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    DERMATOLOGIC PREPARATION
    3.
    发明公开
    DERMATOLOGIC PREPARATION 失效
    皮肤病制剂

    公开(公告)号：EP0755671A4

    公开(公告)日：1997-04-09

    申请号：EP95914561

    申请日：1995-04-11

    Applicant: KAO CORP

    Inventor： YAMAGUCHI MASAKAZU ,  KAWAMATA AKIRA ,  OHSU HIROYUKI ,  TAKEMA YOSHINORI ,  IMOKAWA GENJI

    IPC: A61K8/49 ,  A61Q17/04 ,  A61K7/48 ,  A61K7/00

    CPC classification number: A61Q17/04 ,  A61K8/4973 ,  A61Q19/08

    Abstract: A dermatologic preparation containing a furan derivative represented by general formula (1) as the active ingredient, wherein X represents optionally substituted furan, benzofuran or isobenzofuran residue; and R and R represent each C1-C8 linear, branched or cyclic alkyl which may be substituted by X-CH2-N(R )- (wherein R represents C1-C6 linear or branched alkyl; and X is as defined above), or R and R together with the adjacent nitrogen atom may form a heterocycle which may be substituted by X-CH2- (wherein X is as defined above). The preparation is excellent in the effect of inhibiting wrinkling due to exposure to ultraviolet radiations, especially UV-B, and hence useful for the inhibition of wrinkling.

    6.
    发明专利
    未知

    公开(公告)号：DE69209513T2

    公开(公告)日：1996-09-12

    申请号：DE69209513

    申请日：1992-09-22

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  NAGAI MINORU ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI ,  TAKEMA YOSHINORI ,  SAKAINO YUKIKO ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU

    IPC: A61K8/41 ,  A61K31/13 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48

    Abstract: PCT No. PCT/JP92/01210 Sec. 371 Date Mar. 23, 1994 Sec. 102(e) Date Mar. 23, 1994 PCT Filed Sep. 22, 1992 PCT Pub. No. WO93/05763 PCT Pub. Date Apr. 1, 1993A composition for external skin care comprising an amine derivative represented by the following formula (1), (1) wherein R1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R2, R3, R4, R5 and R6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.

    9.
    发明专利
    未知

    公开(公告)号：DE3581815D1

    公开(公告)日：1991-04-04

    申请号：DE3581815

    申请日：1985-03-05

    Applicant: KAO CORP

    Inventor： NAKAMURA KOICHI ,  HATTORI MICHIHIRO ,  TAMURA TADASHI ,  TEJIMA TOHRU ,  TAKAISHI NOATAKE ,  IMOKAWA GENJI

    IPC: A61K8/00 ,  A61K8/33 ,  A61K8/36 ,  A61K8/368 ,  A61K8/37 ,  A61K8/39 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/08 ,  C07C65/34 ,  C07C65/40 ,  C09K3/00 ,  A61K7/44

    Abstract: A composition for application to the skin to protect the skin from the long wavelength ultraviolet ray comprises a dibenzoylmethane derivative of the following general formulain which X represents a hydrogen atom, a monovalent metal cation, an organic cation, a linear or branched alkyl group having from 1 to 24 carbon atoms, or a polyoxyalkylene oxide having 2 or 3 carbon atoms, each Y and each Z independently represent a hydroxyl group, a linear or branched alkyl group having from 1 to 24 carbon atoms, or an alkoxy group having from 1 to 24 carbon atoms, or a polyoxyalkylene oxide group having from 2 to 3 carbon atoms, and m and n are independently an integer of from 0 to 3.The composition is adjustable so as to have an optimum HLB balance and has good compatibility with various cosmetic bases. Further, it does not irritate the skin, is difficult to be percutaneously absorbed and shows continued skin-protecting effects.

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