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    THERAPEUTIC AGENT FOR HYPERCHOLESTEREMIA
    1.
    发明专利
    THERAPEUTIC AGENT FOR HYPERCHOLESTEREMIA 失效

    公开(公告)号：JPH07188038A

    公开(公告)日：1995-07-25

    申请号：JP33578393

    申请日：1993-12-28

    Applicant: KAO CORP

    Inventor： SAKAMOTO SUSUMU ,  SUZUKI ATSUSHI ,  HORI KIMIHIKO ,  IMOKAWA GENJI

    IPC: C12P19/04 ,  A61K31/715 ,  A61K36/18 ,  A61P3/06 ,  C12N5/00 ,  C12R1/91 ,  A61K35/78 ,  A61K31/725

    Abstract: PURPOSE:To obtain a therapeutic agent for hypercholesteremia which contains, as an active ingredient, an acidic heteropoly-saccharide which is extracellularly secreted by the callus induced from a plant belonging to the genus Polianthes and has hypocholesteremic action with high safety and manifests the effect with less dosage than that in natural polysaccharides. CONSTITUTION:This therapeutic agent contains an acidic heteropoly-saccharide which is extracellularly secreted by the callus induced from a plant belonging to the genus Polianthes such as tuberose, preferably composed of arabinose, galactose, mannose, glucuronic acid and xylose as constituents (the formula gives the linking pattern and the constitution proportion, while the molecular weight is 1X10 to 2X10 ), as an active ingredient.

    NEW GENE
    2.
    发明专利
    NEW GENE 失效

    公开(公告)号：JPH03228678A

    公开(公告)日：1991-10-09

    申请号：JP20794689

    申请日：1989-08-14

    Applicant: KAO CORP

    Inventor： OSAWA TOSHIAKI ,  SAKAMOTO SUSUMU ,  YOSHIZUKA NAONOBU

    IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K7/06 ,  C07K14/00 ,  C07K14/52 ,  C12N15/19 ,  C12P21/02

    Abstract: PURPOSE:To obtain a precursor of human macrophage chemotactic factor in high purity and large quantities by preparing a now gene from mRNA derived from a human peripheral blood lymphocyte, human T lymphocyte hybridoma and/or human T lymphocyte based established cell. CONSTITUTION:A normal human peripheral blood lymphocyte, human T human lymphocyte established cell and/or cloning strain is cultured and a cell capable of synthesizing a protein having an amino sequence having a human macrophage chemotactic factor(MCF) or partial structure thereof is cultured therefrom and a fraction containing mRNA is separated from total RNA fraction obtained by grinding the resultant cell and extracting from the ground cell. Then cDNA prepared using the above-mentioned mRNA as template and successively using a reverse transcription enzyme, reverse transcriptase and ribonuclease and DNA synthetic enzyme is integrated into a vector and the resultant recombinant is introduced into a host to provide cDNA library. The cDNA coding a human MCF precursor protein is cloned from the above-mentioned cDNA library by a plaque hybridization method to provide the cloned DNA capable of coding a human MCF precursor protein and having a base sequence expressed by the formula.

    CURING PROMOTER FOR WOUND
    4.
    发明专利
    CURING PROMOTER FOR WOUND 失效

    公开(公告)号：JPH06329546A

    公开(公告)日：1994-11-29

    申请号：JP12268793

    申请日：1993-05-25

    Applicant: KAO CORP

    Inventor： SAKAMOTO SUSUMU ,  SUZUKI ATSUSHI ,  OTSUJI KAZUYA ,  TSUCHIYA SHUICHI

    IPC: A61K36/18 ,  A61K31/715 ,  A61P17/00 ,  A61P43/00 ,  C08B37/00 ,  A61K35/78 ,  A61K31/725

    Abstract: PURPOSE:To obtain a curing promoter for wounds, capable of promoting treatment of the wounds causing a rupture in the skin or mucous membrane, excellent in biocompatibility and having high safety. CONSTITUTION:The curing promoter for wounds contains acidic heteropolysaccharides extracellularly secreted by a callus induced from a plant which belongs to the genus Polianthes (e.g. Polianthes tuverosa L.) as an active ingredient. The acidic heteropolysaccharides contain arabinose, mannose, galactose, glucuronic acid and xylose as constituent saccharides and the binding manner and constituent ratio thereof are expressed by the formula. The acidic heteropolysaccharides have 1X10 to 2X10 molecular weight and physicochemical properties such as solubility: soluble in water and insoluble in ethanol, ether and acetone; color reaction: positive to the allethrone reaction and carbazole reaction and negative to the Elson-Morgan reaction and specific rotatory power: [alpha] D=0 to +20 deg. (C=1.0, aqueous solution).

    PREVENTIVE AND REMEDY FOR THROMBOSIS
    6.
    发明专利
    PREVENTIVE AND REMEDY FOR THROMBOSIS 失效

    公开(公告)号：JPS6434921A

    公开(公告)日：1989-02-06

    申请号：JP19076987

    申请日：1987-07-30

    Applicant: KAO CORP

    Inventor： OKAZAKI KIYOTAKA ,  SAKAMOTO SUSUMU ,  FURUKAWA MIKIO

    IPC: A61K38/46 ,  A61P7/02

    Abstract: PURPOSE:To provide an easily administrable preventive and remedy for thrombosis, exhibiting excellent effect even by oral administration and having low toxicity and side effect, by using a protease free from plasminogen activator activity as an active component. CONSTITUTION:A protease free from plasminogen activator activity, preferably a protease having an optimum pH of 5-9 (e.g. chymotrypsin, subtilicin, thermolysin or papain) is used as an active component. The compound is preferably administered at a rate of 150-300 Azocoll unit for adult in one or several divided doses. It exhibits excellent anticoagulation and thrombolytic actions by oral administration.

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