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公开(公告)号：DE69120715T2
公开(公告)日：1996-11-28
申请号：DE69120715
申请日：1991-04-17
Applicant: KAO CORP
Inventor： HORI KIMIHIKO , SUZUKI YASUTO , MORIOKA TOMOKI , MORIWAKI SHIGERU , HIROTA OSAMU , TSUCHIYA SHUICHI , HASE TADASHI
Abstract: A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I), wherein R is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R is a hydroxyl group or an acyloxy group having 1-6 carbon atoms, R is a hydrogen atom or a lower alkyl group, or R and R may together form a lower alkylidenedioxy group, X and X may be the same or different and individually represents a hydrogen atom or a halogen atom, Y and Y may be the same or different and individually represents a methylene group or a sulfur atom, Z is a sulfur atom or an imino group, the wave line means that the configuration of R may be of either alpha or beta , and dotted line between the 1 and 2 position means that the bond may be the double bond. It has excellent anti-inflammatory, anti-allergic and anti-asthma activities with little side effects, and is useful for the prevention, cure, and treatment of on inflammation, allergic diseases, rheumatism, and the like.
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公开(公告)号：DE60329874D1
公开(公告)日：2009-12-17
申请号：DE60329874
申请日：2003-01-07
Applicant: KAO CORP
Inventor： TERAZAKI HIROYUKI , KASUGA FUMIKO , HIROTA OSAMU
IPC: A61K8/00 , A61Q5/02 , A61K8/34 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/40 , A61K8/42 , A61K8/46 , A61K8/73 , A61K8/89 , A61K8/891 , C08L83/04
Abstract: A hair cleansing composition comprises the following ingredients (A) to (D): (A) an anionic surfactant having a sulfate group, (B) a cationic guar gum, (C) an organic acid selected from a hydroxycarboxylic acid, a dicarboxylic acid or an aromatic carboxylic acid, and (D) a salt; and has a pH of from 1 to 4 when diluted 20-fold by weight with water. The hair cleansing composition has good foamability and high-lubricity foam quality upon washing and smooth touch upon rinsing, and is excellent in the luster and softness of hair after drying and also superb in stability.
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公开(公告)号：DE60318132T2
公开(公告)日：2008-12-04
申请号：DE60318132
申请日：2003-01-07
Applicant: KAO CORP
Inventor： TERAZAKI HIROYUKI , KASUGA FUMIKO , HIROTA OSAMU
IPC: A61K8/00 , A61Q5/02 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/46 , A61K8/73 , A61K8/89 , A61K8/891 , A61Q5/12 , C08L83/04
Abstract: To provide a hair cleansing composition having good foamability and high-lubricity foam quality upon washing and smooth touch upon rinsing, and providing excellent feeling in use. A hair cleansing composition comprises the following ingredients (A) to (C): (A) an anionic surfactant having a sulfate group, (B) a higher alcohol having 10 to 14 carbon atoms, and (C) a cationic polymer, and has a pH of from 3 to 5.5 when diluted 20-fold by weight with water. The hair cleansing composition has good foamability and high-lubricity foam quality upon washing and smooth touch upon rinsing, and is excellent in use feeling.
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公开(公告)号：DE60318132D1
公开(公告)日：2008-01-31
申请号：DE60318132
申请日：2003-01-07
Applicant: KAO CORP
Inventor： TERAZAKI HIROYUKI , KASUGA FUMIKO , HIROTA OSAMU
IPC: A61K8/00 , A61Q5/02 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/46 , A61K8/73 , A61K8/89 , A61K8/891 , A61Q5/12 , C08L83/04
Abstract: To provide a hair cleansing composition having good foamability and high-lubricity foam quality upon washing and smooth touch upon rinsing, and providing excellent feeling in use. A hair cleansing composition comprises the following ingredients (A) to (C): (A) an anionic surfactant having a sulfate group, (B) a higher alcohol having 10 to 14 carbon atoms, and (C) a cationic polymer, and has a pH of from 3 to 5.5 when diluted 20-fold by weight with water. The hair cleansing composition has good foamability and high-lubricity foam quality upon washing and smooth touch upon rinsing, and is excellent in use feeling.
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公开(公告)号：DE69120715D1
公开(公告)日：1996-08-14
申请号：DE69120715
申请日：1991-04-17
Applicant: KAO CORP
Inventor： HORI KIMIHIKO , SUZUKI YASUTO , MORIOKA TOMOKI , MORIWAKI SHIGERU , HIROTA OSAMU , TSUCHIYA SHUICHI , HASE TADASHI
Abstract: A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I), wherein R is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R is a hydroxyl group or an acyloxy group having 1-6 carbon atoms, R is a hydrogen atom or a lower alkyl group, or R and R may together form a lower alkylidenedioxy group, X and X may be the same or different and individually represents a hydrogen atom or a halogen atom, Y and Y may be the same or different and individually represents a methylene group or a sulfur atom, Z is a sulfur atom or an imino group, the wave line means that the configuration of R may be of either alpha or beta , and dotted line between the 1 and 2 position means that the bond may be the double bond. It has excellent anti-inflammatory, anti-allergic and anti-asthma activities with little side effects, and is useful for the prevention, cure, and treatment of on inflammation, allergic diseases, rheumatism, and the like.
