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    COOLING AGENT AND TRPM8 ACTIVATOR
    3.
    发明公开
    COOLING AGENT AND TRPM8 ACTIVATOR 有权
    KÜHLMITTELUND TRPM8-AKTIVATOR

    公开(公告)号：EP2787051A4

    公开(公告)日：2015-07-15

    申请号：EP12853310

    申请日：2012-11-19

    Applicant: KAO CORP

    Inventor： SHIRAI TOMOHIRO ,  KUSUOKU HIROSHI ,  SAKASAI MITSUYOSHI ,  KUMIHASHI KENTARO

    IPC: C09K3/00 ,  A61K8/34 ,  A61K47/08 ,  A61Q11/00 ,  C07C43/23

    CPC classification number: C07C43/23 ,  A61K8/33 ,  A61K8/347 ,  A61K2201/054 ,  A61K2800/10 ,  A61K2800/244 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/00

    Abstract: Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein R 1 represents a hydrogen atom; R 2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R 3 represents a hydrogen atom or a hydroxyl group; R 4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R 5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

    Abstract translation: 提供具有优异的TRPM8活化作用的冷却剂，TRPM8活化剂，赋予冷却感的方法，以及用于赋予冷却感的新型化合物。 公开了一种冷却剂，其包含作为活性成分的由下式（1）表示的化合物：其中R 1表示氢原子; R 2表示氢原子，羟基或具有1至3个碳原子的烷氧基; R 3表示氢原子或羟基; R 4表示氢原子，碳原子数1〜6的烷基，碳原子数2〜6的烯基，碳原子数1〜3的烷氧基。 R 5表示氢原子或碳原子数为1〜3的烷氧基; R 6表示氢原子，羟基，碳原子数1〜14的烷氧基，碳数2〜12的烷氧基烷氧基，碳原子数3〜12的环烷氧基，芳氧基 具有6至12个碳原子，总共具有7至14个碳原子的芳烷氧基或总共具有2至12个碳原子的烷酰氧基。

    NFAT SIGNAL INHIBITOR AND HAIR-GROWING AGENT
    4.
    发明公开
    NFAT SIGNAL INHIBITOR AND HAIR-GROWING AGENT 审中-公开
    NFAT信号抑制剂和毛发生长基金

    公开(公告)号：EP2348025A4

    公开(公告)日：2012-04-04

    申请号：EP09821803

    申请日：2009-10-21

    Applicant: KAO CORP

    Inventor： SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NAGASAWA AZUMI

    IPC: C07D493/04 ,  A61K8/49 ,  A61K31/352 ,  A61Q7/00

    CPC classification number: A61K31/352 ,  A61K8/498 ,  A61Q7/00 ,  C07D493/04

    Abstract: An NFAT signal inhibitor and the like are provided. An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R 1 and R 2 which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R 3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

    Fat accumulation inhibitor
    5.
    发明专利
    Fat accumulation inhibitor 审中-公开
    FAT累积抑制剂

    公开(公告)号：JP2014040487A

    公开(公告)日：2014-03-06

    申请号：JP2013249747

    申请日：2013-12-03

    Applicant: Kao Corp ,  花王株式会社

    Inventor： MORI SHINOBU ,  TAKIZAWA MINORU ,  SAKASAI MITSUYOSHI

    IPC: A61K36/18 ,  A61K8/97 ,  A61K36/24 ,  A61P3/04 ,  A61P3/06 ,  A61P17/00 ,  A61Q19/06 ,  A61Q19/10

    Abstract: PROBLEM TO BE SOLVED: To provide a fat accumulation inhibitor which is effective for the prevention of obesity, the suppression of cellulite, and the like.SOLUTION: The fat accumulation inhibitor includes, as active ingredients, one or more plants selected from plants belonging to families Saururaceae Saururus, Apocynaceae Apocynum, and Cornaceae Cornus Benthamidia, or an extract thereof.

