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公开(公告)号：CA1282338C
公开(公告)日：1991-04-02
申请号：CA540065
申请日：1987-06-18
Applicant: KAO CORP
Inventor： KITAHARA TAKASHI , YOSHIDA EISAKU , AKATSU MITSUHIRO , JOKURA YOJI , HATTORI MICHIHIRO , TAKAISHI NAOTAKE
IPC: A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/52 , A61P35/00 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61Q7/02 , A61Q15/00 , A61K35/78
Abstract: Disclosed is a 5.alpha.-reductase inhibitor comprising as an effective component an extract from leaves and/or pericarps of a walnut. The inhibitor exhibits highly potent 5.alpha.-reductase inhibiting activity and high safety, and is thus effective in curing and preventing diseases caused by testosterone, e.g. male-pattern alopecia, hirsutism, prostate cancer and the like.
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2.发明公开
公开(公告)号：EP1116712A4
公开(公告)日：2004-12-29
申请号：EP99943439
申请日：1999-09-21
Applicant: KAO CORP
Inventor： FUJIMORI TAKETOSHI , OHASHI YUKIHIRO , HIGUCHI KAZUHIKO , ISHIKAWA JUNKO , KITAHARA TAKASHI
IPC: A61K8/41 , A61K8/43 , A61K8/49 , A61Q19/08 , C07C217/28 , C07C219/06 , C07C229/12 , C07C233/18 , C07C279/08 , C07C291/04 , C07D263/24 , C07D295/088 , C07F9/09 , A61K31/13 , A61K31/40 , A61K31/495 , C07D263/20 , C07D295/08
CPC classification number: C07D295/088 , A61K8/41 , A61K8/43 , A61K8/4913 , A61Q19/08 , C07C217/28 , C07C219/06 , C07C229/12 , C07C233/18 , C07C279/08 , C07C291/04 , C07D263/24 , C07F9/091
Abstract: Amine derivatives represented by general formula (1) and preparations for external use containing the same which exhibit excellent effects of preventing the skin from aging, etc. In formula (1), R1 represents C¿1-30? hydrocarbyl optionally interrupted by an ether linkage (but excluding phenyl and benzyl); one of A and B represents (2), while the other represents -OR?4; R2 and R3¿ represent each H, amidino, alkanoyl, C¿1-20? hydrocarbyl, etc. and R?4 and R5¿ represent each H, phosphoryl, etc.
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公开(公告)号：EP0643035A4
公开(公告)日：1995-08-09
申请号：EP94910532
申请日：1994-03-25
Applicant: KAO CORP
Inventor： SAKAGUCHI AKIRA , KITAHARA TAKASHI , KOIZUMI KEIKO , SATO NORIKO B GURIMUHAITSU , HORI KIMIHIKO , SHINTA HIROYUKI C-KAO SHIROMI
IPC: C07C65/21 , C07C65/28 , C07C69/92 , C07C229/64 , C07C235/60 , C07C229/54 , C07C235/56 , C07C235/58 , C07C237/44
CPC classification number: C07C65/21 , C07C65/28 , C07C69/92 , C07C229/64 , C07C235/60
Abstract: A dermatologic preparation containing at least one of the benzoic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, having a sufficient effect of inhibiting sebum secretion and being free from side effects, thus being safe for the human body, wherein R represents -OH, -OR or -NHR ; R represents hydrogen, lower alkyl or lower alkoxy; R represents -OR or (II); R represents alkyl, alkenyl or hydroxyalkyl; R represents C4-C10 linear or branched, saturated or monounsaturated alkyl or cycloalkylalkyl; X represents -O- or -NH-; and n represents 1 or 2.
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公开(公告)号：DE60223472T2
公开(公告)日：2008-09-18
申请号：DE60223472
申请日：2002-09-18
Applicant: KAO CORP
Inventor： WAKISAKA ETSUJI , KITAHARA TAKASHI , TSUJI NAOKO , KUSUOKU HIROSHI
Abstract: The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the'hair body finer, thereby facilitating the removal of the hair from feet or arms.
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公开(公告)号：DE60223472D1
公开(公告)日：2007-12-27
申请号：DE60223472
申请日：2002-09-18
Applicant: KAO CORP
Inventor： WAKISAKA ETSUJI , KITAHARA TAKASHI , TSUJI NAOKO , KUSUOKU HIROSHI
Abstract: The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the'hair body finer, thereby facilitating the removal of the hair from feet or arms.
