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    NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL
    1.
    发明申请
    NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL 审中-公开
    新型乙酰乙酸辅酶A还原酶和生产光学活性酒精的方法

    公开(公告)号：WO2005044973A2

    公开(公告)日：2005-05-19

    申请号：PCT/JP2004016666

    申请日：2004-11-10

    Applicant: KANEKA CORP ,  KAWANO SHIGERU ,  YASOHARA YOSHIHIKO

    Inventor： KAWANO SHIGERU ,  YASOHARA YOSHIHIKO

    IPC: C12N20060101 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P13/00 ,  C12P41/00 ,  C12N

    CPC classification number: C12P7/42 ,  C12N9/0004 ,  C12P7/04 ,  C12P7/22 ,  C12P13/002 ,  C12P13/008 ,  C12P41/002 ,  Y02E50/17

    Abstract: A process for easily producing optically active alcohols which are (R)-3-hydroxypentanenitrile, an optically active 3-hydroxybutanoic ester, and an optically active 1-phenylethanol derivative; and a novel enzyme useful for the production of the optically active alcohols, in particular, (R)-3-hydroxypentanenitrile. The enzyme is a novel acetoacetyl-CoA reductase which is capable of asymmetrically reducing 3-ketopentanenitrile to produce (R)-3-hydroxypentanenitrile having an optical purity of 99% e.e. or higher. The process comprises causing the novel enzyme or a known acetoacetyl-CoA reductase to act on each of 3-ketopentanenitrile, an acetoacetic ester, and a 1-phenylethanone derivative to produce the corresponding optically active alcohols.

    Abstract translation: （R）-3-羟基戊腈，光学活性3-羟基丁酸酯和光学活性1-苯基乙醇衍生物的光学活性醇的制造方法， 和用于制备光学活性醇，特别是（R）-3-羟基戊腈的新型酶。 该酶是新型的乙酰乙酰-CoA还原酶，其能够不对称还原3-酮戊腈以产生光学纯度为99％e.e的（R）-3-羟基戊腈。 或更高。 该方法包括使新酶或已知的乙酰乙酰-CoA还原酶作用于3-酮戊腈，乙酰乙酸酯和1-苯基乙酮衍生物中的每一种以产生相应的光学活性醇。

    2.
    发明专利
    未知

    公开(公告)号：AT389010T

    公开(公告)日：2008-03-15

    申请号：AT00942359

    申请日：2000-06-28

    Applicant: KANEKA CORP

    Inventor： KAWANO SHIGERU ,  HORIKAWA MIHO ,  YASOHARA YOSHIHIKO ,  HASEGAWA JUNZO

    IPC: C12N9/02 ,  C12N1/21 ,  C12N15/53 ,  C12N15/63 ,  C12P17/12 ,  C12P17/18 ,  C12P41/00 ,  C12R1/11 ,  C12R1/72

    Abstract: The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives. The present invention also relates to a novel enzyme which can be used in the production method mentioned above, a DNA coding for said enzyme, a recombinant vector having said DNA, and a transformant having said recombinant vector. The invention further relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing the above novel enzyme or the above transformant to act on optically inactive polycyclic pyridineethanol derivatives.

    Process for producing optically active pyridineethanol derivatives
    3.
    发明专利
    Process for producing optically active pyridineethanol derivatives 未知

    公开(公告)号：AU5704100A

    公开(公告)日：2001-02-05

    申请号：AU5704100

    申请日：2000-06-28

    Applicant: KANEKA CORP

    Inventor： KAWANO SHIGERU ,  HORIKAWA MIHO ,  YASOHARA YOSHIHIKO ,  HASEGAWA JUNZO

    IPC: C12N9/02 ,  C12N15/53 ,  C12P17/12 ,  C12P17/18 ,  C12P41/00 ,  C12N15/63 ,  C12N1/21

    Abstract: The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives. The present invention also relates to a novel enzyme which can be used in the production method mentioned above, a DNA coding for said enzyme, a recombinant vector having said DNA, and a transformant having said recombinant vector. The invention further relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing the above novel enzyme or the above transformant to act on optically inactive polycyclic pyridineethanol derivatives.

    Method for purifying and isolating (2s,3s)- or (2r,3s)-halohydrin derivatives
    4.
    发明专利
    Method for purifying and isolating (2s,3s)- or (2r,3s)-halohydrin derivatives 未知

    公开(公告)号：AU3075400A

    公开(公告)日：2000-08-07

    申请号：AU3075400

    申请日：2000-01-21

    Applicant: KANEKA CORP

    Inventor： MAEHARA KATSUJI ,  KAWANO SHIGERU ,  YAMAGUCHI MAKOTO ,  UEDA YASUYOSHI

    IPC: C07C269/08 ,  C07C271/16 ,  C12P13/02 ,  C12P41/00

    Abstract: The present invention has for its object to provide a practical method for the purification and isolation on a commercial scale of said compound (1) or compound (2) in good yield and with high quality. The present invention provides a purification/isolation method of a (2S,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (1) or a (2R,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (2) which comprises, for the purpose of removing contaminant impurity from a mixture containing at least one of said compounds(1) and (2), causing the objective compound (1) or compound (2) to be crystallized in the presence of a solvent comprised of a hydrocarbon solvent and then collecting the obtained crystals.

    5.
    发明专利
    未知

    公开(公告)号：DE60038281T2

    公开(公告)日：2009-03-26

    申请号：DE60038281

    申请日：2000-06-28

    Applicant: KANEKA CORP

    Inventor： KAWANO SHIGERU ,  HORIKAWA MIHO ,  YASOHARA YOSHIHIKO ,  HASEGAWA JUNZO

    IPC: C12N9/02 ,  C12N1/21 ,  C12N15/53 ,  C12N15/63 ,  C12P17/12 ,  C12P17/18 ,  C12P41/00 ,  C12R1/11 ,  C12R1/19 ,  C12R1/72

    Abstract: The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives. The present invention also relates to a novel enzyme which can be used in the production method mentioned above, a DNA coding for said enzyme, a recombinant vector having said DNA, and a transformant having said recombinant vector. The invention further relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing the above novel enzyme or the above transformant to act on optically inactive polycyclic pyridineethanol derivatives.

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