公开(公告)号：JPS60224638A

公开(公告)日：1985-11-09

申请号：JP8246484

申请日：1984-04-23

Applicant: KAO CORP

Inventor： KAMIYA TETSUROU ,  INOUE TAKESHI ,  YOROZU HIDENORI ,  EGUCHI YASUTERU ,  TSUJII KAORU

IPC: A61K9/08 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K9/70 ,  A61K47/08 ,  A61K47/10

Abstract: PURPOSE:An external drug, obtained by incorporating a percutaneous absorption promoter containing an ether compound of a specific glycerol or polyglycerol with an alcohol in a base, and capable of remarkably increasing the percutaneous absorbability of a drug effect component. CONSTITUTION:A percutaneous absorption promoter containing an ether compound of glycerol or polyglycerol with an alcohol expressed by formula I or II(R1-R4 are H, 1-24C saturated or unsaturated straight chain or branched chain aliphatic hydrocarbon, etc.; n R4s may be the same or different except when all R1-R4 are H; n is an integer 0-60) as an active component is contained in a base to enhance the percutaneous absorbability of an external drug. The amount of the promoter to be added is preferably 0.01-5wt% based on the total amount of the external drug. In use thereof as a base, the amount of the promoter to be incorporated may be >=10wt%. The promoter can be formulated in either one of hydrophilic and hydrophobic bases, and a drug effect component sparingly soluble in water can be dissolved in the hydrophilic base in a high concentration.

公开(公告)号：JPS60199807A

公开(公告)日：1985-10-09

申请号：JP5507984

申请日：1984-03-22

Applicant: KAO CORP

Inventor： HARA KENJI ,  FUTAMI TAKAHIRO ,  KAMIYA TETSUROU

IPC: A61K8/96 ,  A61K8/97 ,  A61K36/23 ,  A61Q19/00

Abstract: PURPOSE:A humectant, consisting of an extract, extracted from a plant of the family Umbelliferae known as a Chinese medicine or raw material for popular medicines from old times, and having a given molecular weight or below, and useful for skin cosmetics. CONSTITUTION:A humectant, obtained by extracting a plant of the family Umbelliferae such as Cnidium officinale, Angelica dahurica, Angelica acutiloba Kitagawa, Notopterygium incisium, Bupleurum falcatum L., Peucedanum praeruptorum Dunn, Ligusticum sinense Oliv. or Cnidium monnieri Cuss. in a raw or dried state with ethanol in 50-80% concentration, and having