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Patent Agency Ranking
公开(公告)号：DE69420346T2
公开(公告)日：1999-12-30
申请号：DE69420346
申请日：1994-03-25
Applicant: KAO CORP
Inventor： SAKAGUCHI AKIRA , KITAHARA TAKASHI , KOIZUMI KEIKO , SATO NORIKO , HORI KIMIHIKO , SHINTA HIROYUKI
IPC: C07C65/21 , C07C65/28 , C07C69/92 , C07C229/64 , C07C235/60 , A61K31/19 , C07C235/56 , C07C235/58 , C07C237/44 , C07C229/54 , C07C65/26
Abstract: A dermatologic preparation containing at least one of the benzoic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, having a sufficient effect of inhibiting sebum secretion and being free from side effects, thus being safe for the human body, wherein R represents -OH, -OR or -NHR ; R represents hydrogen, lower alkyl or lower alkoxy; R represents -OR or (II); R represents alkyl, alkenyl or hydroxyalkyl; R represents C4-C10 linear or branched, saturated or monounsaturated alkyl or cycloalkylalkyl; X represents -O- or -NH-; and n represents 1 or 2.
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公开(公告)号：DE69420346D1
公开(公告)日：1999-10-07
申请号：DE69420346
申请日：1994-03-25
Applicant: KAO CORP
Inventor： SAKAGUCHI AKIRA , KITAHARA TAKASHI , KOIZUMI KEIKO , SATO NORIKO , HORI KIMIHIKO , SHINTA HIROYUKI
IPC: C07C65/21 , C07C65/28 , C07C69/92 , C07C229/64 , C07C235/60 , A61K31/19 , C07C235/56 , C07C235/58 , C07C237/44 , C07C229/54 , C07C65/26
Abstract: A dermatologic preparation containing at least one of the benzoic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, having a sufficient effect of inhibiting sebum secretion and being free from side effects, thus being safe for the human body, wherein R represents -OH, -OR or -NHR ; R represents hydrogen, lower alkyl or lower alkoxy; R represents -OR or (II); R represents alkyl, alkenyl or hydroxyalkyl; R represents C4-C10 linear or branched, saturated or monounsaturated alkyl or cycloalkylalkyl; X represents -O- or -NH-; and n represents 1 or 2.
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公开(公告)号：JP2010275323A
公开(公告)日：2010-12-09
申请号：JP2010204099
申请日：2010-09-13
Inventor： ISHIKAWA JUNKO , HIGUCHI KAZUHIKO , KITAHARA TAKASHI , KANAZAWA SATOSHI
Abstract: PROBLEM TO BE SOLVED: To provide a production promoter of cathepsin D associated with the abrasion of a horny substance at an epidermal cell. SOLUTION: The production promoter of the cathepsin D of the epidermal cell comprises an extract of a plant selected from Schizonepeta tenuifolia Briquet (var.japonica Kitagawa), Saussurea lappa Clarke, Pharbitis nil Choisy, Paeonia lactiflora Pallas, Camellia Sinensis(L) O.Kuntze, Haematoxylon campechianum L., Rehmannia glutinosa Liboschitz var. purpurea Makino or Rehmannia glutinosa Liboschitz, Thymus vulgaris L., Prunus persica Batsch or Prunus persica Batsch var. davidiana Maximowicz, Paeonia suffruticosa Andrews (Paeonia moutan Sims), Zingiber officinale Roscoe, Polygala tenuifolia Willdenow, Plantago asiatica L., Panax japonicum C.A.Meyer, Picrasma quassioides Bennet, Rhus javanica L., Betula platyphylla Sukatchev var.japonicum Hara, Coixlachryma-jobi L.var. ma-yuen Stapf, Hydrangea serrata Seringe var.thunbergii Sugimoto, Arnica Montana L., Arctium lappa L., Ganoclerma lucidum Karst. and Lilium candidum, and one or more kinds selected from lactoferrin. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供与表皮细胞上的角质物质的磨损相关的组织蛋白酶D的生产促进剂。 解决方案：表皮细胞的组织蛋白酶D的生产促进剂包括选自Schizonepeta tenuifolia Briquet（北美川awa），Saussurea lappa Clarke，Pharbitis nil Choisy，Paeonia lactiflora Pallas，Camellia Sinensis（L ）O.Kuntze，Haematoxylon campechianum L.，Rehmannia glutinosa Liboschitz var。 purpurea Makino或地黄枸杞Liboschitz，寻常百里树，Prunus persica Batsch或Prunus persica Batsch var。 栀子，芍药芍药（Paeonia moutan Sims），姜科，姜黄，Polygala tenuifolia Willdenow，Plantago asiatica L.，Panax japonicum CAMeyer，Picrasma quassioides Bennet，Rhus javanica L.，Betula platyphylla Sukatchev var.japonicum Hara，Coixlachryma-jobi L.var。 马en en f。。。。ii ii ii ii。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。 和百合百合，以及选自乳铁蛋白的一种或多种。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2007077171A
