15/10 ,  B01D15/38

    Abstract: The purpose of the present invention is to provide a solid-phase carrier on which an IgG-binding peptide is immobilized, the peptide being usable for IgG purification, having resistance to repeated washing with an alkaline solution after IgG purification, and having a high binding affinity for IgG. Specifically, the present invention relates to a solid-phase carrier on which an IgG-binding peptide is immobilized, wherein the two cysteine residues on the outside of the peptide are linked as shown in the following formula: (in the formula, the upper cysteine residue is on the N-terminal side of the peptide, and the lower cysteine residue is on the C-terminal side of the peptide).

    ANTIBODY BINDING TO CELL ADHESION MOLECULE 3
    5.
    发明申请
    ANTIBODY BINDING TO CELL ADHESION MOLECULE 3 有权

    公开(公告)号：US20210147541A1

    公开(公告)日：2021-05-20

    申请号：US17255784

    申请日：2019-06-26

    Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

    Inventor： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Takenao YAMADA ,  Yuji ITO

    IPC: C07K16/28

    Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

    ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN
    6.
    发明申请
    ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN 有权

    公开(公告)号：US20220025044A1

    公开(公告)日：2022-01-27

    申请号：US17399354

    申请日：2021-08-11

    Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

    Inventor： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

    IPC: C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

    Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

    PEPTIDE FUSION PROTEIN
    7.
    发明申请
    PEPTIDE FUSION PROTEIN 有权

    公开(公告)号：US20210332152A1

    公开(公告)日：2021-10-28

    申请号：US17264577

    申请日：2019-08-01

    Applicant: KAGOSHIMA UNIVERSITY ,  DAICEL CORPORATION

    Inventor： Yuji ITO ,  Seiichi UCHIMURA ,  Hiromichi OKURA

    IPC: C07K19/00 ,  C07K14/435 ,  C07K7/08 ,  C07K1/22 ,  C07K17/00

    Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.

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