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Patent Agency Ranking
公开(公告)号：JPH0543435A
公开(公告)日：1993-02-23
申请号：JP20604591
申请日：1991-08-16
Applicant: KAO CORP
Inventor： HIROTA OSAMU , ABE YOSHIAKI
Abstract: PURPOSE:To obtain a shampoo composition, excellent in detergency and foaming power, having low irritancy, good in feeling of use due to no unsmoothness in washing and rinsing hair and improved in touch after washing. CONSTITUTION:A shampoo composition containing (A) an alkylsaccharide-based surfactant, (B) a sulfosuccinate-based surfactant and (C) a quaternary ammonium salt at a weight ratio of the ingredients (B)/(C) within the range of (100/1)-(2/1).
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公开(公告)号：JPH0543434A
公开(公告)日：1993-02-23
申请号：JP20527091
申请日：1991-08-15
Applicant: KAO CORP
Inventor： HIROTA OSAMU , ABE YOSHIAKI
Abstract: PURPOSE:To obtain a shampoo composition, excellent in detergency and foaming power, having low irritancy and good in feeling of use due to no unsmoothness in washing hair with hardly any damage to the hair. CONSTITUTION:A shampoo composition containing (a) 1-50wt.% alkylsaccharide- based surfactant and (b) 0.001-1wt.% polyethylene glycol having >=500000 average molecular weight.
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公开(公告)号：JPH0469395A
公开(公告)日：1992-03-04
申请号：JP17903690
申请日：1990-07-06
Applicant: KAO CORP
Inventor： HORI KIMIHIKO , MORIOKA TOMONORI , SUZUKI YASUTO , MORIWAKI SHIGERU , HIROTA OSAMU , TSUCHIYA SHUICHI
Abstract: NEW MATERIAL:A compound shown by formula I (R1 is OH or 1-6C acyloxy; R2 is H or lower alkyl; R3 is lower alkyl; X and Y are H or halogen; Z is O or S; wavy line is in alpha or beta steric configuration; broken line between the 1 and 2 positions may be double bond). EXAMPLE:21-(3-Ethoxy-1,3-dioxopropoxy)-9-fluoro-11,17-dihydroxy--16beta- methylpregna-1,4-diene-3,20-dione. USE:An antiinflammatory drug showing highly antiinflammatory effects with an extremely small amount. PREPARATION:A steroid compound shown by formula II is allowed to react with 1-3 equivalents, based on the compound, of an acid chloride of malonic acid monoester shown by formula III in the presence of a basic catalyst (e.g. pyridine or triethylamine) in a solvent (e.g. methylene chloride) at -20 to 10 deg.C for 1-2 hours while stirring.
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公开(公告)号：JPH03264520A
公开(公告)日：1991-11-25
申请号：JP6391290
申请日：1990-03-14
Applicant: KAO CORP
Inventor： YOROZU HIDENORI , HIROTA OSAMU , TSUCHIYA SHUICHI
IPC: A61K8/00 , A61K8/31 , A61K8/37 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q19/00 , A61Q19/10 , C08L83/04 , C11D7/40
Abstract: PURPOSE:To provide the title composition high in the cleaning effect on dried feces, thus high in protective effect and pruritusmitigating effect of the site around the anus, comprising vegetable oil, etc., silicone oil and buffer solution capable of adjusting the pH value of the skin at specified level. CONSTITUTION:The objective composition comprising (A) 5-50wt.% of at least one kind of oil selected from (1) vegetable oils such as jojoba oil, squalene and glycerin-tri-2-ethylhexanoate, (2) animal oils and (3) synthetic oils, (B) 5-50wt.% of a silicone oil such as straight chain or cyclic dimethylsilicone
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公开(公告)号：JPH01313419A
公开(公告)日：1989-12-18
申请号：JP14639488
申请日：1988-06-14
Applicant: KAO CORP
Inventor： HIROTA OSAMU , TSUCHIYA SHUICHI , FURUKAWA MIKIO
Abstract: PURPOSE:To obtain the subject composition having stable and good releasability of drug independent of physical properties of oily base agent or effective component, thus having high utilization of effective component by uniformly dispersing water-soluble polymer solid insoluble in oil base agent in which effective component is dispersed into oil base agent. CONSTITUTION:At least one effective component is dispersed into (1/10)-1000 times wt., preferably (1/4)-100 times wt. water-soluble polymer solid insoluble in oily base agent, preferably in amorphous state, then resultant composition is uniformly dispersed in oily base agent to obtain a preparation composition for administration to rectum having said effect. In said composition, releasability of effective component from preparation is independent of properties of effective component or properties of oily base agent and dependent of only properties of used water-soluble polymer, then excellent releasability is exhibited independently of properties various effective components having different properties.
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