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    NFAT SIGNAL INHIBITOR AND HAIR-GROWING AGENT
    3.
    发明公开
    NFAT SIGNAL INHIBITOR AND HAIR-GROWING AGENT 审中-公开
    NFAT信号抑制剂和毛发生长基金

    公开(公告)号：EP2348025A4

    公开(公告)日：2012-04-04

    申请号：EP09821803

    申请日：2009-10-21

    Applicant: KAO CORP

    Inventor： SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NAGASAWA AZUMI

    IPC: C07D493/04 ,  A61K8/49 ,  A61K31/352 ,  A61Q7/00

    CPC classification number: A61K31/352 ,  A61K8/498 ,  A61Q7/00 ,  C07D493/04

    Abstract: An NFAT signal inhibitor and the like are provided. An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), R 1 and R 2 which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), R 3 represents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

    Hair growing agent
    4.
    发明专利
    Hair growing agent 有权
    头发生长剂

    公开(公告)号：JP2010100536A

    公开(公告)日：2010-05-06

    申请号：JP2008271069

    申请日：2008-10-21

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NAGASAWA AZUMI

    IPC: A61K8/49 ,  A61K31/352 ,  A61P17/14 ,  A61Q7/00 ,  C07D493/04

    Abstract: PROBLEM TO BE SOLVED: To identify an active ingredient showing hair-growing activity in a plant or a plant extract. SOLUTION: The active ingredient showing hair-growing activity is identified in an extract of Angelica atropurpurea. The active ingredient has an angular furocoumarin skeleton having a prescribed structure. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：鉴定在植物或植物提取物中显示毛发生长活性的活性成分。 解决方案：在当归提取物中鉴定显示毛发生长活性的活性成分。 活性成分具有规定结构的角状呋喃香豆素骨架。 版权所有（C）2010，JPO＆INPIT

    Catechin-containing beverage
    5.
    发明专利
    Catechin-containing beverage 有权
    含钙饮料

    公开(公告)号：JP2003081825A

    公开(公告)日：2003-03-19

    申请号：JP2001271804

    申请日：2001-09-07

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SUZUKI JUNKO ,  MURASE TAKATOSHI ,  NAGASAWA AZUMI ,  HASE TADASHI ,  TOKIMITSU ICHIRO

    IPC: A23L2/38 ,  A23F3/16 ,  A23L2/52 ,  A61K9/08 ,  A61K31/353 ,  A61P3/10 ,  A61P43/00 ,  C07D311/62

    Abstract: PROBLEM TO BE SOLVED: To obtain a GLUT4 expression promoter and a bottled beverage containing the same, which control a blood sugar level by rapidly taking absorbed glucose in blood in cells not by blood sugar control by sucrose absorption suppression such as digestive enzyme inhibition of glucide and transportation route inhibition from the intestinal tract, can suppress a rapid rise of blood sugar after taking sugar even without taking the promoter or the beverage simultaneously with a meal and are useful for preventing and ameliorating diabetes. SOLUTION: This glucose transporter 4 expression promoter comprises catechins. This bottled beverage for preventing/ameliorating diabetes comprises dissolved catechins as nonpolymer constituents (A) non-epicatechin and (B) epicatechin in the ratio of component (A)/the component (B) (by weight) (A)/(B) of 0.25-9.0.

    Abstract translation: 要解决的问题：获得GLUT4表达启动子和含有该GLUT4表达启动子的瓶装饮料，通过蔗糖吸收抑制如消化酶抑制糖分，通过在不通过血糖控制的细胞中快速吸收血液中的血液而控制血糖水平 和肠道的运输途径抑制，即使不用餐时同时服用促进剂或饮料，也可以抑制服用糖后血糖的快速上升，并且可用于预防和改善糖尿病。 解决方案：该葡萄糖转运蛋白4表达启动子包含儿茶素。 用于预防/改善糖尿病的瓶装饮料包括作为非聚合物组分的溶解儿茶素类（A）非表儿茶素和（B）表儿茶素按组分（A）/组分（B）（按重量计）（A）/（B） 为0.25-9.0。

    Nfat signal inhibitor and nfat signal-inhibiting method
    6.
    发明专利
    Nfat signal inhibitor and nfat signal-inhibiting method 审中-公开
    NFAT信号抑制剂和NFAT信号抑制方法

    公开(公告)号：JP2013060460A

    公开(公告)日：2013-04-04

    申请号：JP2012274686

    申请日：2012-12-17

    Applicant: Kao Corp ,  花王株式会社

    Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU

    IPC: A61K36/23 ,  A61K8/97 ,  A61K36/28 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  A61Q19/00 ,  C12N9/16 ,  C12N9/99 ,  C12N15/09

    Abstract: PROBLEM TO BE SOLVED: To provide a new NFAT signal inhibitor capable of inhibiting an NFAT signal.SOLUTION: The NFAT signal inhibitor includes at least one selected from the group consisting of at least one plant selected from plant species listed in plant name columns of Table 1, the extract of the plant, and an ingredient contained in the extract, as an active ingredient. The NFAT signal inhibitor can be applied to various fields such as external preparations, pharmaceutical compositions, cosmetics and foods.

