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    METHOD FOR PRODUCING POROUS CELLULOSE BEADS AND ADSORBENT EMPLOYING SAME
    3.
    发明申请
    METHOD FOR PRODUCING POROUS CELLULOSE BEADS AND ADSORBENT EMPLOYING SAME 审中-公开
    生产多孔纤维素珠的方法和使用它的吸附剂

    公开(公告)号：US20160243521A1

    公开(公告)日：2016-08-25

    申请号：US15029551

    申请日：2014-10-14

    Applicant: KANEKA CORPORATION

    Inventor： Asuka HAYASHI ,  Yoshikazu KAWAI ,  Ken-ichiro MORIO

    IPC: B01J20/24 ,  B01J20/30 ,  C07K17/12 ,  C08J9/28 ,  C07K1/22 ,  B01J20/285 ,  C08J9/16

    CPC classification number: B01J20/24 ,  B01J20/285 ,  B01J20/286 ,  B01J20/305 ,  B01J20/3085 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3274 ,  B01J20/3293 ,  C07K1/145 ,  C07K1/22 ,  C07K17/12 ,  C08B15/10 ,  C08J9/16 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0547 ,  C08J2301/00

    Abstract: The objective of the present invention is to provide a method for easily and efficiently producing cellulose beads which have pore shape suitable for an adsorbent and of which adsorption performance is excellent without using highly toxic and highly corrosive auxiliary raw material and without industrially disadvantageous cumbersome step. The method for producing porous cellulose beads according to the present invention is characterized in comprising (a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a crosslinking agent to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.

    Abstract translation: 本发明的目的是提供一种容易且有效地制造具有适合于吸附剂的孔隙形状的纤维素珠粒的方法，其吸附性能优异，而不需要使用高毒性和高腐蚀性的辅助原料，而且在工业上不利的繁琐步骤。 根据本发明的多孔纤维素珠粒的制造方法的特征在于，（a）通过混合低温碱性水溶液和纤维素来制备细纤维素分散液的步骤，（b）通过添加制备混合液体的步骤 （c）通过将混合液体分散在分散介质中制备乳液的步骤，（d）使乳液与凝固溶剂接触的步骤。

    MASS PRODUCTION METHOD OF PLURIPOTENT STEM CELL STOCK
    4.
    发明公开
    MASS PRODUCTION METHOD OF PLURIPOTENT STEM CELL STOCK 审中-公开

    公开(公告)号：US20240352427A1

    公开(公告)日：2024-10-24

    申请号：US18747005

    申请日：2024-06-18

    Applicant: KANEKA CORPORATION

    Inventor： Sho KAMBAYASHI ,  Yoshikazu KAWAI

    IPC: C12N5/074

    CPC classification number: C12N5/0696 ,  C12N2501/603 ,  C12N2501/727

    Abstract: The purpose of the present invention is to produce a large amount of a high-quality pluripotent stem cell stock. A mass production method of a pluripotent stem cell stock that comprises thawing starting cells followed by adhesion culture to thereby stabilize the cell conditions, and then growing the cells to a cell count that enables suspension culture. Subsequently, the cells are suspension cultured while precisely controlling the culture environment to thereby grow a large number of high-quality cells. Then, a stock is prepared at a low temperature from the cells having been grown by the suspension culture.

    METHOD FOR PRODUCING CARDIOMYOCYTE SPHEROIDS
    5.
    发明公开
    METHOD FOR PRODUCING CARDIOMYOCYTE SPHEROIDS 审中-公开

    公开(公告)号：US20230287349A1

    公开(公告)日：2023-09-14

    申请号：US18016266

    申请日：2021-07-13

    Applicant: KANEKA CORPORATION

    Inventor： Yoshikazu KAWAI

    IPC: C12N5/077

    CPC classification number: C12N5/0657 ,  C12N2501/33 ,  C12N2500/24 ,  C12N2501/115 ,  C12N2501/11 ,  C12N2501/135

    Abstract: A large amount of cardiomyocyte spheroids is obtained from dissociated cardiomyocytes in a simple manner, in a short time, without using a special culture medium component, and without using a complicatedly-shaped container or a minute container. The problems can be solved by a method for producing cardiomyocyte spheroids, the method including allowing dissociated cardiomyocytes to flow under suspension conditions in a non-annular container to aggregate the cells. In addition, the problems can also be solved by a method for producing cardiomyocyte spheroids, in which the dissociated cardiomyocytes have a history of stabilization culture after thawing.

