公开(公告)号：EP0643035A4

公开(公告)日：1995-08-09

申请号：EP94910532

申请日：1994-03-25

Applicant: KAO CORP

Inventor： SAKAGUCHI AKIRA ,  KITAHARA TAKASHI ,  KOIZUMI KEIKO ,  SATO NORIKO B GURIMUHAITSU ,  HORI KIMIHIKO ,  SHINTA HIROYUKI C-KAO SHIROMI

IPC: C07C65/21 ,  C07C65/28 ,  C07C69/92 ,  C07C229/64 ,  C07C235/60 ,  C07C229/54 ,  C07C235/56 ,  C07C235/58 ,  C07C237/44

CPC classification number: C07C65/21 ,  C07C65/28 ,  C07C69/92 ,  C07C229/64 ,  C07C235/60

Abstract: A dermatologic preparation containing at least one of the benzoic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, having a sufficient effect of inhibiting sebum secretion and being free from side effects, thus being safe for the human body, wherein R represents -OH, -OR or -NHR ; R represents hydrogen, lower alkyl or lower alkoxy; R represents -OR or (II); R represents alkyl, alkenyl or hydroxyalkyl; R represents C4-C10 linear or branched, saturated or monounsaturated alkyl or cycloalkylalkyl; X represents -O- or -NH-; and n represents 1 or 2.