    Abstract translation: 要解决的问题：提供一种对预防肥胖，抑制脂肪团等有效的脂肪蓄积抑制剂。解脂：脂肪蓄积抑制剂包括作为活性成分的一种或多种选自属于 家S科Saururus，Apocynaceae Apocynum和Cornaceae Cornus Benthamidia，或其提取物。

    &bgr;-GLUCURONIDASE INHIBITOR
    6.
    发明专利
    &bgr;-GLUCURONIDASE INHIBITOR 审中-公开

    公开(公告)号：JP2013252451A

    公开(公告)日：2013-12-19

    申请号：JP2013177700

    申请日：2013-08-29

    Applicant: KAO CORP

    Inventor： SAKASAI MITSUYOSHI ,  MORI ICHIRO

    IPC: A61L9/01 ,  A61F13/15 ,  A61F13/49 ,  A61L15/00

    Abstract: PROBLEM TO BE SOLVED: To provide an agent for persistently restraining generation of malodor derived from urine by clarifying a malodor component more highly contributing to urine odor than ammonia in a living environment and by inhibiting enzyme related to the generation.SOLUTION: There are provided a new &bgr;-glucuronidase inhibitor comprising oak (myrobalan) or its extract. An environmental hygiene product and a sanitary product contain the &bgr;-glucuronidase inhibitor. There are also provided a composition for restraining generation of urine odor and a method of restraining the generation of urine odor using the &bgr;-glucuronidase inhibitor.

    Composition for restraining uraroma formation
    7.
    发明专利
    Composition for restraining uraroma formation 审中-公开
    用于限制URAROMA形成的组合物

    公开(公告)号：JP2010246905A

    公开(公告)日：2010-11-04

    申请号：JP2010068105

    申请日：2010-03-24

    Applicant: Kao Corp ,  花王株式会社

    Inventor： MORI ICHIRO ,  SAKASAI MITSUYOSHI ,  ISHIDA HIROHIKO

    IPC: A61L9/01 ,  A01K1/015 ,  A01K23/00 ,  A61L9/14

    Abstract: PROBLEM TO BE SOLVED: To provide an agent capable of continuously restraining the formation of malodor originating in urine by clarifying a malodor component higher in contribution to uraroma than ammonia in a living environment and blocking an enzyme related to the formation.
    SOLUTION: A uraroma formation inhibitor containing a stem extract of Akebia quinata as an active component, and a uraroma formation restraining composition containing the stem extract of Akebia quinata and 0.08-6 wt.% of surfactant, are provided, and a method is provided for restraining uraroma formation by applying the uraroma formation inhibitor or the uraroma formation restraining composition before urine sticks to an object or before urine dries after sticking.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种能够通过在生活环境中澄清与尿素相比高于氨的恶臭成分，并且阻断与形成有关的酶，从而能够连续地抑制来自尿液的恶臭的形成。 解决方案：提供含有作为活性成分的quin藜的茎提取物和含有蜱螨的茎提取物和0.08-6重量％的表面活性剂的尿素形成抑制组合物的尿囊形成抑制剂， 提供用于通过在尿液粘贴到物体之前或在尿液干燥之后施加尿素形成抑制剂或尿红质形成抑制组合物来抑制尿路形成。 版权所有（C）2011，JPO＆INPIT

    Potential-dependent cation channel inhibitor
    8.
    发明专利
    Potential-dependent cation channel inhibitor 审中-公开
    潜在依赖性通道抑制剂

    公开(公告)号：JP2011201818A

    公开(公告)日：2011-10-13

    申请号：JP2010071645

    申请日：2010-03-26

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKASAI MITSUYOSHI ,  TAKATOKU HIROKO ,  KUMIHASHI KENTARO

    IPC: A61K31/343 ,  A61P25/02 ,  A61P43/00 ,  C07D307/88

    Abstract: PROBLEM TO BE SOLVED: To provide an excellent potential-dependent cation channel inhibitor.SOLUTION: The potential-dependent cation channel inhibitor comprises a phthalide analog represented by formula (1) [wherein, ring A is a saturated, partially unsaturated or completely unsaturated six-membered ring; X is C=CH-R(Ris 1-12C alkyl), CRR(Ris 1-12C alkyl; Ris a hydrogen atom or 1-5C alkyl); Rand Rare each, same or different, a hydrogen atom or hydroxy] as an active ingredient.