    FORMYL GROUP-CONTAINING POROUS SUPPORT, ADSORBENT USING SAME, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING THE ADSORBENT
    7.
    发明申请
    FORMYL GROUP-CONTAINING POROUS SUPPORT, ADSORBENT USING SAME, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING THE ADSORBENT 审中-公开
    含甲基基团的多孔支持物，使用其的吸附剂，其生产方法和生产吸附剂的方法

    公开(公告)号：US20150361185A1

    公开(公告)日：2015-12-17

    申请号：US14832819

    申请日：2015-08-21

    Applicant: KANEKA CORPORATION ,  JNC CORPORATION

    Inventor： Yoshikazu KAWAI ,  Hiroaki KAWASAKI ,  Naomi KAWAHARA

    IPC: C08B37/00

    CPC classification number: C08B37/00 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3229 ,  B01J20/3244 ,  B01J20/3248

    Abstract: The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to transform the part of the spacer into a formyl group; wherein the formyl group content in the porous particle after introduction of the spacer is not more than 3 μmol per 1 mL of the porous particle. Also, the present invention relates to a method for producing an adsorbent, comprising the step of immobilizing an amino group-containing ligand on the formyl group-containing porous base matrix. According to the present invention, a formyl-group containing porous base matrix and an adsorbent produced from the porous base matrix of which adsorption amount is high and which is has high strength and of which ligand is difficult to be leaked are provided.

    Abstract translation: 本发明涉及一种含有甲酰基的多孔基质基质的制造方法，包括以下步骤：在含甲酰基的多孔质粒子中引入间隔物; 然后用高碘酸和/或高碘酸盐氧化间隔物，以将部分间隔物转化成甲酰基; 其中间隔物引入后的多孔质粒中的甲酰基含量相对于1mL多孔质粒不超过3μmol。 此外，本发明涉及一种吸附剂的制造方法，其特征在于，含有含氨基的配位体固定在含甲酰基的多孔质基体上的工序。 根据本发明，提供了含有甲酰基的多孔基质基质和由吸附量高，强度高，配体难以泄漏的多孔基质基质生成的吸附剂。

    ADSORBENT
    8.
    发明申请
    ADSORBENT 审中-公开
    吸引力

    公开(公告)号：US20150297820A1

    公开(公告)日：2015-10-22

    申请号：US14427247

    申请日：2013-09-09

    Applicant: KANEKA CORPORATION

    Inventor： Yoshikazu KAWAI ,  Ken-ichiro MORIO ,  Fuminori KONIKE ,  Kana WATANABE ,  Yasuyuki SUZUKI ,  Masaru HIRANO

    IPC: A61M1/36 ,  C08L1/02

    CPC classification number: A61M1/3679 ,  A61K9/1652 ,  C08B15/10 ,  C08B16/00 ,  C08J3/126 ,  C08J3/16 ,  C08J2301/02 ,  C08J2405/02 ,  C08J2489/00 ,  C08L1/02 ,  C08L5/02 ,  C08L89/00

    Abstract: The objective of the present invention is to obtain an adsorbent having high adsorption capacity and high strength comprising porous cellulose beads obtained without using an auxiliary material which is highly toxic and corrosive and without a cumbersome and industrially adverse step. The present invention is characterized by immobilizing a ligand onto porous cellulose beads obtained by mixing a cold alkaline aqueous solution and cellulose powder as a raw material to prepare a cellulose dispersion and bringing the cellulose dispersion into contact with a coagulating solvent.

    Abstract translation: 本发明的目的是获得具有高吸附能力和高强度的吸附剂，其包含多孔纤维素珠粒，而不使用高毒性和腐蚀性的辅助材料，并且没有麻烦和工业上不利的步骤。 本发明的特征在于将配体固定在通过混合冷碱水溶液和纤维素粉末作为原料而获得的多孔纤维素珠粒上，以制备纤维素分散体并使纤维素分散体与凝固溶剂接触。

    PRODUCTION METHOD FOR INDUCED PLURIPOTENT STEM CELLS
    9.
    发明申请
    PRODUCTION METHOD FOR INDUCED PLURIPOTENT STEM CELLS 有权

    公开(公告)号：US20250145965A1

    公开(公告)日：2025-05-08

    申请号：US18835550

    申请日：2023-02-02

    Applicant: RIKEN ,  KANEKA CORPORATION

    Inventor： Yohei HAYASHI ,  Mami TAKASAKI ,  Sho KAMBAYASHI ,  Yoshikazu KAWAI

    IPC: C12N5/074 ,  C12N15/86

    Abstract: To provide a method for producing induced pluripotent stem cells (iPS cells) that can initialize somatic cells without using feeder cells or a substrate. For production of iPS cells, the following steps are carried out: I. introducing an initialization gene into a somatic cell; and II. performing initialization and amplification culture of the cell into which the gene has been introduced, in a liquid medium comprising at least one of a protein kinase Cβ (PKCβ) inhibitor and a WNT inhibitor under a suspension culture condition.

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