公开(公告)日：2007-03-29
申请号：JP2006346859
申请日：2006-12-25
Inventor： ISHIKAWA JUNKO , HIGUCHI KAZUHIKO , KITAHARA TAKASHI , KANAZAWA SATOSHI
IPC: A61K36/18 , A61K8/64 , A61K8/97 , A61K36/07 , A61K36/23 , A61K36/25 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/896 , A61K36/899 , A61K38/00 , A61P17/02 , A61P17/16 , A61P43/00 , A61Q19/00
Abstract: PROBLEM TO BE SOLVED: To provide a production promoter of cathepsin D associated with the abrasion of horny substance at an epidermal cell. SOLUTION: The production promoter of the cathepsin D by the epidermal cell comprises an extract of a plant selected from Schizonepeta tenuifolia Briquet (var.japonica Kitagawa), Saussurea lappa Clarke, Pharbitis nil Choisy, Paeonia lactiflora Pallas, Camellia Sinensis(L) O.Kuntze, Haematoxylon campechianum L., Rehmannia glutinosa Liboschitz var. purpurea Makino or Rehmannia glutinosa Liboschitz, Thymus vulgaris L., Prunus persica Batsch or Prunus persica Batsch var. davidiana Maximowicz, Paeonia suffruticosa Andrews (Paeonia moutan Sims), Zingiber officinale Roscoe, Polygala tenuifolia Willdenow, Plantago asiatica L., Panax japonicum C.A.Meyer, Picrasma quassioides Bennet, Rhus javanica L., Betula platyphylla Sukatchev var.japonicum Hara, Coixlachryma-jobi L.var. ma-yuen Stapf, Hydrangea serrata Seringe var.thunbergii Sugimoto, Arnica Montana L., Arctium lappa L., Ganoclerma lucidum Karst. and Lilium candidum, and one or more kinds selected from lactoferrin. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供与表皮细胞上的角质物质的磨损相关的组织蛋白酶D的生产促进剂。 解决方案：表皮细胞组织蛋白酶D的生产促进剂包括选自Schizonepeta tenuifolia Briquet（北美川awa），Saussurea lappa Clarke，Pharbitis nil Choisy，Paeonia lactiflora Pallas，Camellia Sinensis（L ）O.Kuntze，Haematoxylon campechianum L.，Rehmannia glutinosa Liboschitz var。 purpurea Makino或地黄枸杞Liboschitz，寻常百里树，Prunus persica Batsch或Prunus persica Batsch var。 栀子，芍药芍药（Paeonia moutan Sims），姜科，姜黄，Polygala tenuifolia Willdenow，Plantago asiatica L.，Panax japonicum CAMeyer，Picrasma quassioides Bennet，Rhus javanica L.，Betula platyphylla Sukatchev var.japonicum Hara，Coixlachryma-jobi L.var。 马en en f。。。。ii ii ii ii。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。 和百合百合，以及选自乳铁蛋白的一种或多种。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2003212752A
公开(公告)日：2003-07-30
申请号：JP2003037683
申请日：2003-02-17
Applicant: KAO CORP
Inventor： KITAHARA TAKASHI , NISHIMURA YOKO , NOJIRI HIROSHI , NITTA HIROYUKI , SATO NORIKO , HORI KIMIHIKO
IPC: A61K8/00 , A61K8/02 , A61K8/06 , A61K8/96 , A61K8/98 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K7/06 , A61K7/075 , A61K7/08
Abstract: PROBLEM TO BE SOLVED: To provide a cosmetic capable of sustainedly and topically inhibiting secretion of sebum in the skin and scalp, without adverse effects, highly safe and further having inhibitory actions on sebum synthesis. SOLUTION: This sebum secretion-inhibitory cosmetic comprises a lipid ingredient obtained by treating skin surface lipids collected from a mammal with a silica gel column chromatogram, eluting a hexane/benzene mixture liquid (1:1 volume ratio) and a hexane/diethyl ether mixture liquid (1:1 volume ratio) and then eluting the resultant fraction with acetone as an active ingredient. COPYRIGHT: (C)2003,JPO
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