    Abstract translation: 要解决的问题：提供优异的电位依赖性阳离子通道抑制剂。溶液：电位依赖性阳离子通道抑制剂包含由式（1）表示的苯并呋喃类似物[其中，环A是饱和的，部分不饱和的或完全不饱和的六 记忆环 X是C = CH-R（R 1-12C烷基），CRR（R 1-12C烷基; R是氢原子或1-5C烷基）; 兰德稀有，相同或不同，氢原子或羟基]作为活性成分。

    Fat accumulation inhibitor
    9.
    发明专利
    Fat accumulation inhibitor 审中-公开
    FAT累积抑制剂

    公开(公告)号：JP2011126824A

    公开(公告)日：2011-06-30

    申请号：JP2009287576

    申请日：2009-12-18

    Applicant: Kao Corp ,  花王株式会社

    Inventor： MORI SHINOBU ,  TAKIZAWA MINORU ,  SAKASAI MITSUYOSHI

    IPC: A61K36/18 ,  A61K8/97 ,  A61P3/04 ,  A61P17/00 ,  A61Q19/06 ,  A61Q19/10

    Abstract: PROBLEM TO BE SOLVED: To provide a fat accumulation inhibitor derived from a plant which is effective in the prevention of obesity, the suppression of cellulite, and the like.
    SOLUTION: The fat accumulation inhibitor includes, as active ingredients, one or more plants selected from plants belonging to families Saururaceae Saururus, Apocynaceae Apocynum, and Cornaceae Cornus Benthamidia, or an extract thereof. The plant belonging to family Saururaceae Saururus is preferably Saururus chinensis; the plant belonging to family Apocynaceae Apocynum is preferably black indian hemp; and the plant belonging to family Cornaceae Cornus Benthamidia is preferably Benthamidia florida. The fat accumulation inhibitor is preferably used as skin care preparations or bath salts.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：提供一种有效预防肥胖，抑制脂肪团等的植物来源的脂肪蓄积抑制剂。 解决方案：脂肪蓄积抑制剂包括作为活性成分的一种或多种植物，其选自属于禾本科禾本科（Saururaceae Saururus），爪哇爪螨（Apocynaceae Apocynum）和芸苔科跖草（Benthamidia）的植物，或其提取物。 属于金枪鱼科（Saururaceae Saururus）的植物优选是中华龙虾; 属于Apocynaceae Apocynum的植物优选为黑印度大麻; 并且属于家ace科（Cornaceae Cornus Benthamidia）的植物优选为花本甲酸（Benthamidia florida）。 脂肪蓄积抑制剂优选用作护肤制剂或浴盐。 版权所有（C）2011，JPO＆INPIT

    β-GLUCURONIDASE INHIBITOR
    10.
    发明专利
    β-GLUCURONIDASE INHIBITOR 审中-公开
    β-GLUCURONIDASE抑制剂

    公开(公告)号：JP2010220641A

    公开(公告)日：2010-10-07

    申请号：JP2009067944

    申请日：2009-03-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKASAI MITSUYOSHI ,  MORI ICHIRO

    IPC: A61L9/01 ,  A61F13/15 ,  A61F13/49 ,  A61K8/97 ,  A61Q15/00 ,  A61Q19/10 ,  C12N9/99

    Abstract: PROBLEM TO BE SOLVED: To provide an agent for persistently restraining the generation of malodor derived from urine by making clear malodor component more highly contributing urine odor than ammonia in a living environment and inhibiting enzyme related to the generation.
    SOLUTION: New β-glucuronidase inhibitor is selected from creeping saxifrage, Damask rose, uva ursi, lianous Saururaceae, Henna (colorless), Rhododendron dauricum, tree peony and so on and extracts thereof. An environmental hygienics product and a sanitary product contain the β-glucuronidase inhibitor. A composition for restraining the generation of urine odor and a method of restraining the generation of urine odor use the β-glucuronidase inhibitor.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种用于通过在生活环境中比氨更明显地产生尿气味，并且抑制与生成相关的酶，来持续地抑制来自尿的恶臭的产生的代理。 解决方案：新型β-葡萄糖苷酸酶抑制剂选自匍匐，ask，玫瑰，紫罗兰，无花果，杜鹃花，树牡丹等。 环境卫生用品和卫生用品含有β-葡糖醛酸糖苷酶抑制剂。 用于抑制尿臭的产生的组合物和抑制尿臭的产生的方法使用β-葡糖醛酸糖苷酶抑制剂。 版权所有（C）2011，JPO＆INPIT

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