    Abstract translation: 要解决的问题：提供能够抑制NFAT信号的新的NFAT信号抑制剂。 解决方案：NFAT信号抑制剂包括选自至少一种选自表1的植物名称栏中列出的植物物种，植物提取物和提取物中所含的成分的植物中的至少一种， 作为活性成分。 NFAT信号抑制剂可用于各种领域，如外用制剂，药物组合物，化妆品和食品。 版权所有（C）2013，JPO＆INPIT

    DnaJC6 EXPRESSION INHIBITOR
    7.
    发明专利
    DnaJC6 EXPRESSION INHIBITOR 审中-公开
    DnaJC6表达抑制剂

    公开(公告)号：JP2012153660A

    公开(公告)日：2012-08-16

    申请号：JP2011014838

    申请日：2011-01-27

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ICHINOSE SUSUMU ,  NAGASAWA AZUMI

    IPC: A61K8/49 ,  A61K31/437 ,  A61P17/14 ,  A61Q7/02 ,  C07D471/04

    Abstract: PROBLEM TO BE SOLVED: To provide a DnaJC6 expression inhibitor.SOLUTION: The DnaJC6 expression inhibitor comprises a compound represented by formula (I) (where, in Rand R, either is hydrogen and the other is methoxy) or its salt as an active constituent.

    Abstract translation: 待解决的问题：提供DnaJC6表达抑制剂。 解决方案：DnaJC6表达抑制剂包含由式（I）表示的化合物（其中，在R 1 和R 2 ，或者是氢，另一个是甲氧基）或其盐作为活性成分。 版权所有（C）2012，JPO＆INPIT

    Nfat signal inhibitor and nfat signal-inhibiting method
    8.
    发明专利
    Nfat signal inhibitor and nfat signal-inhibiting method 审中-公开
    NFAT信号抑制剂和NFAT信号抑制方法

    公开(公告)号：JP2010013403A

    公开(公告)日：2010-01-21

    申请号：JP2008175394

    申请日：2008-07-04

    Applicant: Kao Corp ,  花王株式会社

    Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU

    IPC: A61K36/28 ,  A61K31/343 ,  A61P9/00 ,  A61P19/08 ,  A61P37/06 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To provide a new NFAT (nuclear factor of activated T cells) signal inhibitor, and to provide an NFAT signal-inhibiting method by using the inhibitor.
    SOLUTION: The NFAT signal inhibitor contains Tanacetum parthenium, an extract of the Tanacetum parthenium or parthenolide.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供新的NFAT（活化T细胞的核因子）信号抑制剂，并通过使用抑制剂提供NFAT信号抑制方法。 解决方案：NFAT信号抑制剂含有Tanacetum铼，Tanacetum铼或Parthenolide的提取物。 版权所有（C）2010，JPO＆INPIT

    Hair tonic
    9.
    发明专利
    Hair tonic 审中-公开
    头发TONIC

    公开(公告)号：JP2013193985A

    公开(公告)日：2013-09-30

    申请号：JP2012062272

    申请日：2012-03-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SAKAGUCHI DAISHI ,  NAGASAWA AZUMI ,  WATANABE MANABU

    IPC: A61K8/97 ,  A61K36/18 ,  A61K36/23 ,  A61P17/14 ,  A61P43/00 ,  A61Q7/00 ,  C12N15/09

    Abstract: PROBLEM TO BE SOLVED: To provide a hair tonic that promotes hair growth and hair-fostering and is effective for various kinds of alopecia.SOLUTION: There are provided a hair tonic that includes as an effective ingredient a plant selected from Anthriscus sylvestris Hoffm. and Crinum asiaticum L.var. sinicum Bak. or an extract thereof, and an agent for suppressing DACH1 expression or suppressing functions of DACH1.

    Abstract translation: 要解决的问题：提供促进毛发生长和发育的发质，并且对各种秃发有效。解决方案：提供了一种滋补剂，其包含作为有效成分的选自Anthriscus sylvestris Hoffm的植物。 和Crinum asiaticum L.var。 sinicum Bak。 或其提取物，以及抑制DACH1表达或抑制DACH1功能的药剂。

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